Results 51 to 60 of about 66,240 (247)

Bacterial programmed cell death and multicellular behavior in bacteria. [PDF]

PLoS Genetics, 2006
Traditionally, programmed cell death (PCD) is associated with eukaryotic multicellular organisms. However, recently, PCD systems have also been observed in bacteria.
Hanna Engelberg-Kulka, Shahar Amitai, Ilana Kolodkin-Gal, Ronen Hazan   +3 more
doaj   +1 more source

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

Advanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou, Xin‐Ge Wang, Xuan‐Ren Shi, Shu‐Ting Sun, Jing Mi, Xiao‐Peng Zhang, Bin‐Cheng Yin, Ying Zhou, Bang‐Ce Ye   +8 more
wiley   +1 more source

New views of the bacterial chromosome [PDF]

EMBO reports, 2004
The Keystone Symposium on Bacterial Chromosomes was held between 7 and 12 February 2004 in Santa Fe, New Mexico, USA. The conference was organized by S. Gottesman, N. Kleckner and J. Roth. ![][1] From the study of bacteria we know a great deal about DNA replication, recombination and repair, transcription, translation and gene regulation, and ...
Susan T. Lovett, Anca M. Segall
openaire   +2 more sources

Relative entropy differences in bacterial chromosomes, plasmids, phages and genomic islands

BMC Genomics, 2012
Background We sought to assess whether the concept of relative entropy (information capacity), could aid our understanding of the process of horizontal gene transfer in microbes.
Bohlin Jon, van Passel Mark WJ, Snipen Lars, Kristoffersen Anja B, Ussery David, Hardy Simon P   +5 more
doaj   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Model‐Guided Rational Construction of Escherichia coli Synthetic Consortia for Enhanced 2‐Methylbutyric Acid Production

Advanced Science, Volume 12, Issue 22, June 12, 2025.
We developed a citramalate‐derived pathway for 2‐methylbutyric acid production in E. coli mono‐culture and consortia. The optimized consortium, using 2‐keto‐3‐methylvalerate as a node, achieved 1817.03 ± 103.73 mg L−1 2‐methylbutyric acid, a 28‐fold increase from the initial strain, with a yield of 0.091 g/g glucose.
Yu Liu, Boyuan Xue, Shaojie Wang, Haijia Su   +3 more
wiley   +1 more source

Physical models of bacterial chromosomes

Molecular Microbiology
AbstractThe interplay between bacterial chromosome organization and functions such as transcription and replication can be studied in increasing detail using novel experimental techniques. Interpreting the resulting quantitative data, however, can be theoretically challenging.
Janni Harju, Chase P. Broedersz
openaire   +3 more sources

A Replisome’s journey through the bacterial chromosome [PDF]

Frontiers in Microbiology, 2015
Genome duplication requires the coordinated activity of a multi-component machine, the replisome. In contrast to the background of metabolic diversity across the bacterial domain, the composition and architecture of the bacterial replisome seem to have suffered few changes during evolution.
Thomas R. Beattie, Rodrigo Reyes-Lamothe
openaire   +4 more sources

Where and When Bacterial Chromosome Replication Starts: A Single Cell Perspective

Frontiers in Microbiology, 2018
Bacterial chromosomes have a single, unique replication origin (named oriC), from which DNA synthesis starts. This study describes methods of visualizing oriC regions and the chromosome replication in single living bacterial cells in real-time.
Damian Trojanowski, Joanna Hołówka, Jolanta Zakrzewska-Czerwińska   +2 more
doaj   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source