Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis
Cells, 2015 Centrosomes are major microtubule-organizing centers of animal cells that consist of two centrioles. In mitotic cells, centrosomes are duplicated to serve as the poles of the mitotic spindle, while in quiescent cells, centrosomes move to the apical ...
Shubhra Majumder +2 more
doaj +1 more source
Short coiled‐coil proteins from plants and metazoans – the ‘jacks of all trades’
The FEBS Journal, Volume 292, Issue 23, Page 6195-6206, December 2025.Short coiled‐coil proteins from plants and metazoans—true ‘jacks of all trades’—play supporting but crucial roles in cellular stress response, metabolism, autophagy, and membrane dynamics. Despite their small size and modest sequence conservation, proteins like plant LSUs and metazoan SCOCs showcase remarkable functional versatility shaped by evolution,
Agnieszka Sirko +2 more
wiley +1 more source
A homozygous genome‐edited Sept2‐EGFP fibroblast cell line [PDF]
, 2019 Septins are a conserved, essential family of GTPases that interact with actin, microtubules, and membranes and form scaffolds and diffusion barriers in cells. Several of the 13 known mammalian septins assemble into nonpolar, multimeric complexes that can
Banko, Monika +4 more
core +1 more source
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome [PDF]
, 2017 WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood.
Caligioni CS +22 more
core +3 more sources
Deficiency of calpain-6 inhibits primary ciliogenesis
BMB Reports, 2019 The primary cilium is a microtubule-based structure projecting from a cell. Although the primary cilium shows no motility, it can recognize environmental stimuli. Thus, ciliary defects cause severe abnormalities called ciliopathies. Ciliogenesis is a very complex process and involves a myriad of components and regulators. In order to excavate the novel
Kim, Bo Hye +6 more
openaire +3 more sources
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation
EMBO Reports, 2019 Centriolar satellites are ubiquitous in vertebrate cells. They have recently emerged as key regulators of centrosome/cilium biogenesis, and their mutations are linked to ciliopathies.
Ezgi Odabasi +3 more
semanticscholar +1 more source
Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients
Frontiers in Molecular BiosciencesThe heterodimeric kinesin-2 motor (KIF3A/KIF3B with accessory protein KAP3) drives intraflagellar transport, essential for ciliogenesis and ciliary function. Three point mutations in the KIF3B subunit have recently been linked to disease in humans (E250Q
Jessica M. Adams +5 more
doaj +1 more source
Resting cells rely on the DNA helicase component MCM2 to build cilia [PDF]
, 2019 Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number of MCM hexamers greatly exceeds the number of firing origins suggesting additional roles of MCMs. Here we
Alcantara +106 more
core +1 more source
Apico-basal polarity determinants encoded by crumbs genes affect ciliary shaft protein composition, IFT movement dynamics, and cilia length [PDF]
, 2017 One of the most obvious manifestations of polarity in epithelia is the subdivision of the cell surface by cell junctions into apical and basolateral domains. crumbs genes are among key regulators of this form of polarity. Loss of crumbs function disrupts
Hazime, K., Malicki, J.J.
core +1 more source