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CHRONIC WASTING DISEASE MODELING: AN OVERVIEW

Journal of Wildlife Diseases, 2020
Chronic wasting disease (CWD) is an infectious and fatal prion disease occurring in the family Cervidae. To update the research community regarding the status quo of CWD epidemic models, we conducted a meta-analysis on CWD research. We collected data from peer-reviewed articles published since 1980, when CWD was first diagnosed, until December 2018. We
Steven N, Winter, Luis E, Escobar
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Chronic Wasting Disease of Cervids

2004
Chronic wasting disease (CWD) has recently emerged in North America as an important prion disease of captive and free-ranging cervids (species in the deer family). CWD is the only recognized transmissible spongiform encephalopathy (TSE) affecting free-ranging species.
M W, Miller, E S, Williams
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Muscle wasting in chronic kidney disease

Pediatric Nephrology, 2017
Loss of lean body mass is a relevant component of the cachexia, or protein energy wasting (PEW), syndrome. Reduced muscle mass seems to be the most solid criterion for the presence of cachexia/PEW in patients with chronic kidney disease (CKD), and those with greater muscle mass loss have a higher risk of death.
Eduardo A. Oliveira   +3 more
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Scrapie and chronic wasting disease

Clinics in Laboratory Medicine, 2003
Scrapie and CWD share many features. There are marked similarities in the clinical presentations, the lesions, and the pathogenesis of these diseases, and some similarities in the epidemiology. Extrapolation from the scrapie model of TSE disease to CWD--which occurs in three different species, and should not be considered to be uniform in their ...
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Chronic Wasting Disease

2014
Chronic Wasting Disease is a transmissible spongiform ecephalopathy (TSE) or Prion disease which causes neurological disease found in deer and elk that produces small lesions in the brains of infected animals. Since this disease has yet to infect humans, it is an ideal model to use in the laboratory for safety reasons.
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ADRENAL FUNCTION IN CHRONIC WASTING DISEASES

The Journal of Clinical Endocrinology & Metabolism, 1960
ABSTRACT Plasma and urinary 17-hydroxycorticosteroids (17-OH-CS) were measured in a group of 29 patients in whom body wasting was, with few exceptions, due to chronic disease. The total urinary 17-OH-CS output was low due to a reduction in the glucuronide conjugated fraction,but plasma free 17-OH-CS concentration and urinary free 17-OH-CS output were ...
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Oxidative stress, chronic disease, and muscle wasting

Muscle & Nerve, 2007
AbstractUnderlying the pathogenesis of chronic disease is the state of oxidative stress. Oxidative stress is an imbalance in oxidant and antioxidant levels. If an overproduction of oxidants overwhelms the antioxidant defenses, oxidative damage of cells, tissues, and organs ensues.
Jennifer S, Moylan, Michael B, Reid
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Chronic wasting disease of cervids

Small Ruminant Research, 2015
Abstract Chronic wasting disease (CWD) of cervids is the only known transmissible spongiform encephalopathy (TSE) found in non-domestic, free-ranging animals. To date, it is found in wild cervids only in North America, and natural infection has been detected in only four species (Cervus elaphus nelsoni, Odocoileus hemionus, Odocoileus virginianus and
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Chronic wasting disease: an evolving prion disease of cervids

2018
Chronic wasting disease (CWD) is a relatively new and burgeoning prion epidemic of deer, elk, reindeer, and moose, which are members of the cervid family. While the disease was first described in captive deer, its subsequent discovery in various species of free-ranging animals makes it the only currently recognized prion disorder of both wild and ...
Sylvie L, Benestad, Glenn C, Telling
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