Results 211 to 220 of about 2,723 (238)
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Recovery of ciguatoxin from fish flesh
Toxicon, 1993A mouse bioassay, validated for the quantification of ciguatoxin in up to 20 mg of ether extract from fish flesh, revealed that 63 +/- 14% of spiked ciguatoxin was recovered using a standard extraction procedure. Except for extracts from the least toxic of ciguateric fish (0.1-0.5 nmol ciguatoxin-1/kg fish), signs in mice of intoxication by ciguatoxin (
Lewis, RJ, Sellin, M
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Analytical challenges to ciguatoxins
Current Opinion in Food Science, 2017Ciguatera fish poisoning (CFP) is a form of food poisoning caused by consumption of varieties of toxic ciguatera fish species from tropical and subtropical waters. In the present review, significant features and perspective of LC/MS methods for CTXs as confirmatory methods are reviewed on the discussion for one of the best LC/MS/MS method reported by ...
Toshiyuki Suzuki +3 more
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Total Synthesis of Ciguatoxin and 51-HydroxyCTX3C
Journal of the American Chemical Society, 2006Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are large ladder-like polycyclic ethers with the 13 ether rings ranging from five- to nine-membered. In this paper, we describe the total synthesis of the two most toxic members of the ciguatoxin family, ciguatoxin 1 and 51-hydroxyCTX3C 2, based on a unified synthetic strategy.
Masayuki, Inoue +9 more
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A radioimmunoassay for the detection of ciguatoxin
Toxicon, 1977Abstract A practical, sensitive, simple and relatively specific radioimmunoassay test for the assay of ciguatoxin directly from natural sources has been developed. The radioimmunoassay test has been utilized to distinguish the toxic fishes in human ciguatera poisoning outbreaks from the nontoxic fishes.
Y, Hokama, A H, Banner, D B, Boylan
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Ciguatoxin: developing the methodology for total synthesis
Natural Product Reports, 2010Covering: up to 2009 The ciguatoxins are sodium channel toxins from the marine dinoflagellate Gambierdiscus toxicus, isolated in 1984. In this review, we summarize the principal concepts and recently developed methodologies for the synthesis of the ciguatoxins, including C–C bond formation by silylacetylene and cobalt-mediated cyclization.
Minoru, Isobe, Akinari, Hamajima
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An investigation into ciguatoxin bioaccumulation in sharks
Toxicon, 2016Ciguatoxins (CTXs) produced by benthic Gambierdiscus dinoflagellates, readily biotransform and bioaccumulate in food chains ultimately bioconcentrating in high-order, carnivorous marine species. Certain shark species, often feeding at, or near the top of the food-chain have the ability to bioaccumulate a suite of toxins, from both anthropogenic and ...
Lauren Meyer +3 more
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Multiple ciguatoxins in the flesh of fish
Toxicon, 1992Most cases of ciguatera (fish poisoning) result from consumption of the flesh of fishes contaminated with ciguatoxin(s); however, the relatively low toxicity of ciguateric fish flesh has hindered attempts to identify these ciguatoxin(s). Utilising high performance liquid chromatography, mass spectroscopy and mouse bioassay signs we have determined that
Lewis, Richard J., Sellin, Michelle
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Isolation and characterisation of Indian Ocean ciguatoxin
Toxicon, 2002We report the isolation and initial characterisation of Indian Ocean ciguatoxin (I-CTX) present in toxic lipid soluble extracts isolated from ciguateric fishes collected off the Republic of Mauritius in the Indian Ocean. Following i.p. injection of this extract, mice displayed symptoms that were similar, though not identical, to those produced by ...
Hamilton, B. +4 more
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[Ciguatoxin and edible reef fishes].
Bulletin de la Societe de pathologie exotique et de ses filiales, 1976Referring to the various human and animal clinical response to consumption of reef fish, the authors precise the importance of ingested dose and the role of cumulative effects. They point out the arbitrary character of distinguishing poisonous and edible fish of the same species. At the light of these data they find ciguatoxin in edible fish from known
R, Bagnis, J P, Vernoux
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