Results 1 to 10 of about 1,217,029 (160)

Ultra-purification of Lipopolysaccharides reveals species-specific signalling bias of TLR4: importance in macrophage function

Scientific Reports, 2021
TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products.
Matthew Stephens, Shan Liao, Pierre-Yves von der Weid   +2 more
doaj   +1 more source

5,2′-Dibromo-2,4′,5′-trihydroxydiphenylmethanone Inhibits LPS-Induced Vascular Inflammation by Targeting the Cav1 Protein

Molecules, 2022
Vascular inflammation is directly responsible for atherosclerosis. 5,2′-Dibromo-2,4′,5′-trihydroxydiphenylmethanone (TDD), a synthetic bromophenol derivative, exhibits anti-atherosclerosis and anti-inflammatory effects.
Hongxia Yuan, Qianyi Hou, Xiue Feng, Yuanlin Zhang, Fan Yang, Rui Ge, Qingshan Li   +6 more
doaj   +1 more source

GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49

Frontiers in Pharmacology, 2022
Renal fibrosis is an incurable disorder characterised by an imbalance of the extracellular matrix (ECM) favouring excess production over degradation.
Jinhong Ren, Jinhong Ren, Huizhi Wei, Jian Sun, Xiue Feng, Yuanlin Zhang, Hongxia Yuan, Junqiu Miao, Xiaoming Qi, Xiaoming Qi, Yuanbiao Qiao, Baoguo Xiao, Qingshan Li, Qingshan Li   +13 more
doaj   +1 more source

Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain

Heliyon, 2022
Ethnopharmacology relevance: Wuzi Yanzong Pill (WYP), a well-known prescription for invigorating the kidney and essence, which is widely used to treat infertility such as oligoasthenospermia.
Yan-Rong Li, Meng-Ying Sun, Wei Hang, Qi Xiao, Hui-Jie Fan, Lu Jia, Xiao-Ming Jin, Bo Zhang, Bao-Guo Xiao, Cun-Gen Ma, Zhi Chai   +10 more
doaj   +1 more source

Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Molecular Brain, 2020
Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors.
Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier   +9 more
doaj   +1 more source

Integrated analysis of intratumoral biomarker and tumor-associated macrophage to improve the prognosis prediction in cancer patients

BMC Cancer, 2023
Background The lack of effective and accurate predictive indicators remains a major bottleneck for the improvement of the prognosis of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Hepatitis B virus X (HBx) has been widely
Ming-Da Wang, Hao Xiang, Tian-Yu Hong, Abudurexiti Mierxiati, Fei-Hu Yan, Ling Zhang, Chao Wang   +6 more
doaj   +1 more source

Chronic gastrointestinal inflammation [PDF]

FEMS Immunology & Medical Microbiology, 1999
Chronic gastrointestinal inflammation is one of the most common types of inflammatory process which affects humans. It is diverse in aetiology, pathogenesis and manifestation. There are also features of chronic inflammation at different sites within the gastrointestinal tract which provide a common thread in terms of the approaches which may be used in
openaire   +2 more sources

A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

Allergy, Asthma & Clinical Immunology, 2018
Background Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to promote bronchoconstriction and ...
Tresa George, Mainak Chakraborty, Mark A. Giembycz, Robert Newton   +3 more
doaj   +1 more source

Evolutionary Approaches to Combat Antibiotic Resistance: Opportunities and Challenges for Precision Medicine

Frontiers in Immunology, 2020
The rise of antimicrobial resistance (AMR) in bacterial pathogens is acknowledged by the WHO as a major global health crisis. It is estimated that in 2050 annually up to 10 million people will die from infections with drug resistant pathogens if no ...
Matthias Merker, Matthias Merker, Matthias Merker, Leif Tueffers, Leif Tueffers, Marie Vallier, Marie Vallier, Espen E. Groth, Espen E. Groth, Espen E. Groth, Lindsay Sonnenkalb, Daniel Unterweger, Daniel Unterweger, John F. Baines, John F. Baines, Stefan Niemann, Stefan Niemann, Stefan Niemann, Hinrich Schulenburg, Hinrich Schulenburg   +19 more
doaj   +1 more source

Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

BMC Medical Genomics, 2019
Background Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma. However, reduced efficacy in severe disease or exacerbations indicates a
Mahmoud M. Mostafa, Christopher F. Rider, Suharsh Shah, Suzanne L. Traves, Paul M. K. Gordon, Anna Miller-Larsson, Richard Leigh, Robert Newton   +7 more
doaj   +1 more source