Results 61 to 70 of about 35,727 (251)

Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate). [PDF]

, 2019
Chronic kidney disease (CKD) is a major cause of morbidity and premature mortality and represents a significant global public health issue. Underlying this burden are the many complications of CKD, including mineral and bone disorders, anemia, and ...
Bino, Avi, Ganz, Tomas, Salusky, Isidro B   +2 more
core  

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Bone Disorders in Pediatric Chronic Kidney Disease: A Literature Review

Biology, 2023
Intense changes in mineral and bone metabolism are frequent in chronic kidney disease (CKD) and represent an important cause of morbidity and reduced quality of life. These disorders have conventionally been defined as renal osteodystrophy and classified
Lavinia Capossela, Serena Ferretti, Silvia D’Alonzo, Lorenzo Di Sarno, Valeria Pansini, Antonietta Curatola, Antonio Chiaretti, Antonio Gatto   +7 more
doaj   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

Changes in bone mineral density in patients undergoing kidney transplantation

Indian Journal of Transplantation, 2021
Background and Aims: Bone health in chronic kidney disease (CKD) and its changes after kidney transplantation has been a subject of considerable interest.
Manjunath P Ramakrishna, Chankramath S Arun, Sandeep Sreedharan, Praveen V Pavithran, Nisha Bhavani, Renjitha Bhaskaran, Harish Kumar   +6 more
doaj   +1 more source

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease [PDF]

, 2013
Background: Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community ...
Inoue, Tatsuyuki, Ito, Hiroshi, Kikumoto, Yoko, Kitagawa, Masashi, Kitamura, Shinji, Maeshima, Yohei, Makino, Hirofumi, Morinaga, Hiroshi, Nakamura, Kazufumi, Ogawa, Ayu, Sugiyama, Hitoshi, Takiue, Keiichi, Uchida, Haruhito Adam, Yamanari, Toshio   +13 more
core   +3 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cardiovascular Risk and Mineral Bone Disorder in Patients with Chronic Kidney Disease

Kidney & Blood Pressure Research, 2013
The term chronic kidney disease-mineral bone disorder has been coined recently to highlight that the disturbed mineral and bone metabolism is a major contributor to vascular calcification and finally cardiovascular disease. This syndrome is characterized
Hagen Staude, Susann Jeske, Karin Schmitz, Gert Warncke, Dagmar-Christiane Fischer   +4 more
doaj   +1 more source

Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative - a position paper [PDF]

, 2017
Renal osteodystrophy (ROD) is a heterogeneous group of metabolic bone diseases complicating progressive chronic kidney disease (CKD). Bone biomarkers and bone imaging techniques may help to assess bone health and predict fractures in CKD but do have ...
Bacchetta, J., Cannata-Andia, J., Cozzolino, M., D'Haese, P., Evenepoel, P., Ferreira, A., Haarhaus, M., Lafage Proust, M.H., Mazzaferro, S., Salam, S., Spasovski, G., Working Group on CKD-MBD, E.   +11 more
core   +3 more sources