Results 131 to 140 of about 16,068 (199)

Podocyte mPGES‐2 Determines Renal Aging and Contributes to Senile Osteoporosis

Aging Cell, Volume 25, Issue 7, July 2026.
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Dandan Zhong, Chang Hao, Mengyue Li, Jing Liu, Zheng Xu, Jianteng Zhou, Lu Zhao, Siyu Ni, Zhenchao Hu, Yue Sun, Yingying Zou, Dong Sun, Hao Guo, Zhanjun Jia, Dong Guo, Jun‐Li Cao, Ying Sun   +16 more
wiley   +1 more source

Mineral and bone disorder in chronic kidney disease

, 2010
Bubreg je ključni organ u regulaciji mineralnog metabolizma. U kroničnom bubrežnom zatajenju (KBZ) promjene u mineralnom metabolizmu javljaju se vrlo rano u samim počecima bolesti. Napredovanjem bubrežne bolesti promjene su sve izraženije. Poremećaji u
Orlić, Lidija, Lidija Orlić
core  

Real-world usage of Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD) biomarkers in nephrology practices

BACKGROUND: Chronic kidney disease mineral bone disorder (CKD-MBD) is a condition characterized by alterations of calcium, phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF-23) metabolism that in turn promote bone disorders ...
Re, Sartò GV, Cianciolo, G, La, Manna G, Fusaro, M, Cossettini, A, Nickolas, T, Cosmai, L, Ferrari, S, Barbuto, S, Gallieni, M   +9 more
core   +1 more source

The Influence of Dietary Interventions on Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). [PDF]

Nutrients, 2021
Rysz J, Franczyk B, Rokicki R, Gluba-Brzózka A.   +3 more
europepmc   +1 more source

Associations of Semaglutide With Skeletal Outcomes in People With Obesity, With and Without Type 2 Diabetes: A Target Trial Emulation

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5834-5847, July 2026.
ABSTRACT Aims To evaluate the associations between semaglutide initiation and long‐term skeletal outcomes in people with obesity, stratified by type 2 diabetes (T2D) status, using target trial emulation. Materials and Methods This retrospective cohort study used the TriNetX federated electronic health record network.
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Shao‐Chia Chen, Hao‐I Hsieh, Gideon Meyerowitz‐Katz, Yen‐Liang Liu, Pen‐Hua Su   +8 more
wiley   +1 more source

Bone and joint diseases in patients with chronic kidney disease

, 2012
Više od 50 godina poznato je kako je koštana bolest, bubrežna osteodistrofija, jedna od najčešćih komplikacija kronične bubrežne bolesti. Poremećaj mineralnoga metabolizma nastaje već u početnim stadijima bubrežnog zatajivanja.
Črne, Nataša, Pavlović, Draško
core  

New Insights to the Crosstalk between Vascular and Bone Tissue in Chronic Kidney Disease-Mineral and Bone Disorder. [PDF]

Metabolites, 2021
Mace ML, Egstrand S, Morevati M, Olgaard K, Lewin E.   +4 more
europepmc   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, Volume 293, Issue 13, Page 3848-3864, July 2026.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

A systematic evaluation of five different image-derived input functions for the clinical implementation of ¹⁸F-NaF bone PET/CT in patients with chronic kidney disease-mineral and bone disorder. [PDF]

Front Nucl Med, 2023
Theil J, Vrist MH, Bech JN, Fynbo CA.
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source