Results 181 to 190 of about 59,618 (284)

Evaluation of spatial variation in chronic wasting disease risk with Bayesian Poisson log-Gaussian model. [PDF]

Front Vet Sci
Raghavan RK, Osei FB, Stein A, Hesting S, Jaster L, Hatuwal B, Mosley JE, Raghavan A.   +7 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Chronic wasting disease as a model for human prion therapy. [PDF]

Prion
Bordonaro M.
europepmc   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

The Strain Properties of Korean and North American Chronic Wasting Disease Prions Are Indistinguishable. [PDF]

J Infect Dis
Sohn HJ, DeFranco JP, Park HC, Park KJ, Bian J, Crowell J, Kim S, Webster BK, Kang HE, Telling GC.   +9 more
europepmc   +1 more source

Chronic Waste Disease schon seit Jahrzehnten bekannt: Kein Zusammenhang mit Stiftung

Viele Rehe und Hirsche in den USA sind mit einer Krankheit infiziert. Eine Übertragung auf den Menschen ist nicht ausgeschlossen.
Deutsche Presseagentur
core  

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Potential impact of parasites in the transmission of chronic wasting disease. [PDF]

Neural Regen Res
Soto P, Morales R.
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

PLGA nanoparticles for oral delivery of prion-specific antigen: a novel approach to chronic wasting disease vaccination. [PDF]

Sci Rep
Elsutohy MM, Abdelaziz D, Dalton CS, Kruger B, Phan S, Cheng YC, Low K, Ahmed-Hassan H, Schätzl HM.   +8 more
europepmc   +1 more source