Results 31 to 40 of about 3,305,589 (380)

IL-21 Receptor Blockade Shifts the Follicular T Cell Balance and Reduces De Novo Donor-Specific Antibody Generation

Frontiers in Immunology, 2021
Donor-specific antibodies (DSAs) play a key role in chronic kidney allograft injury. Follicular T helper (Tfh) cells trigger the humoral alloimmune response and promote DSA generation, while T-follicular regulatory (Tfr) cells inhibit antibody production
Yeqi Nian, Yeqi Nian, Yeqi Nian, Yeqi Nian, Zhilei Xiong, Panpan Zhan, Panpan Zhan, Panpan Zhan, Zhen Wang, Yang Xu, Jianghao Wei, Jie Zhao, Jie Zhao, Jie Zhao, Jie Zhao, Yingxin Fu, Yingxin Fu, Yingxin Fu, Yingxin Fu   +18 more
doaj   +1 more source

Chronic rejection. [PDF]

Journal of the American Society of Nephrology, 1994
Current immunosuppressive protocols have significantly decreased graft loss to acute rejection but have had no effect on graft loss to chronic rejection. Recently, attention has been focused on the prevention and management of chronic rejection. Centers must come to a uniform definition of this phenomenon so that studies can be compared. It is believed
A J, Matas, J F, Burke, G A, DeVault, A, Monaco, J D, Pirsch   +4 more
openaire   +2 more sources

KIR and their HLA Class I ligands: Two more pieces towards completing the puzzle of chronic rejection and graft loss in kidney transplantation

PLoS ONE, 2017
Background Kidney transplantation is a life-saving treatment for patients with end-stage renal disease. However, despite progress in surgical techniques and patient management, immunological rejection continues to have a negative impact on graft function
Roberto Littera, Gianbenedetto Piredda, Davide Argiolas, Sara Lai, Elena Congeddu, Paola Ragatzu, Maurizio Melis, Elisabetta Carta, M.B. Michittu, Donatella Valentini, Luisella Cappai, R Porcella, F. Alba, Maria Serra, Valentina Loi, R Maddi, Sandro Orrù, Giorgio La Nasa, Giovanni Caocci, Roberto Cusano, Marcella Arras, Mauro Frongia, Antonello Pani, Carlo Carcassi   +23 more
openalex   +3 more sources

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Briggs, David, Dr., Daga, Sunil, Hamer, Rizwan, Higgins, Rob, Imray, C. (Chris), Kashi, Habib, Krishnan, Nithya S., Lam, F. T., Lowe, David Philip, Raymond, Neil T., Tan, Lam Chin, Zehnder, Daniel   +11 more
core   +5 more sources

Allograft or Recipient ST2 Deficiency Oppositely Affected Cardiac Allograft Vasculopathy via Differentially Altering Immune Cells Infiltration

Frontiers in Immunology, 2021
The role of IL-33/ST2 signaling in cardiac allograft vasculopathy (CAV) is not fully addressed. Here, we investigated the role of IL-33/ST2 signaling in allograft or recipient in CAV respectively using MHC-mismatch murine chronic cardiac allograft ...
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Zheng Tan, Feili Gong, Fang Zheng, Fang Zheng   +14 more
doaj   +1 more source

Single-Cell RNA Sequencing Reveals the Immunological Profiles of Renal Allograft Rejection in Mice

Frontiers in Immunology, 2021
Allograft rejection is a common immunological feature in renal transplantation and is associated with reduced graft survival. A mouse renal allograft rejection model was induced and single-cell RNA sequencing (scRNA-seq) data of CD45+ leukocytes in ...
Qixia Shen, Qixia Shen, Qixia Shen, Qixia Shen, Yucheng Wang, Yucheng Wang, Yucheng Wang, Jiaoyi Chen, Lifeng Ma, Xiaoru Huang, Xiaoru Huang, Sydney C. W. Tang, Huiyao Lan, Hong Jiang, Hong Jiang, Hong Jiang, Jianghua Chen, Jianghua Chen, Jianghua Chen   +18 more
doaj   +1 more source

Pathologic analysis of liver transplantation for primary biliary cirrhosis [PDF]

, 1988
A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other ...
Ballardini, Baum, Berg, Bernuau, Demetris, Demetris, Demetris, Demetris, Detre, Epstein, Epstein, Esquivel, Fennell, Fung, Haagsma, Iwatsuki, James, MacSween, McFarlane, McFarlane, Neuberger, Popper, Portmann, Portmann, Portmann, Vento   +25 more
core   +1 more source

Immune Checkpoints Expression in Chronic Lung Allograft Rejection

Frontiers in Immunology, 2021
Chronic lung allograft dysfunction (CLAD) is the main cause of poor survival and low quality of life of lung transplanted patients. Several studies have addressed the role of dendritic cells, macrophages, T cells, donor specific as well as anti-HLA ...
Ilaria Righi, Valentina Vaira, Valentina Vaira, Letizia Corinna Morlacchi, Giorgio Alberto Croci, Giorgio Alberto Croci, Valeria Rossetti, Francesco Blasi, Francesco Blasi, Stefano Ferrero, Stefano Ferrero, Mario Nosotti, Mario Nosotti, Lorenzo Rosso, Lorenzo Rosso, Mario Clerici, Mario Clerici   +16 more
doaj   +1 more source

Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection. [PDF]

, 2017
Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies
Butler, Carrie L, Reed, Elaine F, Thomas, Kimberly A, Valenzuela, Nicole M   +3 more
core   +4 more sources

Chronic allograft rejection: A significant hurdle to transplant success

Burns & Trauma, 2014
The state-of-the-art immunosuppression drugs do not ensure indefinite transplant survival, and most transplants are continuously lost to chronic rejection even years posttransplantation.
Malgorzata Kloc, Rafik M Ghobrial
doaj   +1 more source