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Prostaglandin signaling in ciliogenesis and development
Journal of Cellular Physiology, 2021Prostaglandin (PG) signaling regulates a wide variety of physiological and pathological processes, including body temperature, cardiovascular homeostasis, reproduction, and inflammation.
Daqing Jin, T. Zhong
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JNK regulates ciliogenesis through the interflagellar transport complex and actin networks
Journal of Cell Biology, 2023Chatzifrangkeskou et al. show that c-Jun N-terminal kinase (JNK) is found at the base of motile and primary cilia, in association with the basal bodies.
M. Chatzifrangkeskou +2 more
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Ciliogenesis and ciliary abnormalities
Medical Electron Microscopy, 2000Cilia are motile processes extending from the basal bodies, playing important roles in the mucociliary clearance in the respiratory tract and the transport of the ovum from the ovary to the uterus in mammals. Ciliogenesis is divided into four stages: (1) duplication of centrioles; (2) migration of centrioles to the apical cell surface to become basal ...
H, Hagiwara +3 more
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Nature Cell Biology, 2014
ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.
Pascal, Barbry +1 more
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ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.
Pascal, Barbry +1 more
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Ciliogenesis: building the cell's antenna
Nature Reviews Molecular Cell Biology, 2011The cilium is a complex organelle, the assembly of which requires the coordination of motor-driven intraflagellar transport (IFT), membrane trafficking and selective import of cilium-specific proteins through a barrier at the ciliary transition zone.
Hiroaki, Ishikawa, Wallace F, Marshall
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Protocols to induce and study ciliogenesis
2023Primary cilia (PC) are sensory organelles that function as cellular antennas, transmitting signals between the extracellular and intracellular spaces in many vertebrate tissues. The cell generates and assembles PC through a highly regulated process called ciliogenesis.
Paula, Moreno-Cruz +4 more
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Development of order during ciliogenesis
The Anatomical Record, 1968AbstractThis report consists of an electron microscope study of developing cilia in nasal epithelium of 15–18 day mouse embryos. As soon as recognizable cilia were observed, the typical 9 + 2 pattern of ciliary microtubule pairs was present. However, at this stage the intracellular spatial alignment of adjacent cilia, reflected in the adult by ...
D, Frisch, A I, Farbman
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How CEP164 ciliopathy mutations impair ciliogenesis
Structure, 2022CEP164 recruits TTBK2 to the distal end of centrioles to allow primary cilium formation. In this issue of Structure, Rosa e Silva et al. (2022) present co-crystallized structures that show the molecular basis of this recruitment and define how ciliopathy mutations in CEP164 disrupt the CEP164-TTBK2 complex.
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Abstract 3252: Tumor treating fields suppression of ciliogenesis enhances temozolomide toxicity
Cancer Research, 2022Tumor Treating Fields (TTFields) are low intensity, alternating intermediate frequency (200kHz) electrical fields that extend survival of glioblastoma patients receiving maintenance temozolomide (TMZ) chemotherapy. How TTFields exert efficacy on cancer
P. Shi +6 more
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