Results 41 to 50 of about 56,100 (193)

Primal-dual variable neighborhood search for the simple plant-location problem [PDF]

, 2007
Copyright @ 2007 INFORMSThe variable neighborhood search metaheuristic is applied to the primal simple plant-location problem and to a reduced dual obtained by exploiting the complementary slackness conditions.
Brimberg, J, Hansen, P, Mladenović, N, Urosevic, D   +3 more
core   +1 more source

PD-L1 expression is a predictive biomarker for CIK cell-based immunotherapy in postoperative patients with breast cancer

Journal for ImmunoTherapy of Cancer, 2019
Background A sequential combination of radiochemotherapy/endocrinotherapy and cytokine-induced killer cell (CIK) infusion has been shown to be an effective therapy for post-mastectomy breast cancer based on statistical analysis of the patient population.
Zi-Qi Zhou, Jing-Jing Zhao, Qiu-Zhong Pan, Chang-Long Chen, Yuan Liu, Yan Tang, Qian Zhu, De-Sheng Weng, Jian-Chuan Xia   +8 more
doaj   +1 more source

Combined therapy with cytokine-induced killer cells and oncolytic adenovirus expressing IL-12 induce enhanced antitumor activity in liver tumor model. [PDF]

PLoS ONE, 2012
Both adoptive immunotherapy and gene therapy hold a great promise for treatment of malignancies. However, these strategies exhibit limited anti-tumor activity, when they are used alone.
Zhi Yang, Qianzhen Zhang, Ke Xu, Juanjuan Shan, Junjie Shen, Limei Liu, Yanmin Xu, Feng Xia, Ping Bie, Xia Zhang, Youhong Cui, Xiu-Wu Bian, Cheng Qian   +12 more
doaj   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, EarlyView.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

CIKS/Act1-Mediated Signaling by IL-17 Cytokines in Context: Implications for How a CIKS Gene Variant May Predispose to Psoriasis [PDF]

The Journal of Immunology, 2012
Abstract Psoriasis is a relapsing skin disease characterized by abnormal keratinocyte proliferation and differentiation and by an influx of inflammatory immune cells. Recently, IL-17 cytokines have been strongly implicated as critical for the pathogenesis of this disease.
Søren Ulrik, Sønder, Andrea, Paun, Hye-Lin, Ha, Peter F, Johnson, Ulrich, Siebenlist   +4 more
openaire   +2 more sources

Observation of Excitonic Instability in a Monolayer Ta2NiSe5 With Strain Disorder

Advanced Science, EarlyView.
Monolayer Ta2${\rm Ta}_2$NiSe5${\rm NiSe}_5$ sustains an excitonic insulating phase up to 190 K, with Raman signatures of gap opening and critical excitonic fluctuations. Thickness‐independent large gap ratios highlight strong exciton‐phonon coupling, while substrate‐induced strain disorder depresses Tc, establishing monolayer Ta2${\rm Ta}_2$NiSe5${\rm
So Young Kim, Kwangrae Kim, Dowook Kim, Ji Eun Lee, Jieun Seok, Chang Il Kwon, Jo Hyun Yun, Chang‐Jong Kang, Jae Hoon Kim, H. W. Yeom, Tae‐Hwan Kim, Jonghwan Kim, B. J. Kim, Jun Sung Kim   +13 more
wiley   +1 more source

Effect of dendritic cell-cytokine-induced killer cells in patients with advanced colorectal cancer combined with first-line treatment

World Journal of Surgical Oncology, 2017
Background Surgical resection combined with adjuvant chemotherapy is considered as the gold-standard treatment for advanced colorectal cancer patients. These patients have a poor 5-year survival rate of 5% or less.
Yunqing Xie, Lijie Huang, Luchuan Chen, Xiaowei Lin, Li Chen, Qiuhong Zheng   +5 more
doaj   +1 more source

Electroencephalogram‐Driven Recognition of Parkinson's Disease Through a Mycelium‐Inspired Memristive Reservoir Computing Circuit

Advanced Intelligent Systems, EarlyView.
This work presents a bio‐inspired computing framework for Parkinson's disease analog recognition using electroencephalogram signals. Temporally encoded EEG features stimulate a mycelium‐inspired memristive reservoir, where disease‐related patterns emerge through physical spatiotemporal dynamics.
Ioannis K. Chatzipaschalis, Ioannis Tompris, Pantelis Fraidakis, Iosif‐Angelos Fyrigos, Antonio Rubio, Georgios Ch. Sirakoulis   +5 more
wiley   +1 more source

Autologous CIK cells combined with chemotherapy as the first-line treatment for locally advanced or metastatic gastric cancer is safe and feasible

Frontiers in Immunology, 2023
AimTo evaluate the safety and initial efficacy of autologous cytokine-induced killer (CIK) cells combined with S-1+oxaliplatin (SOX) as the first-line treatment for locally advanced or metastatic gastric cancer (GC).Materials and methodsIn this two-arm ...
Xiaoting Ma, Liming Peng, Junqing Wang, Lizhen Gao, Wen Zhang, Xu Lu, Jingwei Liu, Lin Yang   +7 more
doaj   +1 more source

A timing attack on the CIKS-1 block cipher [PDF]

Canadian Conference on Electrical and Computer Engineering, 2005., 2005
The use of data-dependent transformations has been an area of increasing interest for the designers of ciphers. In particular, data-dependent permutations (DDPs) provide a fast and simple cryptologic primitive when implemented in hardware. However, when a DDP block is naively implemented in software, it can reveal information about the Hamming weight ...
M. Furlong, H. Heys
openaire   +1 more source