Updates in the chronic kidney disease-mineral bone disorder show the role of osteocytic proteins, a potential mechanism of the bone—Vascular paradox, a therapeutic target, and a biomarker [PDF]
Frontiers in Physiology, 2023 The chronic kidney disease-mineral bone disorder (CKD-MBD) is a complex multi-component syndrome occurring during kidney disease and its progression. Here, we update progress in the components of the syndrome, and synthesize recent investigations, which ...
Matthew J. Williams +4 more
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Chronic kidney disease mineral and bone disorder in children [PDF]
Pediatric Nephrology, 2007 Childhood and adolescence are crucial times for the development of a healthy skeletal and cardiovascular system. Disordered mineral and bone metabolism accompany chronic kidney disease (CKD) and present significant obstacles to optimal bone strength, final adult height, and cardiovascular health.
Bakkaloglu, SEVCAN AZİME +2 more
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Osteoprotegerin as an Early Sign of Chronic Kidney Disease-Mineral and Bone Disorder [PDF]
Acta Clinica Croatica, 2023 Chronic kidney disease (CKD) is among the most significant health problems, with the associated cardiovascular disease and bone metabolism disorders being the leading cause of morbidity and mortality in these patients.
Antun Gršković +6 more
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Sclerostin - a potential new marker of exercise influence on vascular calcification and mineral and bone disorder in hemodialysed adults [PDF]
Journal of Education, Health and Sport, 2019 Chronic Kidney Disease (CKD) is defined as abnormalities of kidney structure or function, present for >3 months, with implications for health. Amongst CKD complications the most fatal is cardiovascular disease, which together with Chronic Kidney ...
Agnieszka Turon-Skrzypinska +6 more
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Chronic Kidney Disease-Mineral and Bone Disorder. [PDF]
Biomed Res Int, 2017 Children with chronic kidney disease (CKD) are at high risk of developing mineral and bone disorders (MBD). CKD-MBD comprise altered calcium and phosphate homeostasis, abnormal synthesis and secretion of parathyroid hormone (PTH) and vitamin D and alterations in bone metabolism and function.
Lee WC, Ruan XZ, Chau YY, Chen JB.
europepmc +5 more sources
Relative comparison of chronic kidney disease-mineral and bone disorder rat models [PDF]
Frontiers in Physiology, 2023 Objective: The aim of this study is to establish a suitable animal model of chronic kidney disease–mineral and bone disorder (CKD–MBD) by comparing CKD–MBD rat models induced by 5/6 Nx, AN, and UUO, accompanied by a low-calcium and high-phosphorus diet ...
Xiaoqiong Zhang +10 more
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The role of transient receptor potential channels in chronic kidney disease-mineral and bone disorder [PDF]
Frontiers in PharmacologyChronic kidney disease (CKD) represents a major global health challenge, frequently resulting in the development of chronic kidney disease-mineral and bone disorder (CKD-MBD). Transient receptor potential (TRP) channels, particularly the TRPV (vanilloid),
Lerong Zhang +10 more
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Alkaline Phosphatases in the Complex Chronic Kidney Disease-Mineral and Bone Disorders [PDF]
Calcified Tissue International, 2018 Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple metabolic processes (from many molecules such as proteins, nucleotides, or pyrophosphate). Therefore, APs are important for bone mineralization but paradoxically they can also be deleterious for other processes, such as vascular calcification and the increasingly ...
Bover, Jordi +8 more
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Chronic Kidney Disease-Mineral and Bone Disorder in Asia. [PDF]
Kidney Dis (Basel), 2017 <b><i>Background:</i></b> Chronic kidney disease-mineral and bone disorder (CKD-MBD) is one of the most common complications in patients with CKD. As CKD-MBD is a systemic syndrome, prevention and management should be aimed at achieving better survival and less risk of cardiovascular events and fractures.
Fukagawa M, Komaba H.
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Correlation between soluble klotho and chronic kidney disease–mineral and bone disorder in chronic kidney disease: a meta-analysis [PDF]
Scientific ReportsWe conducted a systematic search across medical databases, including PubMed, Web of Science, EMBASE, and Cochrane Library, up to March 2023. A total of 1944 subjects or individuals from 17 studies were included in our final analysis.
Zhongyu Fan +6 more
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