Results 51 to 60 of about 16,068 (199)

Kidney Disease Progression Does Not Decrease Intestinal Phosphorus Absorption in a Rat Model of Chronic Kidney Disease–Mineral Bone Disorder

, 2019
The Cy/+ rat has been characterized as a progressive model of chronic kidney disease–mineral bone disorder (CKD‐MBD). We aimed to determine the effect of kidney disease progression on intestinal phosphorus absorption and whole‐body phosphorus balance in ...
Pamela J Lachcik, Kathleen M Hill Gallant, Srinivasan, Shruthi, Colby J Vorland, Gallant, Kathleen M. Hill, Lachcik, Pamela J., Shruthi Srinivasan, Sharon M Moe, Moe, Sharon M., Biruete, Annabel, Annabel Biruete, Vorland, Colby J., Neal X Chen, Chen, Neal X.   +13 more
core   +1 more source

Osteoporosis in chronic kidney disease [PDF]

, 2022
Objectives. The aim of this paper is to highlight the clinical manifestations of musculoskeletal disorders in chronic kidney disease. Material and methods.
Groza, Costina, Groza Costina
core   +1 more source

Musculoskeletal and Peripheral Nervous System Involvement in a Patient Undergoing Chronic Hemodialysis: A Case Report and Literature Review

Türk Osteoporoz Dergisi, 2021
Musculoskeletal system manifestations in chronic renal insufficiency are caused by complex bone metabolism alterations, which is now described under the umbrella term of chronic kidney disease mineral- and bone-related disorder instead of renal ...
Zeynep Tuba Bahtiyarca, Fatma Aytül Çakcı   +1 more
doaj   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Changes in bone mineral density in patients undergoing kidney transplantation

Indian Journal of Transplantation, 2021
Background and Aims: Bone health in chronic kidney disease (CKD) and its changes after kidney transplantation has been a subject of considerable interest.
Manjunath P Ramakrishna, Chankramath S Arun, Sandeep Sreedharan, Praveen V Pavithran, Nisha Bhavani, Renjitha Bhaskaran, Harish Kumar   +6 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review

Biology, 2023
Intense changes in mineral and bone metabolism are frequent in chronic kidney disease (CKD) and represent an important cause of morbidity and reduced quality of life. These disorders have conventionally been defined as renal osteodystrophy and classified
Lavinia Capossela, Serena Ferretti, Silvia D’Alonzo, Lorenzo Di Sarno, Valeria Pansini, Antonietta Curatola, Antonio Chiaretti, Antonio Gatto   +7 more
doaj   +1 more source

Long‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata   +10 more
wiley   +1 more source

Executive summary of the 2017 KDIGO Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guideline Update: what's changed and why it matters

, 2017
The KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of CKD-MBD represents a selective update of the prior CKD-MBD Guideline published in 2009.
Linda McCann, Herzog, Charles A., McCann, Linda, Markus Ketteler, Toussaint, Nigel D., Nigel D. Toussaint, Marc G. Vervloet, Sharon M. Moe, Fukagawa, Masafumi, Masafumi Fukagawa, Ketteler, Markus, Geoffrey A. Block, Charles A. Herzog, Moe, Sharon M., Block, Geoffrey A., Shroff, Rukshana, Vervloet, Marc G., Marcello A. Tonelli, Tonelli, Marcello A., Leonard, Mary B., Pieter Evenepoel, Evenepoel, Pieter, Rukshana Shroff, Mary B. Leonard   +23 more
core   +1 more source