Results 61 to 70 of about 25,606 (192)

Cimetidine Attenuates Therapeutic Effect of Anti-PD-1 and Anti-PD-L1 and Modulates Tumor Microenvironment in Colon Cancer

Biomedicines
Histamine modulates immunity by binding to histamine receptor 2 (H2R). Cimetidine, an H2R antagonist that inhibits gastric acid secretion and treats gastrointestinal ulcers, interferes with histamine-mediated immunomodulation and may have anticancer ...
Feng-Chi Kuo, Jerry Cheng-Yen Lai, Hui-Ru Shieh, Wan-Zu Liou, Ming-Jong Bair, Yu-Jen Chen   +5 more
doaj   +1 more source

Increased Glomerular Filtration Rate in Early Stage of Balkan Endemic Nephropathy

Medicina, 2019
Background: A previous study indicated that Balkan endemic nephropathy (BEN) patients in the early stage of the disease had significantly higher creatinine clearance (Ccr) than healthy persons.
Ljubica Djukanović, Višnja Ležaić, Danica Bukvić, Dušan Mirković, Ivko Marić   +4 more
doaj   +1 more source

The role of endocardial endothelium in the effect of histamine on myocardial contractions of histamine H1 and H2 receptor blockade [PDF]

Praxis Medica, 2016
Endocardial endothelium (EE) is a barrier which controls the passage of macromolecules and fluids between the blood and the adjacent miocardial interstitium. At the same time it is the place of synthesis of numerous endothelial mediators. Histamine as an
Smiljić Sonja, Parlić Dragica, Milanović Zvezdan, Nestorović Vojkan, Pavlović Mirjana   +4 more
doaj   +1 more source

Primary and Secondary Grzybowski’s Generalized Eruptive Keratoacanthoma: A New Perspective on Management, Clinical Features, and Prognosis

International Journal of Dermatology, Volume 65, Issue 3, Page 456-463, March 2026.
ABSTRACT Grzybowski's generalized eruptive keratoacanthoma (GEKA) is a rare variant of keratoacanthomas, characterized by hundreds to thousands of lesions, accompanied by pruritus, mucosal involvement, and comorbidities. Our aim was to analyze the clinical presentation, associated comorbidities, treatment strategies, and outcomes of GEKA.
Nicholas Florin Kormos, Carina Maria Petrenciu, Alin Stefan Vizitiu, Raluca Ghețe, Umer Nadir, Adrian Lucian Baican, Stanislav N. Tolkachjov   +6 more
wiley   +1 more source

Penile warts: an update on their evaluation and management

Drugs in Context, 2018
Background: Penile warts are the most common sexually transmitted disease in males. Clinicians should be familiar with the proper evaluation and management of this common condition.
Alexander KC Leung, Benjamin Barankin, Kin Fon Leong, Kam Lun Hon   +3 more
doaj   +1 more source

Mortality study of 18 000 patients treated with omeprazole. [PDF]

, 2002
Background: The long term safety of potent gastric acid suppressive therapy has yet to be established. Method: General practice record review at a median interval of 26 months followed by retrieval of details of all deaths within four years using the ...
Bateman, D.N., Colin-Jones, D., Hartz, S., Langman, M., Logan, R.F., Mant, J.W.F., Murphy, M, Paterson, K.R., Rowsell, R., Thomes, S.   +9 more
core  

Afferent signalling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine [PDF]

, 2009
Background Lafutidine is a histamine H2 receptor antagonist, the gastroprotective effect of which is related to its antisecretory activity and its ability to activate a sensory neuron-dependent mechanism of defence. The present study investigated whether
Martin E Edelsbrunner, Motoko Nakano, Peter Holzer, R Schuligoi, M Danzer, K Lamb, M Jocic, S Onodera, S Onodera, H Mimaki, K Fukushima, P Holzer, P Holzer, RE Kirk, WL Hays, R Munglani, KJ Kovács, M Okayama, JH Walsh, IT Lippe, P Holzer, FD Manela, P Holzer, K Nishihara, T Shimatani, N Harada   +25 more
core   +2 more sources

Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 832-853, March 2026.
ABSTRACT Background Functional dyspepsia (FD) is a common gastrointestinal disorder that significantly impacts patients' quality of life. Over a decade ago, the Asian Neurogastroenterology and Motility Association (ANMA) and the Asian Pacific Association of Gastroenterology (APAGE) jointly developed the first Asian consensus report on FD.
Sanjiv Mahadeva, Kewin Tien Ho Siah, Uday C. Ghoshal, Hidekazu Suzuki, Yeong Yeh Lee, Kee Huat Chuah, Vincent Chung, Linda Zhong, Benjamin Wei‐Rong Tay, Ban Hong Ang, Ram Prasad Sinnanaidu, Tao Bai, Tadayuki Oshima, Tanisa Patcharatrakul, Sanjeev Sachdeva, Ping‐Huei Tseng, Jinsong Liu, Yinglian Xiao, Ratha‐Korn Vilaichone, Joon Seong Lee, Jung‐Hwan Oh, Ari Fahrial Syam, Ching Liang Lu, Tiing Leong Ang, In‐Kyung Sung, Xiao‐Hua Hou, Kentaro Sugano, Justin Wu, Hiroto Miwa   +28 more
wiley   +1 more source

Effect of cimetidine on cyclophosphamide-induced liver toxicity in albino rats

Asian Journal of Medical Sciences, 2018
Background: The clinical use of cyclophosphamide (CP) has been characterised by liver toxicity. Aims and Objectives: This research assessed the effect of cimetidine against CP-induced liver toxicity in a rat model. Material and Methods: Forty eight
Elias Adikwu , Bonsome Bokolo
doaj   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source