Results 21 to 30 of about 24,926 (162)
Ascorbic acid prevents cimetidine-induced decrease of serum hydrocortisone concentrations [PDF]
, 1990 A blind, parallel, prospective, clinical study was conducted to investigate the effect of ascorbic acid on human serum hydrocortisone concentrations which were decreased by the administration of cimetidine.
Boidin, M.P. (Marinus Pieter) +2 more
core +1 more source
Gastroenterology, 1979 This case of an adult with cimetidine-induced hepatitis is presented. An etiologic role for the drug was strongly suggested when the patient developed transient hepatic dysfunction after two reexposures to cimetidine, which reverted promptly on withdrawal of the drug.
J P, Villeneuve, H A, Warner
openaire +4 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano +8 more
wiley +1 more source
The Journal of Clinical Pharmacology, EarlyView.Abstract Belumosudil is an oral selective rho‐associated coiled‐coil containing protein kinase 2 inhibitor, approved as a treatment for chronic graft‐versus‐host disease. Prior clinical studies demonstrated that coadministration with strong CYP3A4 inducers or proton pump inhibitors requires dose modification of belumosudil.
Olivier Schueller +4 more
wiley +1 more source
Indometh acin-antihistamine combination for gastric ulceration control [PDF]
, 1980 An anti-inflammatory and analgesic composition containing indomethacin and an H2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin was developed.
Brown, P. A., Vernikos, J.
core +1 more source
Pharmacological effects of aqueous–ethanolic extract of Hibiscus rosasinensis on volume and acidity of stimulated gastric secretion [PDF]
, 2011 ObjectiveTo explore the effects of extract of Hibiscus rosasinensis (H. rosasinensis) on the volume, free and total acidity of gastric secretion induced by carbachol.MethodsAnimals were kept on fasting for 48 h, then the pylorus of each animal was ...
Choudhury, Avijit +3 more
core +1 more source
Transport of six tyrosine kinase inhibitors: active or passive ? [PDF]
, 1995 Transport of erlotinib, gefitinib, sorafenib, sunitinib, dasatinib and crizotinib can be active or passive, which was studied by measuring uptake at low (4 °C; passive) and normal temperature (37 °C; active and passive) and by the use of specific organic
J. Honeywell, Richard +3 more
core +9 more sources
The Journal of Clinical Pharmacology, EarlyView.Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules +4 more
wiley +1 more source
Mortality study of 18 000 patients treated with omeprazole. [PDF]
, 2002 Background: The long term safety of potent gastric acid suppressive therapy has yet to be established. Method: General practice record review at a median interval of 26 months followed by retrieval of details of all deaths within four years using the ...
Bateman, D.N. +9 more
core
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu +12 more
wiley +1 more source