Results 21 to 30 of about 15,425 (224)

Cimetidine-induced Male Reproductive Defects in Piroxicam-induced Gastric Ulcerated Wistar Rats and Their Amelioration by Melatonin [PDF]

The Iranian Journal of Veterinary Science and Technology
Cimetidine is a known reproductive toxicant due to its adverse effects on testicular function. Melatonin is an antioxidant that has a role in mitigating any disorders that could affect spermatogenesis.
Afisu Basiru, Oluwatobi Adetunji, Ganiu Akorede, Abdulfatai Aremu, Abdullahi Ishola, Aishat Olatunji   +5 more
doaj   +1 more source

Vitamin B12-induced spermatogenesis recovery in cimetidine-treated rats: effect on the spermatogonia number and sperm concentration

Asian Journal of Andrology, 2017
The H2-receptor antagonist cimetidine is an antiulcer drug also used for the treatment of cancer due to its antiangiogenic effect. However, this drug has caused structural changes in the seminiferous tubules.
Flávia L Beltrame, Estela Sasso-Cerri
doaj   +1 more source

Effects of temperature and wavelength choice on in-situ dissolution test of Cimetidine tablets

Journal of Pharmaceutical Analysis, 2013
The effects of temperature and wavelength choice on in-situ dissolution test instrument of Cimetidine were studied. Absorbance (A)
Xin-Xia Li, Yan Wang, Ping-Ping Xu, Qi-Zhou Zhang, Kun Nie, Xu Hu, Bin Kong, Li Li, Jian Chen   +8 more
doaj   +1 more source

A DFT study of the chemical reactivity of cimetidine A, C and D in the gas, H2O, MeOH and EtOH solvents [PDF]

Journal of the Serbian Chemical Society, 2017
% Fukui % DFT s KR nema In the present work, we have analyzed the chemical reactivity of cimetidine A, C and D in different solvents; through the evaluation of global and local DFT reactivity descriptors.
Mendoza Huizar Luis Humberto, Salgado-Morán Guillermo, Cardona-Villada Wilson, Pacheco Alison Geraldo, Glossman-Mitnik Daniel   +4 more
doaj   +1 more source

Physiologically-Based Pharmacokinetic Modeling for Drug-Drug Interactions of Procainamide and N-Acetylprocainamide with Cimetidine, an Inhibitor of rOCT2 and rMATE1, in Rats

Pharmaceutics, 2019
Previous observations demonstrated that cimetidine decreased the clearance of procainamide (PA) and/or N-acetylprocainamide (NAPA; the primary metabolite of PA) resulting in the increased systemic exposure and the decrease of urinary excretion.
Yoo-Seong Jeong, Anusha Balla, Kwang-Hoon Chun, Suk-Jae Chung, Han-Joo Maeng   +4 more
doaj   +1 more source

Cimetidine Does Not Inhibit 5-Aminolevulinic Acid Synthase or Heme Oxygenase Activity: Implications for Treatment of Acute Intermittent Porphyria and Erythropoietic Protoporphyria

Biomolecules, 2023
Acute intermittent porphyria (AIP) is characterized by acute neurovisceral attacks that are precipitated by the induction of hepatic 5-aminolevulinic acid synthase 1 (ALAS1).
Makiko Yasuda, Sangmi Lee, Lin Gan, Hector A. Bergonia, Robert J. Desnick, John D. Phillips   +5 more
doaj   +1 more source

Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine

Pharmaceutics, 2018
A sensitive and simple chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to evaluate memantine in rat plasma. Memantine and propranolol (internal standard) in rat plasma was extracted using a methanol precipitation method.
Young A. Choi, Im-Sook Song, Min-Koo Choi   +2 more
doaj   +1 more source

Cimetidine hepatitis

Gastroenterology, 1979
This case of an adult with cimetidine-induced hepatitis is presented. An etiologic role for the drug was strongly suggested when the patient developed transient hepatic dysfunction after two reexposures to cimetidine, which reverted promptly on withdrawal of the drug.
J P, Villeneuve, H A, Warner
openaire   +4 more sources

Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice

International Journal of Hepatology, 2020
Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil ...
Lubna Danish, Riffat Siddiq, Sarwat Jahan, Mehwish Taneez, Manzoor Khan, Marva Sandhu   +5 more
doaj   +1 more source

Acute tubulointerstitial nephritis associated with antineutrophil cytoplasmic antibody following cimetidine treatment: a case report

BMC Nephrology, 2021
Background Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis usually induces rapidly progressive glomerulonephritis, including pauci-immune necrotizing crescentic glomerulonephritis.
Keita Morimoto, Go Kanzaki, Takahito Niikura, Kentaro Koike, Nanae Matsuo, Yukio Maruyama, Nobuo Tsuboi, Takashi Yokoo   +7 more
doaj   +1 more source