Results 91 to 100 of about 82,620 (274)
Haematologica, 2017 Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia ...
Ana M. Cosialls +12 more
doaj +1 more source
International Journal of Cancer, Volume 152, Issue 5, Page 879-912, 1 March 2023., 2023 Abstract Knowledge of the role in cancer etiology of environmental exposures as pesticides is a prerequisite for primary prevention. We review 63 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature.
Haleigh Cavalier +2 more
wiley +1 more source
Inferring clonal evolution of tumors from single nucleotide somatic mutations [PDF]
arXiv, 2012 High-throughput sequencing allows the detection and quantification of frequencies of somatic single nucleotide variants (SNV) in heterogeneous tumor cell populations. In some cases, the evolutionary history and population frequency of the subclonal lineages of tumor cells present in the sample can be reconstructed from these SNV frequency measurements.
arxiv
Haematologica, 2016 I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the pathogenesis of chronic lymphocytic leukemia, and a very feasible therapeutic target in this disease.
Nili Dezorella +5 more
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Haematologica, 2010 Background The aims of the present study were to ascertain the activation status of Akt in the primary cells of chronic lymphocytic leukemia and to investigate the effects of specific Akt inhibition on chronic lymphocytic leukemia-cell survival.Design ...
Jianguo Zhuang +7 more
doaj +1 more source
Cancer Detection via Determination of Fractal Cell Dimension [PDF]
arXiv, 1995 We utilize the fractal dimension of the perimeter surface of cell sections as a new observable to characterize cells of different types. We propose that it is possible to distinguish cancerous from healthy cells with the aid of this new approach. As a first application we show that it is possible to perform this distinction between patients with hairy ...
arxiv
Panels in Therapy. VI. The Management of Chronic Lymphocytic Leukemia [PDF]
, 1955 Frank H. Bethell +3 more
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TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah +2 more
wiley +1 more source
Haematologica, 2009 Background Programmed cell death has been traditionally related with caspase activation. However, it is now accepted that caspase-independent forms of programmed cell death also regulate cell death.
Sandrine Barbier +12 more
doaj +1 more source
Relation of Bone Marrow Findings to Serum Protein Changes in Lymphosarcoma, Chronic Lymphocytic Leukemia and Hodgkin’s Disease [PDF]
, 1960 Altan Onat, Talbert Cooper
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