Results 31 to 40 of about 468,644 (199)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Hyperphosphatemia of chronic kidney disease [PDF]

Kidney International, 2008
Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease.
Suresh Mathew, Ping Qiu, Keith A. Hruska, Raymond D. Pratt, Richard J. Lund   +4 more
openaire   +3 more sources

Fluctuations of estimated glomerular filtration rate outside kidney disease improving global outcomes diagnostic criteria for acute kidney injury in end-stage liver disease outpatients and outcome postliver transplantation [PDF]

, 2017
Background. Renal dysfunction in end-stage liver disease (ESLD) results fromsystemic conditions that affect both liver and kidney with activation of vasoconstrictor systems.
Berloco, Pasquale Bartolomeo, Cappoli, Andrea, Fiacco, Federica, GINANNI CORRADINI, Stefano, Melandro, Fabio, Merli, Manuela, Mitterhofer, Anna Paola, Nofroni, Italo, Poli, Edoardo, Rossi, Massimo, Tinti, Francesca, Umbro, Ilaria, Zavatto, Assunta   +12 more
core   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Treatment of chronic kidney disease [PDF]

Kidney International, 2012
Treatment of chronic kidney disease (CKD) can slow its progression to end-stage renal disease (ESRD). However, the therapies remain limited. Blood pressure control using angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) has the greatest weight of evidence.
Thomas H. Hostetter, Jeffrey M. Turner, Michal L. Melamed, Carolyn Bauer, Matthew K. Abramowitz   +4 more
openaire   +3 more sources

Adiponectin in Chronic Kidney Disease [PDF]

International Journal of Molecular Sciences, 2020
Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered as a marker of many negative ...
Jarosław Przybyciński, Violetta Dziedziejko, Kamila Puchałowicz, Leszek Domański, Andrzej Pawlik   +4 more
openaire   +3 more sources

Setting the stage for acute-on-chronic kidney injury [PDF]

, 2008
Acute-on-chronic kidney disease will be familiar to many nephrologists. Hsu et al. quantify the risk of acute-on-chronic disease across the stages of preexisting chronic kidney disease.
Coca, Coresh, Hewitt, Hsu, J.W. Dear, K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification, Mehta, P.S.T. Yuen, Schiffrin, Star, Waikar   +10 more
core   +1 more source

Long-term results of patients with type 2 diabetes attending a multidisciplinary diabetes kidney disease clinic [PDF]

, 2023
Background: Diabetic and chronic kidney disease together tend to worsen the outcomes. A newer approach to treat both the comorbid disease can slow down the prognosis of both the disease leading to quality of life. Aim: To evaluate the outcomes when the
Singh, Surendra Prasad
core   +2 more sources

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source