Results 31 to 40 of about 12,244 (184)
Treatments for Molluscum contagiosum: A systematic review
Summary Molluscum contagiosum (MC) is a viral skin infection that poses significant physical and psychosocial burdens, particularly in pediatric and immunocompromised populations. Despite the availability of various treatment options, comparative efficacy and safety data remain limited.
Ou Jia (Emilie) Wang +3 more
wiley +1 more source
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup +2 more
wiley +1 more source
Cimetidine as an Effective Corrosion Inhibitor for Mild Steel in Hydrochloric Acid
The performance of Cimetidine (2-cyano- 1-methyl- 3-(2-[(5-methyl- 1H-imidazol- 4- yl)methylthio]ethyl)guanidine) as corrosion inhibitor for mild steel in 1 M HCl was thoroughly investigated by weight loss and electrochemical methods.
Ambrish Singh +5 more
doaj +1 more source
Fluorinated aminopiperidones, designed as non‐glutarimide thalidomide analogs, were synthesized with full regio‐ and stereocontrol. The C*–CF3 used as carbonyl surrogate improved solubility and membrane interactions while abolishing cereblon binding.
Boštjan Adamlje +11 more
wiley +1 more source
Response to cimetidine in a 1-year-old child with PFAPA syndrome
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is characterized by periodic febrile attacks recurring regularly every 2 to 8 weeks.
Kazuto Taniguchi +4 more
doaj +1 more source
Abstract INTRODUCTION Neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), limbic‐predominant age‐related TDP‐43 encephalopathy (LATE), and Alzheimer's disease (AD) are associated with TAR DNA‐binding protein 43 (TDP‐43) pathology.
Chunfang A. Xia +10 more
wiley +1 more source
Optimal Weighted Tests for Replication Studies and the ‘Two‐Trials Rule’ With Multiple Hypotheses
ABSTRACT Replication studies for scientific research are an important part of ensuring the reliability and integrity of experimental findings. In the context of clinical trials, the concept of replication has been formalized by the “two‐trials” rule, where two pivotal studies are required to show positive results before a drug can be approved.
David S. Robertson, Thomas Jaki
wiley +1 more source
Protective assessment of cimetidine against cyclophosphamide-induced kidney injury
Background: Nephrotoxicity is one of the frequent toxicities observed with cyclophosphamide (CP) use which may involve oxidative stress. Cimetidine is an antihistamine with anti-oxidative stress activity.
Elias Adikwu , Bonsome Bokolo
doaj +1 more source
ABSTRACT Background Functional dyspepsia (FD) is characterised by postprandial fullness, early satiation, epigastric pain, or burning without structural abnormalities on upper endoscopy. Proton pump inhibitors (PPIs) are the preferred first‐line therapy.
Scheepers Janne +4 more
wiley +1 more source
Erythropoietic protoporphyria: case reports for clinical and therapeutic hints
Background Erythropoietic protoporphyria is a rare disorder which represents an important health problem in children, causing painful photosensitivity. Little is known on the correlation between genetic profile and clinical manifestations.
Cristina Tumminelli +8 more
doaj +1 more source

