Comparison of CINtec PLUS cytology and cobas HPV test for triaging Canadian patients with LSIL cytology referred to colposcopy: A two-year prospective study. [PDF]
Cancer Biomark, 2022 OBJECTIVES & METHODS: CINtec PLUS and cobas HPV tests were compared for triaging patients referred to colposcopy with a history of LSIL cytology in a 2-year prospective study. Cervical specimens were tested once at enrollment, and test positivity rates determined.
Gilbert L +12 more
europepmc +3 more sources
CINtec PLUS: A Novel Alternative Screening Method for Detecting High-Risk Cervical Lesions in Romania. [PDF]
CureusIntroduction CINtec PLUS is a relatively recent method introduced in Romania for detecting cervical precancerous lesions. This technique utilizes simultaneous double immunostaining with p16 and Ki67 to identify potentially transformative human papillomaviruses (HPVs).
Camarasan OA +8 more
europepmc +3 more sources
Methylation-Specific Droplet Digital PCR: Testing a Novel Triage Tool for HrHPV-Positive Women in the Cervical Cancer Screening Program of Northern Portugal. [PDF]
MedComm (2020)MedComm, Volume 6, Issue 7, July 2025.
Salta S +9 more
europepmc +2 more sources
The importance of combined HPV and CINtec® PLUS genotyping testing for p16 in women with cervical squamous cell carcinoma. [PDF]
Rom J Morphol EmbryolImmunohistochemistry (IHC) for p16INK4A (p16) is a reliable surrogate test for the presence of a high-risk, potentially transformative human papillomavirus (HPV) infection in precursor and malignant lesions of the cervix. The purpose of this study was to evaluate changes in cervical cells caused by persistent HPV infection, by IHC (p16 protein) by ...
Voidăzan TS +3 more
europepmc +3 more sources
Diagnostic Accuracy of p16INK4a/Ki-67 Dual Immunostaining for Detection of High-Grade Cervical Intraepithelial Neoplasia in Women Involved in Cervical Cancer Screening in Georgia. [PDF]
Anal Cell Pathol (Amst), 2023 Background. Despite the widespread introduction of primary and secondary preventative measures, death rates for cervical cancer are still significantly high among females, especially in developing countries. Pap cytology and human papillomavirus‐based screening often lead to unnecessary additional testing. The aim of this study is to analyze diagnostic
Kakaliashvili-Dzagnidze S +2 more
europepmc +2 more sources
Clinical Utility of CINtec PLUS Triage in Equivocal Cervical Cytology and Human Papillomavirus Primary Screening [PDF]
American Journal of Clinical Pathology, 2018 While cervical cytology is accepted triage for human papillomavirus (HPV)-positive women, the efficiency of cervical screening could be improved by exploiting disease markers with higher specificity.CINtec PLUS triage alone and combined with HPV 16/18 genotyping was performed on ThinPrep samples from HPV-positive women.
Mary McMenamin +2 more
openaire +2 more sources
Combined HPV and CINtec PLUS testing for triaging cervical cancer screening in a Belgian cohort
Annals of Cytology and Pathology, 2023 Background: Cytological screening with Human Papillomavirus (HPV) triage for equivocal results has been the routine screening procedure for cervical cancer for years worldwide. The dual-marker stain p16/Ki67 (CINtec PLUS) has been shown to offer high sensitivity and specificity in the triage of women at risk of developing HPV-related precancerous ...
Cras, Louise +5 more
openaire +1 more source
Pathogens, 2021 Men who have sex with men (MSM) harbor the highest risk for anal carcinoma, mainly caused by Human Papillomavirus (HPV). The use of HPV-related biomarkers in the screening for this neoplasia is still debated. We assessed the association between high-risk
Francesca Rollo +5 more
doaj +1 more source
Diagnostics, 2021 Recently, cervical cancer rates elevation has been noted in women aged 20–39 years in regions with a very high human development index (HDI). The onset of cancer elevation rates is observed in the age range of 25–29 years, which should necessitate ...
Martyna Trzeszcz +12 more
doaj +1 more source
Negative margins and negative HPV tests after large loop excision of the transformation zone: A nationwide historical cohort study. [PDF]
Acta Obstet Gynecol ScandWomen aged 50 years and older treated with LLETZ face a higher risk of inadequate treatment. Moreover, our findings highlight the need for standardized reporting of missing follow‐up records to improve monitoring of quality indicators. Abstract Introduction Adequate treatment of cervical precancer, defined as negative margins and a negative HPV test ...
Knudsen AS +6 more
europepmc +2 more sources