Results 21 to 30 of about 12,244 (184)
Cells, 2022 Despite potent anticancer activity, the clinical utilization of cisplatin is limited due to nephrotoxicity. As Organic Cation Transporter 2 (OCT2) has been shown to be one of the key transporters involved in the uptake of cisplatin into renal proximal ...
Hardik Mody +3 more
doaj +1 more source
Zagazig Journal of Pharmaceutical Sciences, 1993 The effects of captopril (1 mg/kg), cimetidine (25 mg/kg), and their combination on the arterial blood pressure, heart rate, ECG and the calculated double product of anaesthetized normotensive rats were investigated.
Salah Ghareib +2 more
doaj +1 more source
Zagazig Journal of Pharmaceutical Sciences, 1993 The effects of a single dose of nifedipine (5 mg/Kg, 1.P.) alone, Cimetidine (25 mg/Kg, I.P. for 7 days) alone or their combination on the arterial blood presure, heart rate, the calculated double product, and electrocardiogram (ECG) in anaesthetized ...
Hassan El-Fayoumi +2 more
doaj +1 more source
The Landscape of Biomarkers in ICU‐Associated AKI: From Protein Markers to Cell‐Free Nucleic Acids
Journal of Clinical Laboratory Analysis, EarlyView.Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Qi Zhu +10 more
wiley +1 more source
Animal Models and Experimental Medicine, 2019 Background The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself. Treatment or management therapy is often expensive. This study investigated the effects of acetone extract of a
Ngozi Joy Onwuemene +2 more
doaj +1 more source
Andrology, EarlyView.ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus +6 more
wiley +1 more source
Interactions of Human- and Rat-Organic Anion Transporters With Pravastatin and Cimetidine
Journal of Pharmacological Sciences, 2004 We have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1
Suparat Khamdang +8 more
doaj +1 more source
Methaemoglobinaemia: From pathophysiology to contemporary clinical management
British Journal of Haematology, EarlyView.Summary Methaemoglobin (MetHb) is an oxidised form of haemoglobin (Hb) unable to bind oxygen. Raised levels of MetHb reduce the blood's oxygen‐carrying capacity, causing potentially severe hypoxaemia and possible death. The condition arises from three main pathologies: mutations in globin genes causing Haemoglobin‐M, inherited deficiency of the enzyme ...
Alexander J. Twine, David C. Rees
wiley +1 more source
Journal of Pharmacological Sciences, 2003 The effects of cimetidine on rat adjuvant arthritis (AA) and rat osteoclast differentiation were studied. For the in vivo experiments, AA was induced by injections of Mycobacterium tuberculosis H37RA either subcutaneously into the base of the tail or ...
Katsunori Yamaura +4 more
doaj +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background Erythropoietic protoporphyria (EPP) is a rare genetic disorder characterized by severe phototoxic reactions that occur within minutes of light exposure. In clinical studies, afamelanotide has been shown to prolong pain‐free sun exposure, improve quality of life, and reduce the frequency and severity of phototoxic reactions ...
Magdalena Seidl‐Philipp +9 more
wiley +1 more source