Results 91 to 100 of about 16,068 (199)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Pathophysiology of chronic kidney disease-mineral bone disorder (CKD-MBD):from adaptive to maladaptive mineral homeostasis [PDF]

Chronic kidney disease-mineral bone disorder (CKD-MBD) is a multifaceted condition commonly seen in people with reduced kidney function. It involves a range of interconnected issues in mineral metabolism, bone health and cardiovascular calcification ...
Merkel, Nathalie, Salera, Davide, de Borst, Martin H; id_orcid, Bellasi, Antonio   +3 more
core   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Musculoskeletal health among adults with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To describe the burden of, and investigate prognostic factors for, osteoarthritis, osteopenia and/or osteoporosis, spondylosis, and fracture, and to investigate the effectiveness of protocols for monitoring musculoskeletal disorders and interventions for managing osteoarthritis in adults with cerebral palsy (CP).
Jennifer M. Ryan, Jessica Burke, Rachel Byrne, Emily Capellari, Christina M Marciniak, Maram Sofiany, Reuel Jalal, Mark Peterson, The Adult CP Clinical Practice Guideline Working Group, Jan Willem Gorter, Ashley Harris Whaley, Christine Imms   +11 more
wiley   +1 more source

Cardiovascular Risk Factors and Chronic Kidney Disease—FGF23: A Key Molecule in the Cardiovascular Disease

International Journal of Hypertension, 2014
Patients with chronic kidney disease (CKD) are at increased risk of mortality, mainly from cardiovascular disease. Moreover, abnormal mineral and bone metabolism, the so-called CKD-mineral and bone disorder (MBD), occurs from early stages of CKD.
Rika Jimbo, Tatsuo Shimosawa
doaj   +1 more source

Tirzepatide for Obesity in Adults ≥ 65 Years: A Post Hoc Analysis of the SURMOUNT and SUMMIT Clinical Trials

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Tirzepatide is a once‐weekly glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonist (RA) approved for weight management in adults with obesity. Data on older adults remain limited, however. This study aimed to examine tirzepatide's safety and efficacy in adults aged ≥ 65 years with obesity ...
Nasreen Alfaris, Robert F. Kushner, Jianghao Li, Kevin L. Chen, Mia Fenimore, Boris Calderon, Adam Stefanski   +6 more
wiley   +1 more source

Effect of mobile APP in the management and application of mineral and bone disorder in dialysis patients of chronic kidney disease

Linchuang shenzangbing zazhi
Objective To explore the adjustment and impact of chronic kidney disease-mineral and bone disorder (CKD-MBD) parameters in maintenance dialysis patients utilizing the Doctor-Patient Care App (Renal Care App).
Gulimire Muhetaer, Yue Qu, Xiao-wen Ha, Ling Zhang, Xiao-yu Wang, Yong-wu Yu, Hong Jiang   +6 more
doaj   +1 more source

Type 2 Diabetes Is Associated With Increased Complications and Mortality After Hip Fracture in Older Adults Aged 60 Years or Older

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Type 2 diabetes (T2D) is associated with increased hip fracture risk. We evaluated the impact of T2D on post‐hip fracture outcomes, which is less well described. Materials and Methods Individuals aged ≥ 60 years hospitalised for hip fractures between 2011 and 2020 were identified from the territory‐wide electronic health records of Hong ...
Xincheng Zou, Manju Chandran, Xi Xiong, Chi‐Ho Lee, Wing‐Sun Chow, Carol H. Y. Fong, Lawrence C. M. Lau, Ka‐Shing Cheung, Carlos K. H. Wong, Kathryn C. B. Tan, Yu‐Cho Woo, Karen S. L. Lam, David T. W. Lui   +12 more
wiley   +1 more source

Impact of chronic kidney disease mineral and bone disorder on jaw and alveolar bone metabolism: A narrative review

, 2018
© 2018 Quintessence Publishing Co., Ltd. Chronic kidney disease (CKD) has become a worldwide public health problem. It is estimated that nearly 90% of patients with chronic renal failure manifest some symptoms of oral disease.
Vasovic, Miroslav, Stolic, Radojica, Brajkovic D., Bijelic B., Kanjevac, Tatjana   +4 more
core   +1 more source

Clinical Efficacy of Vitamin D Supplements for the Treatment of Anemia in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Objective To conduct a meta‐analysis of clinical randomized controlled studies related to vitamin D supplements for the treatment of anemia in patients with chronic kidney disease (CKD), to evaluate the clinical efficacy of vitamin D supplements for CKD patients complicated with anemia.
Xiaodong Wanyan, Jiayun Xu
wiley   +1 more source