Results 141 to 150 of about 427,029 (392)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage [PDF]

, 2001
Emmanuelle Passegué, Wolfram Jochum, Marina Schorpp‐Kistner, Uta Möhle-Steinlein, Erwin F. Wagner   +4 more
openalex   +1 more source

P691: MODELLING OF IMMUNE RESPONSE IN CHRONIC MYELOID LEUKEMIA PATIENTS SUGGESTS POTENTIAL FOR TREATMENT REDUCTION PRIOR TO CESSATION

, 2022
Elena Karg, Christoph Baldow, Thomas Zerjatke, Richard E. Clark, Ingo Roeder, Artur C. Fassoni, Ingmar Glauche   +6 more
openalex   +1 more source

Evaluation of Hepatitis B Reactivation Among Patients With Chronic Myeloid Leukemia Treated With Tyrosine Kinase Inhibitors [PDF]

, 2020
Asmaa Atteya, Aiman Ahmad, Dima Daghstani, Kamran Mushtaq, Mohamed A. Yassin   +4 more
openalex   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Feasibility of iFISH patterns in hematologic malignancies among Congolese patients at Kinshasa University clinics

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To analyze the feasibility of detecting Ph1 in leukemia patients in the Kinshasa University Clinics in the Democratic Republic of Congo, at KU Leuven, Belgium.
Mireille Solange Nganga Nkanga, Benjamin Longo-Mbenza, Peter Vandenberghe, Fons Verdonck, Venant Tchokonte-Nana, Nkama Claude Nlandu, Roth Laure Mapapa Miakassissa, Paul Roger Beia Kazadi, Antoine Lufimbo Katawandja, Jacques Bikaula Ngwidiwo, Ntolo Jean-Pierre Mufuta, Kuanda Thomas Solo, Mbombo Aurore Cecilia Orphée Beia   +12 more
doaj   +1 more source

Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children's Oncology Group CML Working Group

Pediatric Blood & Cancer, 2019
Chronic myeloid leukemia (CML) accounts for 2‐3% of leukemias in children under 15 and 9% in adolescents aged 15‐19. The diagnosis and management of CML in children, adolescents, and young adults have several differences compared to that in adults.
U. Athale, N. Hijiya, B. Patterson, J. Bergsagel, Jeffrey R. Andolina, H. Bittencourt, K. Schultz, M. Burke, M. Redell, E. Kolb, D. Johnston   +10 more
semanticscholar   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

High Throughput FISH Analysis: A New, Sensitive Option For Evaluation of Hematological Malignancies

Turkish Journal of Hematology, 2013
OBJECTIVE: The aim of this study was to determine the efficiency of the high throughput FISH analysis (HTFA) method for detecting genetic alterations in hematological malignancies, which is a new bacterial artificial chromosome array-based approach ...
Hakan Savlı, Seda Eren, Nilüfer Üzülmez, Zeynep İlkay, Duygu Yavuz, Deniz Sünnetçi, Abdullah Hacıhanifioğlu, Naci Çine   +7 more
doaj   +1 more source