Results 41 to 50 of about 2,450,551 (302)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

El porqué del desarrollo insuficiente de la filosofía de las ciencias sociales

open access: yes, 2018
Se persigue demostrar que las ciencias sociales no han tenido el desarrollo suficiente porque Comte legitimo solo la metodologia de las ciencias naturales, como la unica valida para elaborar las ciencias sociales.
J. C. Escudero
semanticscholar   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Métodos estadísticos utilizados en las ciencias del movimiento humano

open access: yesRevista Educación, 2004
El propósito de este estudio fue describir los métodos estadísticos más utilizados en una revista del área de las ciencias del movimiento humano indexada en el Science Citation Index, la cual obtuvo en el año 1999 un factor de impacto 2.110.
José Moncada Jiménez
doaj  

Inclusion Strategies in University Sciences Education: Current Bioethical Challenges

open access: yesRevista Iberoamericana de Bioética, 2019
The last decades have witnessed a search for true inclusion in education, especially considering that inclusive education refers to an education based on the needs of each individual.
Marcos Fernando Ocaña Sánchez   +7 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

A Formação de professores e os desafios de ensinar Ciências

open access: yes, 2017
Este artigo tem como objetivo refletir a respeito da formacao inicial e/ou continuada dos professores, de seus desafios no ensino de Ciencias e da forma como orientam seus alunos na construcao do conhecimento cientifico. Aborda, sob a otica de diferentes
Rita Helena Moreira Seixas   +2 more
semanticscholar   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

La Facultad de Ciencias de la Educación [PDF]

open access: yes, 2009
Por decreto del Superior Gobierno de la Nación de fecha Mayo 30 de 1914, se ha creado en la Universidad Nacional de La Plata, la «Facultad de Ciencias de la Educación», constituida por las secciones de Pedagogía y de Filosofía, Historia y Letras, que ...
Departamento de Ciencias de la Educación
core  

Escribir ciencia: un desafío que comienza en la escuela primaria

open access: yesRevista Eureka sobre Enseñanza y Divulgación de las Ciencias, 2016
Este estudio considera que el docente de ciencias debería ser mediador en la adquisición de habilidades de lectura y escritura en el área de Ciencias Naturales.
Carina Rudolph   +3 more
doaj  

Home - About - Disclaimer - Privacy