Results 41 to 50 of about 30,773 (318)

Quantitative determination of major alkaloids in Cinchona bark by Supercritical Fluid Chromatography

open access: yesJournal of Chromatography A, 2018
Chinoline alkaloids found in Cinchona bark still play an important role in medicine, for example as anti-malarial and antiarrhythmic drugs. For the first time Supercritical Fluid Chromatography has been utilized for their separation.
Adele Murauer, M. Ganzera
semanticscholar   +1 more source

In Silico Screening and Designing Synthesis of Cinchona Alkaloids Derivatives as Potential Anticancer [PDF]

open access: yes, 2017
P-glycoprotein (P-gp) resistance in cancer cells decreases intracellular accumulation of various anticancer drugs. This multidrug resistance (MDR) protein can be modulated by a number of non-cytotoxic drugs.
Hanafi, M. (Muhammad)   +4 more
core   +2 more sources

Mechanism and Origins of Stereoselectivity in the Cinchona Thiourea- and Squaramide-Catalyzed Asymmetric Michael Addition of Nitroalkanes to Enones.

open access: yesJournal of Organic Chemistry, 2017
We report density functional theory calculations that examine the mechanism and origins of stereoselectivity of Soós' landmark discovery from 2005 that cinchona thioureas catalyze the asymmetric Michael addition of nitroalkanes to enones.
Matthew N. Grayson
semanticscholar   +1 more source

Localization of Alkaloid and Other Secondary Metabolites in Cinchona ledgeriana Moens: Anatomical and Histochemical Studies on Fresh Tissues and Cultured Cells

open access: yesHayati Journal of Biosciences, 2020
Cinchona ledgeriana produces several secondary metabolites. The main quinoline alkaloid, quinine that is widely used as an antimalarial drug, is most commonly extracted from the bark of Cinchona, and its leaves contain several other metabolites.
Dian Rahma Pratiwi   +2 more
doaj   +1 more source

Maladies des arbres à quinquina en Guinée française [PDF]

open access: yes, 1956
Chevaugeon Jean, Merny Georges. Maladies des Arbres à Quinquina en Guinée Française. In: Journal d'agriculture tropicale et de botanique appliquée, vol. 3, n°11, novembre 1956. pp.
Chevaugeon, Jean, Merny, Georges
core   +1 more source

Phylogeny Predicts the Quantity of Antimalarial Alkaloids within the Iconic Yellow Cinchona Bark (Rubiaceae: Cinchona calisaya)

open access: yesFrontiers in Plant Science, 2017
Considerable inter- and intraspecific variation with respect to the quantity and composition of plant natural products exists. The processes that drive this variation remain largely unknown.
Carla Maldonado   +7 more
semanticscholar   +1 more source

Metal Nanoparticles on Halloysite Applied in Stereoselective Hydrogenation of Tetrasubstituted Alkenes

open access: yesChemistry – A European Journal, EarlyView.
Composite materials based on metal nanoparticles supported on a naturally occurring nanotubular clay, halloysite (HAL), led to the diastereoselective hydrogenation of tetra‐substituted alkenes under relatively smooth conditions, mainly oxazolidinone‐based heterocycles.
Rosa Pich   +9 more
wiley   +1 more source

Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts

open access: yesBeilstein Journal of Organic Chemistry, 2016
Cinchona alkaloids with a free 6'-OH functionality are being increasingly used within asymmetric organocatalysis. This fascinating class of bifunctional catalyst offers a genuine alternative to the more commonly used thiourea systems and because of the ...
Laura A. Bryant   +2 more
doaj   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

open access: yesChemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini   +3 more
wiley   +1 more source

Cinchona Alkaloid-Squaramide Catalyzed Sulfa-Michael Addition Reaction: Mode of Bifunctional Activation and Origin of Stereoinduction.

open access: yesJournal of Organic Chemistry, 2017
The mechanism of the enantioselective sulfa-Michael addition reaction catalyzed by a cinchona alkaloid-squaramide bifunctional organocatalyst was studied using density functional theory (DFT). Four possible modes of dual activation mechanism via hydrogen
Jinlong Guo, M. W. Wong
semanticscholar   +1 more source

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