Results 11 to 20 of about 12,244 (184)

Case Report: Oral Cimetidine Administration Causes Drug-Induced Immune Hemolytic Anemia by Eliciting the Production of Cimetidine-Dependent Antibodies and Drug-Independent Non-specific Antibodies

Frontiers in Medicine, 2021
Previously, it was reported that multiple patients had hemolytic anemia associated with cimetidine administration, while only one patient who had received intravenous cimetidine was serologically diagnosed with drug-induced immune hemolytic anemia (DIIHA)
Yuanjun Wu, Yong Wu, Yanli Ji, Yanhui Liu, Dongsheng Wu, Jiajie Liang, Ganping Guo, Baochan Chen   +7 more
doaj   +1 more source

Ameliorative Effect of Cimetidine and Silymarin on Acute Acetaminophen-induced Hepatotoxicity in Adult Albino Rats: An Experimental Comparative Study [PDF]

The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2019
Acetaminophen is an analgesic and antipyretic drug, its overdose cause hepatotoxicity. The current antidote for acetaminophen hepatotoxicity is N-acetyl cysteine (NAC); however, NAC has been resulted in severe side effects as seizures, intracranial ...
Rabab F. Hindawy, Abdelmonem G. Madboly, Eslam S. Metwally, Atef Fouda, asmaa abdelaziz soliman   +4 more
doaj   +1 more source

Pengaruh Jus Buah Pepaya (Carica papaya L.) terhadap Profil Farmakokinetik Simetidin pada Tikus Putih (Rattus norvegicus)

Journal of Tropical Pharmacy and Chemistry, 2016
Drugs used with foods or drinks can affect the drug effects. This study aims to observe the effect of papaya juice (Carica papaya L.) to the pharmacokinetics profile of cimetidine in white rats. The animal were randomly in three group.
Siti Julaicha, Adam M. Ramadhan, Rolan Rusli   +2 more
doaj   +1 more source

Cimetidine-induced Male Reproductive Defects in Piroxicam-induced Gastric Ulcerated Wistar Rats and Their Amelioration by Melatonin [PDF]

The Iranian Journal of Veterinary Science and Technology
Cimetidine is a known reproductive toxicant due to its adverse effects on testicular function. Melatonin is an antioxidant that has a role in mitigating any disorders that could affect spermatogenesis.
Afisu Basiru, Oluwatobi Adetunji, Ganiu Akorede, Abdulfatai Aremu, Abdullahi Ishola, Aishat Olatunji   +5 more
doaj   +1 more source

Vitamin B12-induced spermatogenesis recovery in cimetidine-treated rats: effect on the spermatogonia number and sperm concentration

Asian Journal of Andrology, 2017
The H2-receptor antagonist cimetidine is an antiulcer drug also used for the treatment of cancer due to its antiangiogenic effect. However, this drug has caused structural changes in the seminiferous tubules.
Flávia L Beltrame, Estela Sasso-Cerri
doaj   +1 more source

Cimetidine Enhances Antigen-Specific IgE and Th2 Cytokine Production

Allergology International, 2011
Background: Treatment with anti-ulcer drugs has been shown to enhance IgE production against food antigens. However, little is known about the immunological effects of cimetidine, a histamine receptor type 2 (H2R) antagonist that is widely used as an ...
Ken Arae, Keisuke Oboki, Tatsukuni Ohno, Masako Hirata, Susumu Nakae, Haruhiko Taguchi, Hirohisa Saito, Toshiharu Nakajima   +7 more
doaj   +1 more source

Cimetidine Pharmacodynamics and Pharmacokinetics in Healthy Subjects: A Comparison of Tablets and Suspension

Canadian Journal of Gastroenterology, 1994
The objective of this study was to compare the effect of cimetidine 200 mg tablet with that of cimetidine suspension (200 mg/10 mL), a 20 mL suspension of 800 mg magnesium hydroxide and 912 mg aluminum hydroxide, and matching placebo on intragastric pH ...
ABR Thomson, P Kirdeikis, L Zuk, RE Samuels, P Zarevics   +4 more
doaj   +1 more source

Effects of temperature and wavelength choice on in-situ dissolution test of Cimetidine tablets

Journal of Pharmaceutical Analysis, 2013
The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance (A)
Xin-Xia Li, Yan Wang, Ping-Ping Xu, Qi-Zhou Zhang, Kun Nie, Xu Hu, Bin Kong, Li Li, Jian Chen   +8 more
doaj   +1 more source

Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine

Pharmaceutics, 2018
A sensitive and simple chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to evaluate memantine in rat plasma. Memantine and propranolol (internal standard) in rat plasma was extracted using a methanol precipitation method.
Young A. Choi, Im-Sook Song, Min-Koo Choi   +2 more
doaj   +1 more source

Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats

Pharmaceutics, 2019
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion.
Yoo-Seong Jeong, Anusha Balla, Kwang-Hoon Chun, Suk-Jae Chung, Han-Joo Maeng   +4 more
doaj   +1 more source