Results 31 to 40 of about 24,926 (162)

Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression [PDF]

, 2008
Background Cimetidine, a histamine type-2 receptor antagonist, has been reported to inhibit the growth of glandular tumors such as colorectal cancer, however the mechanism of action underlying this effect is unknown.
A Smahi, AR Sasson, C Burtin, CM França, CM Mooy, CP Siegers, CS Simpson, D Lapenna, E Kimura, F Lefranc, GM Edelman, H Seki, H Seki, H Tønnesen, Hideaki Sakashita, JA Hutcheson, JA Lawson, JF Hansbrough, JL Reynolds, JW Freston, K Kobayashi, K Shirasuna, K Tozawa, Kaoru Kusama, LA Krushel, M Fukuda, M Fukuda, M Fukuda, M Karin, M Karin, Masakatsu Fukuda, MS Rodriguez, PA Baeuerle, Q Deveraux, Q Li, R Gandour-Edwards, RZ Orlowski, TA Hazinski, WJ Adams, WJ Adams, Y Ohmori   +40 more
core   +3 more sources

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Anticholinergic burden quantified using the Japanese risk scale as a predictor of frailty and sarcopenia among community‐dwelling older adults: A 9‐year Kashiwa cohort study

Geriatrics &Gerontology International, Volume 25, Issue 4, Page 520-527, April 2025.
Anticholinergic burden, quantified using the Japanese Anticholinergic Drug Risk Scale, may be a predictor of frailty and sarcopenia in community‐dwelling older adults. Effective evaluation and management of anticholinergic burden using the Japanese Anticholinergic Drug Risk Scale are crucial for promoting healthy aging and mitigating adverse health ...
Tomoki Tanaka, Masahiro Akishita, Taro Kojima, Bo‐Kyung Son, Katsuya Iijima   +4 more
wiley   +1 more source

Indomethacin-antihistamine combination for gastric ulceration control [PDF]

, 1981
An anti-inflammatory and analgesic composition containing indomethacin and an H sub 1 or an H sub 2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin is described.
Brown, P. A., Danellis, J. V.
core   +1 more source

Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008 [PDF]

, 2012
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%).
A Grolla, A MacNeil, A Tuffs, AJ Georges, AM Casillas, B Jeffs, B Le Guenno, Benjamin Jeffs, BS Hewlett, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DH Smith, DL Heymann, E Mupere, ED Johnson, EM Leroy, EM Leroy, Esther Sterk, GA Martini, GA Martini, JL Conrad, Joseph Wamala, JS Gear, JS Towner, Julius Lutwama, K Kibadi, K Mupapa, K Mupapa, KJ Davis, M Borchert, M Bray, M Bray, MA Bwaka, Malcolm Gracie Semple, Maria D. Van Kerkhove, Matthias Borchert, ME Miranda, Michel Van Herp, MJ Bonnet, Natasha Howard, NK Jaax, P Formenty, P Formenty, P Francesconi, P Roddy, P Roddy, Paul Roddy, PE Rollin, Pedro Pablo Palma, PH Sureau, R Colebunders, R Ndambi, R Siegert, RC Baron, Robert Colebunders, RT Emond, S Becker, SF Dowell, SP Fisher-Hoch, SR Zaki, TH Roels, U Stroher, Y Kalongi, Zabulon Yoti   +66 more
core   +3 more sources

From Retention Time to Functional Group Assignment: A Chemical Database‐Driven Approach for High‐Resolution Mass Data of Marine Dissolved Organic Matter

Rapid Communications in Mass Spectrometry, Volume 39, Issue 13, 15 July 2025.
ABSTRACT Rationale The high chemodiversity of marine dissolved organic matter (DOM) has challenged identification of singular DOM components. To infer chemical structure features of DOM with accurately determined molecular formulas, we assessed if empirically determined elution properties of stoichiometrically identical isomers obtained from a chemical
Fabian Moye, Marlo Bareth, Boris P. Koch, Jan Tebben, Tilmann Harder   +4 more
wiley   +1 more source

NF-kB overexpression and decreased immunoexpression of AR in the muscular layer is related to structural damages and apoptosis in cimetidine-treated rat vas deferens [PDF]

, 2013
Background: Cimetidine, histamine H-2 receptors antagonist, has caused adverse effects on the male hormones and reproductive tract due to its antiandrogenic effect.
Beltrame, Flavia L., Caneguim, Breno H., Cerri, Paulo S., Koshimizu, Juliana Y., Pizzol, Jose P. de, Sasso-Cerri, Estela   +5 more
core   +3 more sources

Prospective, double-blind, placebo-controlled randomized trial of cimetidine in gastric cancer [PDF]

, 1999
Cimetidine is thought to inhibit suppressor T-lymphocyte function and preliminary evidence from a randomized trial indicated that it might prolong survival for patients with operable and inoperable gastric cancer.
Burton, A, Dunn, J A, Fielding, J W L, Hallissey, M T, Kerr, D J, Langman, M J S, Whiting, J L   +6 more
core   +2 more sources

Regional cerebral blood flow in a patient with restless legs syndrome exhibiting pramipexole‐induced hypersexuality

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 2, June 2025.
Abstract Background Impulse control disorders (ICDs), including hypersexuality, are associated with adverse effects of dopamine agonists, such as pramipexole, particularly in the treatment of Parkinson's disease and restless legs syndrome (RLS). The underlying mechanisms remain unclear in ICDs in patients with RLS, and no neuroimaging studies have ...
Toshiki Obata, Ryota Kobayashi, Toshinori Shirata, Keisuke Noto, Yasuhiro Sugai, Gaku Aboshi, Masafumi Kanoto, Akihito Suzuki   +7 more
wiley   +1 more source

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter, Kessler, C., Krause, Klaus-Henning, Reuther, R.   +3 more
core   +1 more source