Results 41 to 50 of about 57,869 (249)

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Oxyanion and tetrahedral intermediate stabilization by subtilisin : detection of a new tetrahedral adduct

, 2009
The peptide-derived glyoxal inhibitor Z-Ala-Ala-Phe-glyoxal has been shown to be ~10 fold more effective as an inhibitor of subtilisin than Z-Ala-Pro-Phe-glyoxal. Signals at 107.2 p.p.m. and 200.5 p.p.m.
Rogers, Louis, Howe, Nicole, Hewage, Chandralal, Malthouse, J.Paul G.   +3 more
core   +1 more source

I. Stereospecificity in alpha-Chymotrypsin-Catalyzed Reactions. II. The Structural Specificity of alpha-Chymotrypsin: Some New Substrates. III. A Further Study of Monofunctional Aromatic Inhibitors of alpha-Chymotrypsin [PDF]

, 1964
A series of acylated glycine, D and L-alanine methyl esters have been evaluated as substrates for alpha-chymotrypsin. These results are correlated with a theory concerning the stereospecificity of the enzyme.
Rapp, James Ray
core   +1 more source

Protein Surface Recognition by Synthetic Receptors:  A Route to Novel Submicromolar Inhibitors for α-Chymotrypsin

, 2016
A family of synthetic receptors for protein surface recognition has been prepared. The receptors are based on a design in which four peptide loops are arrayed around a central calilx[4]arene core.
Hyung Soon Park (1849453), Qing Lin (5273), Andrew D. Hamilton (1931983)   +2 more
core   +1 more source

Investigation of a Serine Protease Inhibitor Active in the Infectious Stage of the Human Liver Fluke Opisthorchis viverrini

Pathogens
Serine protease inhibitors (serpins) participate in the regulation of inflammation, blood coagulation, and complement activation in humans. This research aimed to identify and characterize such inhibitors of the human liver fluke Opisthorchis viverrini ...
Rosnanee Salang, Wansika Phadungsil, Amornrat Geadkaew-Krenc, Rudi Grams   +3 more
doaj   +1 more source

N-[2,2-Dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-l-phenylalanine Ethyl Ester as a Stable Ester-Type Inhibitor of Chymotrypsin-like Serine Proteases:  Structural Requirements for Potent Inhibition of α-Chymotrypsin

, 2016
We introduce a new potent inhibitor, N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-l-phenylalanine ethyl ester (3), which preferentially inhibits serine proteases belonging to a chymotrypsin superfamily.
Isao Uno (3021969), Emiko Yasuda (3021972), Kiyoko Iijima (3021966), Yoshio Hayashi (111974), Jun Katada (3021975)   +4 more
core   +1 more source

Determining the Nutritional Potential of Ancient Wheat Species: A Closer Look at Starch and Protein Digestibility, and Phenolic Acid Content

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives The recent trend towards healthy food choices and sustainable agriculture has revived interest in underutilized wheat species such as emmer, einkorn, and spelt. Given these developments, the objective of the study was to compare the differences in chemical composition and digestibility characteristics among ...
Sathsara Deyalage, Sijo Joseph Thandapilly, James Duncan House, Adam Franczyk, Amanda Gomes Almeida Sá, Maneka Malalgoda   +5 more
wiley   +1 more source

α-Chymotrypsin-catalyzed synthesis of 2-substituted benzimidazole through retro-Claisen reaction

, 2018
Benzimidazoles are important components of pharmaceutical compounds owing to their promising bioactivities. The green, safe, and efficient synthesis of benzimidazoles has always been one of the hot topics for chemical workers.
Lei-Han Fu, Zong-Bo Xie (831279), Lei-Han Fu (5926514), Zong-Bo Xie, Zhang-Gao Le (831282), Can Zhang, Hai-Bo Zhu, Lian-Sheng Liu (5926511), Lian-Sheng Liu, Can Zhang (56016), Hai-Bo Zhu (5926517), Zhang-Gao Le   +11 more
core   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source