Results 51 to 60 of about 3,955 (172)

Autologous CIK cells combined with chemotherapy as the first-line treatment for locally advanced or metastatic gastric cancer is safe and feasible

Frontiers in Immunology, 2023
AimTo evaluate the safety and initial efficacy of autologous cytokine-induced killer (CIK) cells combined with S-1+oxaliplatin (SOX) as the first-line treatment for locally advanced or metastatic gastric cancer (GC).Materials and methodsIn this two-arm ...
Xiaoting Ma, Liming Peng, Junqing Wang, Lizhen Gao, Wen Zhang, Xu Lu, Jingwei Liu, Lin Yang   +7 more
doaj   +1 more source

U.S. Multinational Corporations’ Initial Income‐Shifting Response to the TCJA

Journal of Corporate Accounting &Finance, EarlyView.
ABSTRACT I find U.S. multinational corporations (MNCs) responded to the Tax Cuts and Jobs Act (TCJA) of 2017 by increasing income shifted to foreign sources in the first two years following the effective date. Financially constrained MNCs increased income shifting more, while higher operational uncertainty MNCs increased income shifting less than other
Tyler P. Johnson
wiley   +1 more source

Revenue Recognition Comparability and Analysts’ Disclosure Processing Costs

Journal of Accounting Research, EarlyView.
ABSTRACT I examine whether the FASB's revenue recognition guidance under ASC 606 influences revenue comparability across firms and industries and whether revenue comparability reduces analysts’ disclosure processing costs. I extract firms’ revenue policy disclosures from 10‐K filings to measure their textual similarity and compare revenue policies ...
ANDREA TILLET
wiley   +1 more source

Cytokine-induced killer (CIK) cells inhibit Plasmodium falciparum parasitemia through cytolytic effector activity in vitro

Immunobiology
Cytokine-induced killer (CIK) cells, with dual traits resembling natural killer (NK) and T cells, have shown a promising clinical efficacy against cancer in clinical application leading to licensing of CIK cells in many countries.
Rohulla Vaseq, Berthila Ferkamchwi, Hans Weiher, Veronika Lukacs-Kornek, Nahid Mahleqa, Marc P. Hübner, Amit Sharma, Ingo G.H. Schmidt-Wolf   +7 more
doaj   +1 more source

Observable Versus Unobservable Information Acquisition: The Differential Effect on Information Acquisition and Market Quality

Accounting &Finance, EarlyView.
ABSTRACT Historically, investors' information acquisition has been unobservable, but recent regulatory changes have made these activities visible to other market participants. Using this shift, we provide empirical evidence that investors strategically reduce their information acquisition when they expect their actions to be observed.
Eunyoung Lee, Joo Hyung Lee
wiley   +1 more source

Autologous Cytokine-Induced Killer Cell Immunotherapy Enhances Chemotherapy Efficacy against Multidrug-Resistant Tuberculosis

Journal of Immunology Research, 2022
Objective. Multidrug-resistant tuberculosis (MDR-TB) causes persistent infection and challenges tuberculosis control worldwide. T cell-mediated immunity plays a critical role in controlling Mycobacterium tuberculosis (Mtb) infection, and therefore ...
Peijun Tang, Xingnian Chen, Junchi Xu, Yunlong Hu, Zhijian Ye, Xiafang Wang, Yumei Xiao, Xinghua Shen, Jianping Zhang, Yanjun Feng, Cuilin Shi, Xin Yu, Lixian Yi, Xinchun Chen, Binfeng Lu, Ping Xu, Zhongwen Sun, Meiying Wu   +17 more
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Dendritic cells decreased the concomitant expanded Tregs and Tregs related IL-35 in cytokine-induced killer cells and increased their cytotoxicity against leukemia cells.

PLoS ONE, 2014
Regulatory T cells (Tregs) are potent immunosuppressive cells and essential for inducing immune tolerance. Recent studies have reported that Tregs and Tregs related cytokines can inhibit the antitumor activity of cytokine-induced killer (CIK) cells, but ...
Ying Pan, Qianshan Tao, Huiping Wang, Shudao Xiong, Rui Zhang, Tianping Chen, Lili Tao, Zhimin Zhai   +7 more
doaj   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Efficacy of Cytokine-Induced Killer Cell Immunotherapy for Patients With Pathologically Pure Glioblastoma

Frontiers in Oncology, 2022
The most common malignant central nervous system tumor is glioblastoma multiforme (GBM). Cytokine-induced killer (CIK) cell therapy is a promising type of adoptive cell immunotherapy for various cancers.
Myung-Hoon Han, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Gun He Nam, Choong Hyun Kim   +6 more
doaj   +1 more source