Results 31 to 40 of about 9,121 (212)

CIK: A Path to GVL without GVHD? [PDF]

Biology of Blood and Marrow Transplantation, 2011
In allogeneic hematopoietic cell transplantation (HCT), the benefit of graft-versus-leukemia (GVL) effects often comes with the harm of graft-versushost disease (GVHD). In this issue of BBMT, Laport et al. [1] map a possible path toward GVL with a reduced risk of GVHD. GVL effects in humans were originally documented in observational studies by showing
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Development of the Collective Interaction Klystron (CIK) [PDF]

Proceedings of the 1989 IEEE Particle Accelerator Conference, . 'Accelerator Science and Technology, 2003
The CIK is a microwave source which relies on the negative mass instability for electron bunching, as opposed to the linear-drift ballistic bunching of conventional klystrons. A proof-of-principle (POP) CIK is being tested to verify the predictions of analyses, which indicate that the CIK is feasible in the 2-10-GHz region at megawatt to gigawatt power
J.A. Pasour, T.P. Hughes, K. Thomason
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Cytokine-induced killer cell delivery enhances the antitumor activity of oncolytic reovirus. [PDF]

PLoS ONE, 2017
Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing untransformed cells.
Xing Zhao, Weiwei Ouyang, Cariad Chester, Shiqi Long, Nianxue Wang, Zhixu He   +5 more
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Inhibition of human gastric cancer growth by cytokine-induced killer cells plus chemotherapy with or without cadonilimab in a mouse xenograft tumor model

Frontiers in Immunology
BackgroundCytokine-induced killer (CIK) cell therapy has shown potent antitumor cytotoxicity. To date, no study has evaluated the efficacy and safety of combining CIK cell therapy with chemotherapy, with or without the immune checkpoint inhibitor (ICI ...
Wenwei Yang, Jingwei Liu, Tiantian Hou, Xu Lu, Lin Yang   +4 more
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Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells

Clinical and Developmental Immunology, 2011
Previous reports have suggested that treatment with cytokine-induced killer (CIK) cells may benefit patients with various types of tumor. The aim of this study was to evaluate the antitumor effects of CIK cells against the colorectal cancer line SW1116 ...
Yao Wang, Hanren Dai, Hong Li, Haiyan Lv, Tao Wang, Xiaobing Fu, Weidong Han   +6 more
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Combinatorial approach with Cytokine-Induced Killer (CIK) cells and immunotools to fight HER2-positive breast cancer. Culture optimization of CIK cell expansion and function.

, 2023
reservedTargeting HER2 molecules for HER2+ breast cancer has become the standard care for both early and advanced-stage disease, on the other hand the treatment of metastatic HER+ tumors that develop resistance and lead to a disease progression, remained
NGO, TRONG HIEU
core  

Role of the adaptor protein CIKS in the activation of the IKK complex [PDF]

Biochemical and Biophysical Research Communications, 2003
Nuclear factor kappaB (NF-kappaB) plays a pivotal role in numerous cellular processes, including stress response, inflammation, and protection from apoptosis. Therefore, the activity of NF-kappaB needs to be tightly regulated. We have previously identified a novel gene, named CIKS (connection to IkappaB-kinase and SAPK), able to bind the regulatory sub-
MAURO C, VITO P, MELLONE S, PACIFICO F, CHARIOT A, FORMISANO, SILVESTRO, LEONARDI, ANTONIO   +6 more
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Combining antiangiogenic therapy with adoptive cell immunotherapy exerts better antitumor effects in non-small cell lung cancer models. [PDF]

PLoS ONE, 2013
INTRODUCTION: Cytokine-induced killer cells (CIK cells) are a heterogeneous subset of ex-vivo expanded T lymphocytes which are characterized with a MHC-unrestricted tumor-killing activity and a mixed T-NK phenotype.
Shujing Shi, Rui Wang, Yitian Chen, Haizhu Song, Longbang Chen, Guichun Huang   +5 more
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PD-L1 expression is a predictive biomarker for CIK cell-based immunotherapy in postoperative patients with breast cancer

Journal for ImmunoTherapy of Cancer, 2019
Background A sequential combination of radiochemotherapy/endocrinotherapy and cytokine-induced killer cell (CIK) infusion has been shown to be an effective therapy for post-mastectomy breast cancer based on statistical analysis of the patient population.
Zi-Qi Zhou, Jing-Jing Zhao, Qiu-Zhong Pan, Chang-Long Chen, Yuan Liu, Yan Tang, Qian Zhu, De-Sheng Weng, Jian-Chuan Xia   +8 more
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The Efficacy of CIK-Based Immunotherapies for Advanced Solid Tumors [PDF]

Technology in Cancer Research & Treatment, 2016
Objective: To investigate the efficacy of cytokine-induced killer cell-based immunotherapies in patients with advanced malignant solid tumors and the difference in clinical efficiency among 3 kinds of cytokine-induced killer cell-based immunotherapies ...
Hongjin, Chu, Fengcai, Du, Lixin, Jiang, Zhixin, Wang, Zhaohua, Gong, Peiwen, Lian, Peng, Li, Jian, Chen   +7 more
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