CD44v6 as innovative sarcoma target for CAR-redirected CIK cells [PDF]
OncoImmunology, 2018 Purpose of our study was to explore a new immunotherapy for high grade soft tissue sarcomas (STS) based on cytokine-induced killer cells (CIK) redirected with a chimeric antigen receptor (CAR) against the tumor-promoting antigen CD44v6.
Valeria Leuci +2 more
exaly +6 more sources
Advancing CIK cell immunotherapy: highlights from the second international conference on DC-CIK and CAR-CIK approaches [PDF]
Cancer Immunology, ImmunotherapyOn April 7, 2025, the 2nd International CIK Cell Conference was held in Monza, Italy, marking the establishment of the International Society for CIK Cells (ISCC).
Amit Sharma +11 more
doaj +7 more sources
CD300LG improves the cytotoxic activity of CIK
Central European Journal of Immunology, 2017 To investigate the effect of CD300LG-γ induction on the cytotoxic activity of CIK. Eukaryotic expression plasmid hCD300LG-γ/pEGFP-C3, which can express human CD300LG-γ, was constructed and transfected into CHO cells by lipofectamine.
Qiuyue Wang +6 more
doaj +4 more sources
Innovative Clinical Perspectives for CIK Cells in Cancer Patients [PDF]
International Journal of Molecular Sciences, 2018 Cytokine-induced killer (CIK) cells are T lymphocytes that have acquired, in vitro, following extensive manipulation by Interferon gamma (IFN-γ), OKT3 and Interleukin 2 (IL-2) addition, the expression of several Natural Killer (NK) cell-surface markers.
Martino Introna, Introna Martino
exaly +4 more sources
CIK Cell Therapy for Solid Tumor [PDF]
Nano Biomedicine and Engineering, 2014 In recent years, the clinical trials on applying cytokine induced killer (CIK) cells to solid tumor therapy have been launched worldwide. CIK cells are a heterogeneous subset of ex-vivo expanded T lymphocytes, they present a mixed T-NK phenotype and are endowed with a MHC-unrestricted antitumor activity, which have showed great advantages in clinical ...
Jingjing Zhang, Yao Yang, Hualin Fu
openaire +3 more sources
Cytokine-induced killer (CIK) Cells-associated transcriptome signature reveals the potential immunomodulatory role of TNFSF14 in clear cell renal cell carcinoma [PDF]
Cancer Immunology, ImmunotherapyAmong adoptive immune cell therapies, cytokine-induced killer cell (CIK) therapy has demonstrated clear therapeutic relevance in multiple cancers, particularly clear cell renal cell carcinoma (ccRCC).
Yinhao Chen +9 more
doaj +2 more sources
Dendritic Cell-Cytokine-Induced Killer Cells Co-Loaded with WT1/MUC1/Poly(I:C) Enhance Antitumor Immune Responses In Vitro and In Vivo [PDF]
BiomoleculesDendritic cell-cytokine-induced killer (DC-CIK) therapy faces limitations due to antigenic heterogeneity and suboptimal immune activation. In this study, we developed a multi-antigen-loaded DC-CIK (Ag-DC-CIK) system that co-targets Wilms’ tumor 1 (WT1 ...
Huimin Liu +6 more
doaj +2 more sources
Inhibition of human gastric cancer growth by cytokine-induced killer cells plus chemotherapy with or without cadonilimab in a mouse xenograft tumor model [PDF]
Frontiers in ImmunologyBackgroundCytokine-induced killer (CIK) cell therapy has shown potent antitumor cytotoxicity. To date, no study has evaluated the efficacy and safety of combining CIK cell therapy with chemotherapy, with or without the immune checkpoint inhibitor (ICI ...
Wenwei Yang +4 more
doaj +2 more sources
General Predictions for the Effects of Warming on Competition. [PDF]
Ecol LettWe combined two major theories in ecology to investigate whether warming may have general effects on competition for shared resources. We found that species' niche and fitness differences both decreased with warming, and that competing consumers with highly asymmetrical thermal traits underwent the most dramatic competitive shifts under warming ...
Davis KE +5 more
europepmc +2 more sources
Journal of Immunology Research, 2019 Background. PADI4 has extensive expression in many tumors. This study applied PADI4 as a tumor marker to stimulate DC- (dendritic cell-) CIK (cytokine-induced killer), an immunotherapy approach. Methods. A PADI4 expression plasmid was transfected into EC-
Chunyan Liu +6 more
doaj +2 more sources