Results 71 to 80 of about 25,606 (192)

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
Chewable softgels are a patient‐preferred alternative to conventional oral forms, offering pleasant taste, fast onset, and suitability for children or patients with swallowing difficulties. However, they present relevant challenges in their formulation: the shell must balance chewability, machinability, and stability, while the fill must mask the ...
Almudena Naharros‐Molinero, María Ángela Caballo‐González, Francisco Javier de la Mata, Sandra García‐Gallego   +3 more
wiley   +1 more source

Thermoanalytical studies of cimetidine and complexes with Mn(II) Co(II) and Ni(II)

Semina: Ciências Exatas e Tecnológicas, 2014
Cimetidine is an important hydrogen histamine receptor and can coordinate metal ions in blood plasma. The stability of cimetidine and its complexes with Mn(II), Co(II) and Ni(II) was evaluated by studies of thermogravimetry (TG) and differential thermal ...
Ana Carolina Mendes Hacke, Fernanda Moreira, Egon Schnitzler, Neiva Deliberali Rosso   +3 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Cimetidine (H2 histamine antagonist), Fexofenadine (H1 histamine antagonist), and Zinc sulphate in the treatment of erythropoietic protoporphyria

Photodiagnosis and Photodynamic Therapy
Background: Erythropoietic protoporphyria (EPP) patients are deficient in the ferrochelatase enzyme which converts protoporphyrin IX (PpIX) into heme, causing PpIX to accumulate in mature erythrocytes and skin.
Hans Christian Wulf, Peter A. Philipsen, Catharina M. Lerche   +2 more
doaj   +1 more source

Vitamin B12 and Reproductive Health: Clinical Insights, Emerging Mechanistic Understanding, and Nutritional Aspects

Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.
ABSTRACT Epidemiological data from assisted reproductive technologies (ART) link vitamin B12 (VitB12) deficiency to shorter gestation, low birth weight, and reduced live birth rates. VitB12 also plays a critical role in fertility for both sexes by supporting gamete quality.
Aimee Rachel Mathew, Erisa Selita, Chiara Regano, Claudia Bianco, Veronica Corsetti, Virve Cavallucci, Sandra Moreno, Ada Maria Tata, Marco Fidaleo   +8 more
wiley   +1 more source

Roxatidine- and Cimetidine-Induced Angiogenesis Inhibition Suppresses Growth of Colon Cancer Implants in Syngeneic Mice

Journal of Pharmacological Sciences, 2003
: Cimetidine is known to suppress the growth of several tumors, including gastrointestinal cancer, in humans and animals. Nonetheless, whether other histamine H2-receptor antagonists exert such tumor suppressive effects remains unclear.
Kazuyoshi Tomita, Kazuki Izumi, Susumu Okabe   +2 more
doaj   +1 more source

Preclinical Modeling and Simulation to Explore the Tissue/Plasma Exposure and Pharmacodynamic Effect of Vildagliptin in Diabetes Treatment

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Vildagliptin (VDG) is a dipeptidyl‐peptidase‐4 (DPP‐4) inhibitor used for type 2 diabetes (T2DM) treatment. Viewing to improve VDG treatment, a population pharmacokinetic (popPK) model was built to describe drug plasma, free liver and muscle concentrations determined by microdialysis in healthy and diabetic animals following 50 mg/kg i.v ...
Bruna Bernar Dias, Laura Ben Olivo, Bibiana Verlindo de Araújo   +2 more
wiley   +1 more source

Recurrence of Acute Duodenal Ulcer

Canadian Journal of Gastroenterology, 1994
Nizatidine, 300 mg once nightly, was compared with cimetidine, 800 mg once nightly, for treatment of 212 adult out-patients with acute duodenal ulcers in an eight-week randomized, double-blind, multicentre trial.
RJ Bailey, IG Morrison-Cleator, A Farley, A Archambault, M Oravec, RS Davies, LR Sutherland, M Grace, The Nizatidine Multicentre Duodenal Ulcer Study Group   +8 more
doaj   +1 more source

Preparation and Removal Properties of Cimetidine from Aqueous Solution by Waste Bricks Incorporated with Different Iron Oxides

Applied Sciences, 2019
In this study, to investigate the elimination of micropollutant from aqueous solutions by construction waste, waste red brick (WRB) with and without incorporated of iron species (goethite and hematite) were prepared by a simple method.
Ziyang Zhang, Fangyuan Liu, Chunya Xu, Hongrui Chen, Chaohong Tan, Xiaoran Zhang   +5 more
doaj   +1 more source