Results 21 to 30 of about 596,662 (302)
On the regulation of chromosome segregation in human cells : implications of Bub1 Kinase inhibition during cell division [PDF]
, 2015 The maintenance of correct chromosome number (euploidy) during cell division is essential for health. Loss of euploidy is observed in most cancers and is linked to tumorigenesis.
Baron, Anna
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Structure of the cohesin loader Scc2
Nature Communications, 2017 The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces ...
William C. H. Chao +10 more
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A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit
Microbial Cell, 2018 The cell cycle is the process by which a cell duplicates its DNA during S-phase and divides its chromosomes during M-phase, creating two genetically identical daughter cells.
Sandra A. Touati, Frank Uhlmann
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Bacteria spring a surprise [PDF]
, 2014 Cell division involves the precise duplication of all the genetic material in the cell—both the chromosomes and the plasmid DNA—and the equal division of this material between the two daughter cells.
Srinivasan, Rajagopalan +3 more
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Exotic mitotic mechanisms [PDF]
, 2012 The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
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Contrasting roles of condensin I and condensin II in mitotic chromosome formation [PDF]
, 2012 © 2012. Published by The Company of Biologists LtdIn vertebrates, two condensin complexes exist, condensin I and condensin II, which have differing but unresolved roles in organizing mitotic chromosomes.
Choo, KH +13 more
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Bacterial chromosome segregation
Frontiers in Bioscience, 2012 Dividing cells have mechanisms to ensure that their genomes are faithfully segregated into daughter cells. In bacteria, the description of these mechanisms has been considerably improved in the recent years. This review focuses on the different aspects of bacterial chromosome segregation that can be understood thanks to the studies performed with model
Christophe, Possoz +2 more
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STAR Protocols, 2020 Summary: Amine-reactive Tandem Mass Tag 10plex (TMT10plex) labeling permits multiplexed protein identification and quantitative analysis by tandem mass spectrometry (MS/MS).
Andrew W. Jones +4 more
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Bacterial Chromosome Organization and Segregation [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Bacterial chromosomes are generally approximately 1000 times longer than the cells in which they reside, and concurrent replication, segregation, and transcription/translation of this crowded mass of DNA poses a challenging organizational problem. Recent advances in cell-imaging technology with subdiffraction resolution have revealed that the bacterial
Esteban, Toro, Lucy, Shapiro
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Deregulation of Chromosome Segregation and Cancer [PDF]
Annual Review of Cancer Biology, 2020 The mitotic spindle assembly checkpoint (SAC) is an intricate cell signaling system that ensures the high fidelity and timely segregation of chromosomes during cell division. Mistakes in this process can lead to the loss, gain, or rearrangement of the genetic material. Gross chromosomal aberrations are usually lethal but can cause birth and development
Curtis, Natalie L. +3 more
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