Results 51 to 60 of about 16,013 (232)

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Alkaline Phosphatases in the Complex Chronic Kidney Disease-Mineral and Bone Disorders [PDF]

Calcified Tissue International, 2018
Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple metabolic processes (from many molecules such as proteins, nucleotides, or pyrophosphate). Therefore, APs are important for bone mineralization but paradoxically they can also be deleterious for other processes, such as vascular calcification and the increasingly ...
Bover, Jordi, Ureña, Pablo, Aguilar, Armando, Mazzaferro, Sandro, Benito, Silvia, López-Báez, Víctor, Ramos, Alejandra, daSilva, Iara, Cozzolino, Mario   +8 more
openaire   +3 more sources

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Musculoskeletal and Peripheral Nervous System Involvement in a Patient Undergoing Chronic Hemodialysis: A Case Report and Literature Review

Türk Osteoporoz Dergisi, 2021
Musculoskeletal system manifestations in chronic renal insufficiency are caused by complex bone metabolism alterations, which is now described under the umbrella term of chronic kidney disease mineral- and bone-related disorder instead of renal ...
Zeynep Tuba Bahtiyarca, Fatma Aytül Çakcı   +1 more
doaj   +1 more source

Changes in bone mineral density in patients undergoing kidney transplantation

Indian Journal of Transplantation, 2021
Background and Aims: Bone health in chronic kidney disease (CKD) and its changes after kidney transplantation has been a subject of considerable interest.
Manjunath P Ramakrishna, Chankramath S Arun, Sandeep Sreedharan, Praveen V Pavithran, Nisha Bhavani, Renjitha Bhaskaran, Harish Kumar   +6 more
doaj   +1 more source

The Evolving World of Chronic Kidney Disease Mineral Bone Disorder

EMJ Nephrology, 2013
Chronic kidney disease – mineral and bone disorder (CKD-MBD) is associated with a significant morbidity and mortality. In vitro and animal models suggest that phosphorous, calcium, parathyroid hormone, and vitamin D abnormalities, mediate the cardiovascular and bone diseases that characterise CKD-MBD and increase the risk of death.
A. Bellasi, A. Galassi, M. Cozzolino, B. Di Iorio   +3 more
openaire   +3 more sources

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

Advanced Science, EarlyView.
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Xu Chen, Xingyu Zhu, Zhixin Qiu, Yijia Zhu, Xinhui Zheng, Dongqi Fan, Jinglei Zhan, Congxiu Mao, Ping Ji, Tao Chen, Qingqing He   +10 more
wiley   +1 more source

Cardiovascular Risk and Mineral Bone Disorder in Patients with Chronic Kidney Disease

Kidney & Blood Pressure Research, 2013
The term chronic kidney disease-mineral bone disorder has been coined recently to highlight that the disturbed mineral and bone metabolism is a major contributor to vascular calcification and finally cardiovascular disease. This syndrome is characterized
Hagen Staude, Susann Jeske, Karin Schmitz, Gert Warncke, Dagmar-Christiane Fischer   +4 more
doaj   +1 more source

Closing the Loop: High‐Precision 3D Photofabrication in Living Tissues

Advanced Science, EarlyView.
Writing 3D microstructures inside living tissue demands more than laser access; It demands information. Hierarchical sensing captures thermal and mechanical states across pulse‐train, voxel, and structure timescales, feeding a controller that steers the laser in real time.
Amirbahador Zeynali, Mangirdas Malinauskas, Giuseppe Chirico   +2 more
wiley   +1 more source

A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder

International Journal of Endocrinology, 2017
Chronic kidney disease (CKD) is associated with mineral and bone disorder (MBD), which is the main cause of the extensively increased cardiovascular mortality in the CKD population.
Bianca Frauscher, Katharina Artinger, Alexander H. Kirsch, Ida Aringer, Foteini Moschovaki-Filippidou, Máté Kétszeri, Corinna Schabhüttl, Peter P. Rainer, Albrecht Schmidt, Tatjana Stojakovic, Astrid Fahrleitner-Pammer, Alexander R. Rosenkranz, Philipp Eller, Kathrin Eller   +13 more
doaj   +1 more source