Results 161 to 170 of about 281,573 (395)

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

Advanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu, Hongchao He, Shilei Qiao, Yifan Shao, Lurong Wang, Zhengkui Zhang, Long Zhang, Fangfang Zhou   +7 more
wiley   +1 more source

Evidence for somatic selection of natural autoantibodies. [PDF]

, 1992
Natural autoantibodies are primarily immunoglobulin M (IgM) antibodies that bind to a variety of self-antigens, including self-IgG. Accounting for a large proportion of the early B cell repertoire, such polyspecific autoantibodies are speculated to ...
Carson, DA, Duffy, SF, Kipps, TJ, Martin, T   +3 more
core  

Globulin Coating of Neoplastic Lymphocytes in Chronic Lymphocytic Leukemia [PDF]

, 1963
Jerome I. Brody, Lawrence H. Beizer
openalex   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Studies on the Pseudouridinuria of Chronic Lymphocytic Leukemia [PDF]

, 1964
Marvin Lewis, Sherman M. Weissman, Myron Karon   +2 more
openalex   +1 more source

Molecular map of chronic lymphocytic leukemia and its impact on outcome

Nature Genetics, 2022
B. Knisbacher, Ziao Lin, C. Hahn, F. Nadeu, M. Duran-Ferrer, Kristen Stevenson, E. Tausch, J. Delgado, Alex Barbera-Mourelle, A. Taylor-Weiner, Pablo Bousquets-Muñoz, A. Díaz-Navarro, Andrew J. Dunford, Shankara K. Anand, H. Kretzmer, J. Gutiérrez-Abril, Sara López-Tamargo, S. Fernandes, Clare Sun, M. Sivina, L. Rassenti, C. Schneider, Shuqiang Li, L. Parida, A. Meissner, F. Aguet, J. Burger, A. Wiestner, T. Kipps, Jennifer R. Brown, M. Hallek, C. Stewart, D. Neuberg, J. Martín-Subero, X. Puente, S. Stilgenbauer, Catherine J. Wu, E. Campo, G. Getz   +38 more
semanticscholar   +1 more source

Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage

Advanced Science, EarlyView.
Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu, Fei Han, Yaodong Wang, Chenchen Yuan, Qingtian Zhu, Tianqi Xia, Lin Chen, Xiaowu Dong, Yanbing Ding, Weiming Xiao, Yuyan Zhang, Jiajia Pan, Hongwei Xu, Weiwei Chen, Bo Tu, Wei Li, Fei Wang, Weijuan Gong, Lianghao Hu   +18 more
wiley   +1 more source

Genomic aberrations and survival in chronic lymphocytic leukemia.

New England Journal of Medicine, 2000
H. Döhner, S. Stilgenbauer, A. Benner, E. Leupolt, A. Kröber, L. Bullinger, K. Döhner, Martin Bentz, P. Lichter   +8 more
semanticscholar   +1 more source

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, EarlyView.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

Advanced Science, EarlyView.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen, Ying Liang, Hongyan Wei, Mengxing Liu, Jin Wu, Wei Li, Wenxuan Li, Yuxiao Jin, Yinshan Li, Wei Zhao, Min Xiao, Kaicheng Zhou, Shuai Yang, Wenqiang Yu   +13 more
wiley   +1 more source