Results 51 to 60 of about 3,030 (150)

Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex

Cancer Cell International
Background Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and lymph nodes and is linked with poor prognosis and poor survival. Methods Here, we used in vitro and in silico methods to
Mücahit Varlı, Eunae Kim, Songjin Oh, Sultan Pulat, Rui Zhou, Chathurika D. B. Gamage, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man-Jeong Paik, Hangun Kim   +10 more
doaj   +1 more source

Root Endophytic Fungi Regulate Changes in Sugar and Medicinal Compositions of Polygonum cuspidatum

Frontiers in Plant Science, 2022
Polygonum cuspidatum Sieb. et Zucc is an important industrial crop because it contains a large amount of medicinal secondary metabolites (such as polydatin, resveratrol, chrysophanol, and emodin).
Rui-Ting Sun, Xiang-Cao Feng, Ze-Zhi Zhang, Nong Zhou, Hai-Dong Feng, Yi-Mei Liu, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Elsayed Fathi Abd_Allah, Qiang-Sheng Wu   +9 more
doaj   +1 more source

Peer review of the pesticide risk assessment of the active substance Trichoderma harzianum T78

EFSA Journal, Volume 24, Issue 7, July 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State, The Netherlands, for the pesticide active substance Trichoderma harzianum T78 and the considerations as regards the inclusion of the substance in Annex IV ...
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Silvia Mazzega, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Adriana Scattareggia Marchese, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +48 more
wiley   +1 more source

Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation. [PDF]

PLoS ONE, 2013
Aloe vera (Asphodeloideae) is a medicinal plant in which useful secondary metabolites are plentiful. Among the representative secondary metabolites of Aloe vera are the anthraquinones including aloe emodin and chrysophanol, which are tricyclic aromatic ...
Yun Sun Lee, Hyun Kyoung Ju, Yeon Jeong Kim, Tae-Gyu Lim, Md Romij Uddin, Yeon Bok Kim, Jin Hong Baek, Sung Won Kwon, Ki Won Lee, Hak Soo Seo, Sang Un Park, Tae-Jin Yang   +11 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, Volume 7, Issue 2, Page 52-66, June 2026.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Study on Dyeing Properties of Chrysophanol on Poly(trimethylene terephthalate)Fiber

, 2011
In order to provide the theoretical basis for synthetic fiber dyeing with natural dyes, the dyeing properties of chrysophanol on Poly(trimethylene terephthalate)(PTT) fiber were investigated.
Cai Yun Shi, Jia Wei Wang, Xiang Rong Wang, Yun Zhang   +3 more
core   +1 more source

Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Polyphenols, a group of complex naturally occurring compounds, are widely distributed throughout the plant kingdom and are therefore readily consumed by humans.
Zenghui Teng, Chengjun Yuan, Feng Zhang, Menglei Huan, Weidong Cao, Kangchu Li, Jingyue Yang, Dayong Cao, Siyuan Zhou, Qibing Mei   +9 more
doaj   +1 more source

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

MedComm, Volume 7, Issue 6, June 2026.
Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu, Lin Jia, Kerong Wu, Mo Chen, Jichao Sun, Chuanbin Yang, Chengchao Xu, Jie Sun, Jigang Wang, Lingyun Dai   +9 more
wiley   +1 more source

Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells

, 2016
Anthraquinone compounds have been shown to induce apoptosis in different cancer cell types. Effects of chrysophanol, an anthraquinone compound, on cancer cell death have not been well studied.
Lee, Tsung-Han, Wood, Wellington G, Hsia, Te-Chun, Yang, Jai-Sing, Huang, An-Cheng, Kuo, Chao-Lin, Chou, Su-Tze, Lu, Hsu-Feng, Lu, Chi-Cheng, Chung, Jing-Gung   +9 more
core   +2 more sources

In-Silico UHPLC Method Optimization for Aglycones in the Herbal Laxatives Aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots

Molecules, 2017
For the European Pharmacopoeia (Ph. Eur.) herbal monograph draft of Cassia angustifolia Vahl. and Cassia senna L. leaves and pods, a safety limitation of aloe-emodin and rhein was proposed, due to toxicological concerns. A quantitative, analytical method
Nadja Meier, Beat Meier, Samuel Peter, Evelyn Wolfram   +3 more
doaj   +1 more source