Results 131 to 140 of about 5,912,442 (250)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

GIS express for chronic disease ; v. 3, issue 2, May 15, 2020

gis-express-vol3-issue2-508.pdfMaps in Action: COVID-19 Dashboard from Johns Hopkins University -- GIS Epi Resource: COVID-19 Data Hub from the US Census Bureau -- Atlas Insights: New and Updated Data Now Available -- Building GIS Capacity: Chronic ...

core  

Addressing chronic disease through community health workers : a policy and systems-level approach [PDF]

Second edition.This document provides guidance and resources for imple- menting recommendations to integrate community health workers (CHWs) into community-based e orts to prevent chronic disease. After providing general information on CHWs in the United

core  

Accurate genomic predictions for chronic wasting disease in North American elk. [PDF]

G3 (Bethesda)
Seabury CM, Bhattarai EK, Brun M, Johnson CD, Haley NJ, Mitchell GB, Nichols TA.   +6 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Chronic Wasting Disease in Free-Ranging Wisconsin White-Tailed Deer

Emerging Infectious Diseases, 2003
Damien O. Joly, Christine A. Ribic, Julie A. Langenberg, Kerry Beheler, Carl A. Batha, Brian J. Dhuey, Robert E. Rolley, Gerald Bartelt, Timothy R. van Deelen, Michael D. Samuel   +9 more
doaj   +1 more source

Correction: White-tailed deer population declines in a high-prevalence chronic wasting disease region of Arkansas, USA. [PDF]

PLoS One
Gaya HE, Jorge MH, Jorge LA, Ruder MG, D'Angelo GJ, Chandler RB, Chamberlain MJ.   +6 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Addressing chronic disease through community health workers; a policy and systems-level approach : a policy brief on community health workers [PDF]

This document provides guidance and resources for implementing recommendations to integrate community health workers (CHWs) into community-based efforts to prevent chronic disease. After providing general information on CHWs in the United States, it sets

core