Results 41 to 50 of about 596,662 (302)

Organization and segregation of bacterial chromosomes [PDF]

Nature Reviews Genetics, 2013
The bacterial chromosome must be compacted more than 1,000-fold to fit into the compartment in which it resides. How it is condensed, organized and ultimately segregated has been a puzzle for over half a century. Recent advances in live-cell imaging and genome-scale analyses have led to new insights into these problems. We argue that the key feature of
Xindan, Wang, Paula, Montero Llopis, David Z, Rudner   +2 more
openaire   +2 more sources

Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions [PDF]

, 2013
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation.
Philip W. Jordan (265255), Copsey A., Prakash Arumugam, Sonya Newcombe (502072), Jordan, Philip W., Gray S., Alice Copsey (4460686), Alex D Herbert, Eva Hoffmann (159398), Li, Zhaobo, Shangming Tang, Zhaobo Li, Stephen Gray, Newnham, Louise, Herbert A.D., Chan, Andrew Chi-ho, Hannah G. Blitzblau (159462), Blitzblau, Hannah G., Gray, Stephen, Alex Herbert (725932), Hannah G Blitzblau, Hannah Blitzblau (5185454), Newcombe S., Tang, Shangming, Stephen Gray (3278418), Newnham L., Li Z., Hunter, Neil, Andrew Chi-ho Chan (3278421), Hochwagen, Andreas, Arumugam, Prakash, Shangming Tang (502071), Hochwagen A., Alice Copsey, Alice Copsey (502070), Copsey, Alice, Herbert, Alex D., Hoffmann E., Blitzblau H.G., Andreas Hochwagen (159466), Arumugam P., Louise Newnham, Neil Hunter, Philip W Jordan (16188074), Jordan P.W., Alex D. Herbert (502074), Philip W Jordan, Andrew Chi-Ho Chan, Louise Newnham (430862), Sonya Newcombe, Chan, Andrew Chi ho, Tang S., Prakash Arumugam (303310), Eva Hoffmann, Newcombe, Sonya, Andreas Hochwagen, Hunter N., Chan A.C.-h., Neil Hunter (155061), Steve Gray (5950955), Zhaobo Li (502073), Hoffmann, Eva   +61 more
core   +1 more source

Chromosome segregation analysis in human embryos obtained from couples involving male carriers of reciprocal or Robertsonian translocation. [PDF]

PLoS ONE, 2012
The objective of this study was to investigate the frequency and type of chromosome segregation patterns in cleavage stage embryos obtained from male carriers of Robertsonian (ROB) and reciprocal (REC) translocations undergoing preimplantation genetic ...
Ahmet Yilmaz, Xiao Yun Zhang, Jin-Tae Chung, Seang Lin Tan, Hananel Holzer, Asangla Ao   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A simple biophysical model emulates budding yeast chromosome condensation

eLife, 2015
Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast ...
Tammy MK Cheng, Sebastian Heeger, Raphaël AG Chaleil, Nik Matthews, Aengus Stewart, Jon Wright, Carmay Lim, Paul A Bates, Frank Uhlmann   +8 more
doaj   +1 more source

Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted. [PDF]

, 2012
BACKGROUND: African trypanosomes belong to a eukaryotic lineage which displays many unusual genetic features. The mechanisms of chromosome segregation in these diploid protozoan parasites are poorly understood. Centromeres in Trypanosoma brucei have been
Bot, Christopher, Echeverry Maria C, Kelly John M, Obado Samson O, Echeverry, Maria C, Bot Christopher, Obado, Samson O, Kelly, John M, Taylor Martin C, Taylor, Martin C   +9 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Kif11-haploinsufficient oocytes reveal spatially differential requirements for chromosome biorientation

EMBO Reports
Bipolar spindle assembly and chromosome biorientation are prerequisites for chromosome segregation during cell division. The kinesin motor KIF11 (also widely known as Eg5) drives spindle bipolarization by sliding antiparallel microtubules bidirectionally,
Tappei Mishina, Aurélien Courtois, Shuhei Yoshida, Kohei Asai, Hiroshi Kiyonari, Tomoya S Kitajima   +5 more
doaj   +1 more source

Protocol for studying topological DNA interactions by purified fission yeast condensin

STAR Protocols
Summary: To understand the transition from interphase chromatin into well-shaped chromosomes during cell divisions, we need to understand the biochemical activities of the contributing proteins.
Minzhe Tang, Frank Uhlmann
doaj   +1 more source