Results 21 to 30 of about 15,550 (253)

Cilostazol-induced acute tubulointerstitial nephritis accompanied by IgA nephropathy: a case report

BMC Nephrology, 2018
Background Cilostazol is an antiplatelet drug that is widely prescribed for the prevention of secondary stroke. Adverse reactions to cilostazol include headaches, palpitations, and diarrhea. Little is known about the nephrotoxicity of cilostazol, such as
Hisato Shima, Manabu Tashiro, Satoshi Yamada, Motokazu Matsuura, Kazuyoshi Okada, Toshio Doi, Jun Minakuchi, Shu Kawashima   +7 more
doaj   +1 more source

Cilostazol prevents endothelin-induced smooth muscle constriction and proliferation. [PDF]

PLoS ONE, 2012
Cilostazol is a phosphodiesterase inhibitor that has been shown to inhibit platelet activation. Endothelin is known to be the most potent endogenous growth promoting and vasoactive peptide.
Yoshifumi Kawanabe, Maki Takahashi, Xingjian Jin, Shakila Abdul-Majeed, Andromeda M Nauli, Youssef Sari, Surya M Nauli   +6 more
doaj   +1 more source

Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke:Pooled analysis of randomized trials [PDF]

, 2015
Background and Purpose: Lacunar stroke accounts for ≈25% of ischemic stroke, but optimal antiplatelet regimen to prevent stroke recurrence remains unclear.
Benavente, Oscar R., Copley, Hannah Charlotte, Kwok, Chun Shing, Loke, Yoon K., Myint, Phyo Kyaw, Shoamanesh, Ashkan   +5 more
core   +1 more source

Cilostazol Suppresses IL-23 Production in Human Dendritic Cells via an AMPK-Dependent Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: Cilostazol has been previously demonstrated to inhibit IL-23 production in human synovial macrophages via a RhoA/ROCK-dependent pathway.
Quanxing Shi, Zhao Yin, Peilin Liu, Bei Zhao, Zhong Zhang, Shuai Mao, Tengfei Wei, Mengmeng Rao, Liguo Zhang, Shouli Wang   +9 more
doaj   +1 more source

Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells. [PDF]

PLoS ONE, 2015
Autophagy is a vital pathway for the removal of β-amyloid peptide (Aβ) and the aggregated proteins that cause Alzheimer's disease (AD). We previously found that cilostazol induced SIRT1 expression and its activity in neuronal cells, and thus, we ...
Hye Rin Lee, Hwa Kyoung Shin, So Youn Park, Hye Young Kim, Sun Sik Bae, Won Suk Lee, Byung Yong Rhim, Ki Whan Hong, Chi Dae Kim   +8 more
doaj   +1 more source

Cilostazol reduces restenosis after carotid artery stenting [PDF]

, 2010
BACKGROUND: Although carotid artery stenting (CAS) has been proposed as an alternative to carotid endarterectomy in cerebral revascularization, restenosis remains an unsolved issue.
Hayakawa Mikito, Matsumaru Yuji, Matsumura Akira, Nemoto Shigeru, Takigawa Tomoji, 松村 明, 滝川 知司   +6 more
core   +1 more source

Cilostazol Induces PGI2 Production via Activation of the Downstream Epac-1/Rap1 Signaling Cascade to Increase Intracellular Calcium by PLCε and to Activate p44/42 MAPK in Human Aortic Endothelial Cells.

PLoS ONE, 2015
BackgroundCilostazol, a selective phosphodiesterase 3 (PDE3) inhibitor, is known as an anti-platelet drug and acts directly on platelets. Cilostazol has been shown to exhibit vascular protection in ischemic diseases. Although vascular endothelium-derived
Ayako Hashimoto, Michinori Tanaka, Satoshi Takeda, Hideki Ito, Keisuke Nagano   +4 more
doaj   +1 more source

ESVM Guideline on peripheral arterial disease [PDF]

, 2019
International ...
, , , Belch, Jill, Boc, Vinko, Brodmann, Marianne, Bulvas, Miroslav, Canning, Caitriona, Carpentier, Patrick H., Chraim, Ali, Colgan, Mary-Paula, Dimakakos, Evangelos, Dorigo, Walter, Frank, Ulrich, Gottsäter, Anders, Heiss, Christian, Houston, Graeme, Kahan, Thomas, Lawall, Holger, Lindstedt, Isak, Madaric, Juraj, Mahe, Guillaume, Martini, Romeo, Mazzolai, Lucia, Nikol, Sigrid, Olinic, Dan Mircea, Pernod, Giles, Poredoš, Pavel, Przywara, Stanislaw, Pécsvárady, Zsolt, Quéré, Isabelle, Righini, Marc, Roztocil, Karel, Schlager, Oliver, Stanek, Agata, Terlecki, Piotr, Vasic, Dragan, Visonà, Adriana, Wautrecht, Jean-Claude   +38 more
core   +5 more sources

Determination of cilostazol and its active metabolite 3,4-dehydro cilostazol from small plasma volume by UPLC−MS/MS

Journal of Pharmaceutical Analysis, 2015
A simple, rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC−MS/MS) method has been developed for the simultaneous determination of cilostazol and its pharmacologically active metabolite 3,4-dehydro cilostazol in
Nejal M. Bhatt, Vijay D. Chavada, Daxesh P. Patel, Primal Sharma, Mallika Sanyal, Pranav S. Shrivastav   +5 more
doaj   +1 more source

Effects of ischemic preconditioning and cilostazol on muscle ischemia-reperfusion injury in rats [PDF]

, 2014
PURPOSE: To evaluate effects of ischemic preconditioning and Cilostazol on muscle ischemia-reperfusion injury.METHODS: Male Wistar rats were submitted to muscle ischemic and reperfusion injury (4h of the left common iliac artery occlusion followed by 1h ...
Frias Neto, Carlos Alberto da Silva, Koike, Marcia Kiyomi, Montero, Edna Frasson de Souza, Saad, Karen Ruggeri, Saad, Paulo Fernandes   +4 more
core   +3 more sources