Results 151 to 160 of about 19,567 (308)
Clinical and Translational Science, Volume 18, Issue 4, April 2025.ABSTRACT Second‐generation antipsychotics (SGA) are widely used for treating psychiatric disorders; however, their use is associated with an increased risk of metabolic syndrome (MetS). To identify common genetic associations of SGA‐induced metabolic syndrome (SGA‐MetS), we conducted a genome‐wide association study (GWAS) in a diverse patient ...
Nihal El Rouby +8 more
wiley +1 more source
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth [PDF]
, 2019 Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1)
Balducci, Silvia +14 more
core +1 more source
Nature Communications, 2020 Exon junction complexes (EJCs) mark untranslated spliced mRNAs and are crucial for the mRNA lifecycle. An imbalance in EJC dosage alters mouse neural stem cell (mNSC) division and is linked to human neurodevelopmental disorders.
Oh Sung Kwon +9 more
semanticscholar +1 more source
Targeting Primary Ciliogenesis with Small-Molecule Inhibitors
Cell Chemical Biology, 2020 The primary cilium is generally a non-motile solitary organelle that protrudes from a basal body at the cell surface in various cell types in multicellular organisms. This microtubule-based structure acts as a cell signaling platform to control key cellular processes, including cell proliferation and differentiation in development and in adult tissues.
Guen, Vincent J, Prigent, Claude
openaire +5 more sources
The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis [PDF]
, 2016 A primary cilium is present on most eukaryotic cells and represents a specialized organelle dedicated to signal transduction and mechanosensing. Defects in cilia function are the cause for several human diseases called ciliopathies.
A Doyotte +50 more
core +1 more source
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]
, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Kirschner, Marc W +2 more
core +1 more source
High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. [PDF]
, 2020 Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-cateninY489) emerges during human squamous lung cancer progression ...
Aros, Cody J +13 more
core +1 more source
Common themes in centriole and centrosome movements. [PDF]
, 2013 addresses: School of Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.Copyright © 2011 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Cell Biology.
Allen +101 more
core +1 more source
Oestrogen signalling drives ciliogenesis in human endometrial organoids.
Endocrinology, 2019 The human endometrium is the inner lining of the uterus consisting of stromal and epithelial (secretory and ciliated) cells. It undergoes a hormonally regulated monthly cycle of growth, differentiation and desquamation.
S. Haider +10 more
semanticscholar +1 more source
The Trp73 Mutant Mice: A Ciliopathy Model That Uncouples Ciliogenesis From Planar Cell Polarity
Frontiers in Genetics, 2019 p73 transcription factor belongs to one of the most important gene families in vertebrate biology, the p53-family. Trp73 gene, like the other family members, generates multiple isoforms named TA and DNp73, with different and, sometimes, antagonist ...
Margarita M. Marques +4 more
doaj +1 more source