Results 61 to 70 of about 4,551 (194)

Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro

Biomedicine & Pharmacotherapy, 2019
To better understand the hepatotoxicity of anthraquinone glycosides, the hepatotoxicity of six anthraquinone glycosides was evaluated. The results show that chrysophanol-8-O-glucoside(C8G) has strong hepatotoxicity and can lead to increased LDH leakage and ROS, decreased GSH and MMP in L-02 hepatocytes.
Longfei, Lin, Fang, Yuan, Yuling, Liu, Ming, Zhong, Tanggui, Xie, Jian, Ni, Hui, Li   +6 more
openaire   +2 more sources

Genome‐wide analysis of the AP2/ERF gene family in Rheum officinale Baill.: Evolution and expression profiling during plant development, abiotic stresses, and exogenous hormone responses

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract The APETALA2/ethylene‐responsive factor (AP2/ERF) superfamily plays a central role in plant metabolism, stress responses, and hormone signaling. Rheum officinale Baill. is an important traditional medicinal plant whose roots and rhizomes are rich in anthraquinones and other secondary metabolites.
Jing Tang, Gao‐chang Cui, Heng Pan, Hui Lu, Yi‐min Li, Feng Yan, Jing Gao, Liang Peng, Xiao‐chen Hu, Gang Zhang   +9 more
wiley   +1 more source

Inhibitory Effects of Litchi Extract on Sebum Secretion and Its Mechanism: Evidence From a Mouse Model and Sebaceous Gland Cell Transcriptomics

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Objective Acne vulgaris is one of the most common chronic inflammatory dermatological disorders, affecting 85%–100% of adolescents and persisting into adulthood for a significant portion of the population. Litchi chinensis, a subtropical fruit originating from Southern China and famously associated with the Guangzhou region, is commercially ...
Qinqian Tao, Xingmei Chen, Xian Chen, Xiang Yang, Erping Yan   +4 more
wiley   +1 more source

In-Silico UHPLC Method Optimization for Aglycones in the Herbal Laxatives Aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots

Molecules, 2017
For the European Pharmacopoeia (Ph. Eur.) herbal monograph draft of Cassia angustifolia Vahl. and Cassia senna L. leaves and pods, a safety limitation of aloe-emodin and rhein was proposed, due to toxicological concerns. A quantitative, analytical method
Nadja Meier, Beat Meier, Samuel Peter, Evelyn Wolfram   +3 more
doaj   +1 more source

Determination of Dried Root Extract of Rheum emodi and its Commercial Products Using Rhein and Chrysophanol as Standard Markers by HPTLC Densitometric Analysis

Pharmacognosy Research
Background: Standardization and quality control of medicinal plants and their commercial products are one of the critical needs for ensuring their quality, safety and efficacy which assists in validation as well as regulation of herbal medicines and ...
Rizwan Ahmad, Z. Fatima, Sadath Ali, S. Dhaneshwar, S. Ahmad   +4 more
semanticscholar   +1 more source

Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers

Molecules
Emodin, a trihydroxy-methyl anthraquinone abundant in rhubarb, Polygonum species, and other medicinal plants, exemplifies the therapeutic potential and translational complexity of the broader anthraquinone scaffold.
Rositsa Mihaylova, Viktoria Elincheva, Rumyana Simeonova, Georgi Momekov   +3 more
doaj   +1 more source

Constituintes químicos do caule de Senna reticulata Willd. (Leguminoseae): Chemical constituents isolated from the wood of Senna reticulata Willd.

Química Nova, 2008
The phytochemical investigation of the wood extracts of Senna reticulata (Leguminoseae) yielded six anthraquinones: chrysophanol, physcion, aloe-emodin, 1,3,8-trihydroxyanthraquinone, 3-methoxy-1,6,8-trihydroxyanthraquinone, emodin and the chrysophanol ...
Rogério Nunes dos Santos, Maria Goretti de Vasconcelos Silva, Raimundo Braz Filho   +2 more
doaj   +1 more source

In Vitro Antitrypanosomal and Antibacterial Activity of Aqueous, Hydroethanolic and Ethanolic Extracts of Rumex obtusifolius L. Leaf and Root

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
ABSTRACT Plant extracts are an important raw material for the development of new drugs. Rumex obtusifolius L., popularly known as ‘bitter dock’, has significant pharmacological properties. This study evaluated the in vitro antitrypanosomal activity of aqueous, hydroethanolic and ethanolic extracts from the leaf and roots of R. obtusifolius L.
Gabriela K. Borges, Gabriella B. Das Neves, Letícia Reichardt, Ubirajara Maciel da Costa, Luiz C. Miletti, Amanda L. Bastos‐Pereira   +5 more
wiley   +1 more source

Antithrombin Effect of Jidabokuippo and Identification of Active Compounds

Natural Product Communications, 2022
Static blood (Oketsu) is a blood disorder of Kampo medicine. Many natural medicines have been used to cure static blood, and these drugs are called blood stasis-resolving formula. Some of these were reported to inhibit blood coagulation.
Yuka Koike, Satoshi Takamatsu, Shin-ichiro Kurimoto, Kazuyoshi Kawazoe   +3 more
doaj   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, Volume 4, Issue 1, March 2026.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source