Results 71 to 80 of about 16,068 (199)
Linchuang shenzangbing zazhi, 2019 The kidney is not only an excretory organ, but also an important organ involved in the regulation of mineral metabolism. Due to the increasing incidence of chronic kidney disease, mineral and bone disorder secondary to chronic kidney disease(CKD-MBD ...
XU Gang, GUO Shui-ming, GE Shu-wang
doaj
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2020 Objective: the present study was aimed to evaluate the role of pharmaceutical services in improving the outcome of mineral bone disorder in patients with advanced chronic kidney disease.
Hawkar Qadir Baiz +2 more
doaj +1 more source
Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?
Clinical Pharmacology &Therapeutics, EarlyView.Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu +5 more
wiley +1 more source
The Evolving World of Chronic Kidney Disease Mineral Bone Disorder [PDF]
, 2013 Chronic kidney disease – mineral and bone disorder (CKD-MBD) is associated with a significant morbidity and mortality. In vitro and animal models suggest that phosphorous, calcium, parathyroid hormone, and vitamin D abnormalities, mediate the ...
Biagio Di Lorio +7 more
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Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Chronic kidney disease mineral bone disorder
, 2015 Chronic kidney disease – mineral bone disease (CKD-MBD) is a syndrome defined as a systemic mineral metabolic disorder associated with CKD. The term renal osteodystrophy, as a part of CKD-MBD, indicates a pathomorphological concept of bone lesions ...
DRAŠKO PAVLOVIĆ +9 more
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Future Postharvest and Food, EarlyView.A nutrient‐dense grain, proso millet is well‐known for its high protein content and vital amino acids. It is high in fiber, vitamins, and minerals and has many health advantages, including promoting heart health, enhancing digestion, and helping with weight management.
Sangeeta Yadav +3 more
wiley +1 more source
Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content
Food Safety and Health, EarlyView.By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao +8 more
wiley +1 more source
Journal of Periodontology, EarlyView.Abstract Background Free palatal gingival grafts (FGG) are commonly harvested during mucogingival procedures. The present study investigates age‐related local and systemic early secondary wound healing outcomes, following FGG harvest in a rat model. Methods A 4.2 mm diameter defect was created in the palate of 24 younger (2 m) and 24 older (6 m) Wistar
Maayan Atzmon‐Shavit +3 more
wiley +1 more source
Periodontitis during pregnancy: The effect on the gut microbiome and intestinal inflammation
Journal of Periodontology, EarlyView.Abstract Background Periodontitis has been epidemiologically associated with adverse pregnancy outcomes, but causality remains difficult to establish in humans due to confounding factors. This study uses a controlled murine model to examine the effects of experimentally induced periodontitis on the composition of the gut microbiota and gastrointestinal
Richard Bright +9 more
wiley +1 more source