Results 81 to 90 of about 995,917 (290)
Nature Communications, 2017 Failure to restart replication forks stalled at genomic regions that are difficult to replicate or contain endogenous DNA lesions is a hallmark of BRCA2 deficiency.
Xianning Lai +7 more
semanticscholar +1 more source
Chromosome Segregation: Seeing Is Believing [PDF]
Current Biology, 2005 For chromosome segregation in mitosis, each centromere directs assembly of a complex, proteinaceous structure - the kinetochore, which connects the chromosome to microtubules of the mitotic spindle. A recent study has provided important new insights into the mechanism by which kinetochores capture spindle microtubules.
openaire +3 more sources
Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent
Cell Reports, 2016 Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for high-resolution fluorescence imaging (SeeDB2).
Meng-Tsen Ke +7 more
doaj +1 more source
Spindle asymmetry drives non-Mendelian chromosome segregation
Science, 2017 How selfish genes get their way At the core of Mendelian genetics is the concept that gametes are equally likely to carry either of the two parental copies of a gene.
Takashi Akera +8 more
semanticscholar +1 more source
The role of CSE1L expression in cervical lymph node metastasis of larynx tumors
Brazilian Journal of Otorhinolaryngology, 2021 Introduction: According to international reports, 30–40% of all head and neck cancers are larynx cancers, comprising 1–2.5% of all cancer types. Cervical nodal involvement has been reported to be 40% and 65% in T3 and T4 cases, respectively.
Tuncay Tunccan +7 more
doaj
Chromosome segregation occurs by microtubule pushing in oocytes
Nature Communications, 2017 During cell division, spindle microtubules ensure an equal repartition of chromosomes between the two daughter cells. While the kinetochore-dependent mechanisms that drive mitotic chromosome segregation are well understood, in oocytes of most species ...
K. Laband +6 more
semanticscholar +1 more source
Spindle mechanics and chromosome segregation
Molecular Biology of the Cell, 2019 The Minisymposium “Spindle Mechanics and Chromosome Segregation” featured new and exciting findings related to the spindle and chromosomes during mitosis and meiosis. It covered a range of topics including spindle architecture and mechanics, kinetochore–microtubule interactions, chromosome dynamics at mitotic entry and exit, as well as mitotic errors ...
Daniel W. Gerlich, Iva M. Tolić
openaire +4 more sources
Nature Communications, 2022 Tension stabilizes properly attached microtubules to kinetochores during chromosome segregation, and lack of tension leads to release. Here the authors show that tension directly suppresses Aurora B kinase mediated destabilization of reconstituted ...
Anna K. de Regt +3 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Chromosome segregation errors during female meiosis, the leading cause of birth defects and miscarriages, increase dramatically as women age.
Adrienne T. Perkins +3 more
semanticscholar +1 more source
eLife, 2022 Chromosome segregation requires both the separation of sister chromatids and the sustained condensation of chromatids during anaphase. In yeast cells, cohesin is not only required for sister chromatid cohesion but also plays a major role determining the ...
Jonay Garcia-Luis +4 more
doaj +1 more source