Results 141 to 150 of about 19,567 (308)
The FEBS Journal, Volume 292, Issue 9, Page 2173-2188, May 2025.Mitogen‐activated protein kinases (MAPKs) regulate various cellular processes, including proliferation, differentiation, and motility. Alterations in these signalling pathways can lead to various diseases, including cancer. The atypical MAPKs ERK3 (MAPK6), ERK4 (MAPK4), ERK7/8 (MAPK15) and NLK have long been neglected in kinomic studies.
Katrin Dahm +4 more
wiley +1 more source
Health Science Reports, Volume 8, Issue 4, April 2025.ABSTRACT Background and Aims Tobacco and betel quid are two major causes of oral squamous cell carcinoma (OSCC). Tumor biomarkers offer potential headway for improved diagnosis of OSCC caused by tobacco and betel quid. Currently, several empirical investigations have explored the use of diverse types of tumor biomarkers in the diagnosis of tobacco‐ and
Yovanthi Anurangi Jayasinghe +4 more
wiley +1 more source
Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients
Frontiers in Molecular BiosciencesThe heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E250Q
Jessica M. Adams +5 more
doaj +1 more source
Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model
Cells, 2019 Syne-2 (also known as Nesprin-2) is a member of a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments.
Nathalie Falk +7 more
doaj +1 more source
Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis [PDF]
, 2015 ©2015. To investigate the contribution of ion channels to ciliogenesis, we carried out a small interfering RNA (siRNA)-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells.
Den Ouden, K. +13 more
core +3 more sources
Methods to Assess Neuronal Primary Cilia Electrochemical Signaling
Journal of Cellular Physiology, Volume 240, Issue 4, April 2025.Hippocampal neuron primary cilia are illuminated with a fluorescent biosensor. ABSTRACT Primary cilia are polymodal sensory organelles which project from the apical side of polarized cells. They are found in all brain hemispheres but are most pronounced in neurons, which comprise the granular layers of the hippocampus and cerebellum.
Paul G. DeCaen, Louise F. Kimura
wiley +1 more source
Primary cilia and actin regulatory pathways in renal ciliopathies
Frontiers in NephrologyCiliopathies are a group of rare genetic disorders caused by defects to the structure or function of the primary cilium. They often affect multiple organs, leading to brain malformations, congenital heart defects, and anomalies of the retina or skeletal ...
Rita Kalot +6 more
doaj +1 more source
Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis
Cells, 2015 Centrosomes are major microtubule-organizing centers of animal cells that consist of two centrioles. In mitotic cells, centrosomes are duplicated to serve as the poles of the mitotic spindle, while in quiescent cells, centrosomes move to the apical ...
Shubhra Majumder +2 more
doaj +1 more source
Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton [PDF]
, 2013 Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing ...
Adam V. Kwiatkowski +74 more
core +4 more sources