Results 121 to 130 of about 281,573 (395)

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells

Haematologica, 2010
Background Bortezomib has been successfully used in the treatment of multiple myeloma and has been proposed as a potential treatment for chronic lymphocytic leukemia.
Maria Baou, Susan L. Kohlhaas, Michael Butterworth, Meike Vogler, David Dinsdale, Renata Walewska, Aneela Majid, Eric Eldering, Martin J.S. Dyer, Gerald M. Cohen   +9 more
doaj   +1 more source

Preleukemia: hematological disorders prior to onset of leukemia [PDF]

, 1975
Published data on Japanese leukemia patients with a preleukemic hematological disorder were assessed. The reexamined cases were from the "Japona Centra Revuo Medicina" reported during the period from 1952 to 1971.
Hiraki, Kiyoshi, Kitajima, Koichi, Mikochi, Hiroshi, Nakanishi, Toshio, Sakato, Junya, Takahashi, Isao   +5 more
core   +1 more source

Acalabrutinib monotherapy in patients with chronic lymphocytic leukemia who are intolerant to ibrutinib.

Blood Advances, 2019
The Bruton tyrosine kinase (BTK) inhibitor ibrutinib improves patient outcomes in chronic lymphocytic leukemia (CLL); however, some patients experience adverse events (AEs) leading to discontinuation.
F. Awan, A. Schuh, Jennifer R. Brown, R. Furman, J. Pagel, P. Hillmen, D. Stephens, J. Woyach, E. Bibikova, P. Charuworn, M. Frigault, A. Hamdy, R. Izumi, B. Linghu, P. Patel, M. Wang, J. Byrd   +16 more
semanticscholar   +1 more source

SnapShot: Chronic Lymphocytic Leukemia

Cancer Cell, 2017
Despite the recent advances in the therapeutic management of Chronic Lymphocytic Leukemia (CLL) patients, this common B cell malignancy still remains incurable. This SnapShot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental interactions, which contribute to disease progression and therapy resistance.
Elisa Ten Hacken, Romain Guieze, Catherine J. Wu, Catherine J. Wu   +3 more
openaire   +3 more sources

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

Blastoschizomyces capitatus pneumonia in a patient with untreated chronic lymphocytic leukemia

Medical Mycology Case Reports, 2018
Several cases have been reported of B. capitatus infections in immunocompromised patients. Acute leukemia is the main predisposing factor. Chronic lymphocytic leukemia (CLL) is not usually associated with opportunistic infections.
Laura Trovato, Maria Domina, Ada Vancheri, Salvatore Oliveri, Nicola Ciancio   +4 more
doaj   +1 more source

Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk [PDF]

, 2014
Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia ...
Allan, J M, Allsup, D J, Bailey, J R, Catovsky, D, Deaglio, S, Dearden, C, Di Bernardo, M C, Dyer, M J S, Fegan, C, Frydecka, I, Hall, A G, Harris, R J, Holroyd, A, Houlston, R S, Jackson, G H, Jamroziak, K, Jayne, S, Juliusson, Gunnar,, Karabon, L, Lund University., Mainou-Fowler, T, Majid, A, Mansouri, L, Marr, H, Pepper, C, Pettitt, A R, Pratt, G, Rosenquist, R, Sava, G P, Smedby, K E, Speedy, H E, Summerfield, G, Sunter, N J, Wang, Y, Woszczyk, D   +34 more
core   +4 more sources

Venetoclax resistance and acquired BCL2 mutations in chronic lymphocytic leukemia

Haematologica, 2019
Venetoclax is a first in class, highly specific antagonist of BCL2 and supersedes current standard treatments in haematologic malignancies as recently demonstrated in the MURANO trial.
E. Tausch, William L. Close, A. Dolnik, J. Bloehdorn, B. Chyla, L. Bullinger, H. Döhner, D. Mertens, S. Stilgenbauer   +8 more
semanticscholar   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma with antecedent chronic lymphocytic leukemia: a case report and review of the literature

Journal of Medical Case Reports, 2018
Background Chronic lymphocytic leukemia and chronic myeloid leukemia are the most common types of adult leukemia. However, it is rare for the same patient to suffer from both.
Khadega A. Abuelgasim, Hinna Rehan, Maha Alsubaie, Nasser Al Atwi, Mohammed Al Balwi, Saeed Alshieban, Areej Almughairi   +6 more
doaj   +1 more source