Results 21 to 30 of about 429 (97)

The Accuracy of p16/Ki-67 and HPV Test in the Detection of CIN2/3 in Women Diagnosed with ASC-US or LSIL. [PDF]

PLoS ONE, 2015
The objective of this study was to compare the accuracies of double staining for p16/Ki-67 and the molecular test for high-risk HPV (hr-HPV) to identify high-grade cervical intraepithelial neoplasia (CIN2/CIN3) in women with cervical cytology of atypical
Júlio C Possati-Resende, José H T G Fregnani, Ligia M Kerr, Edmundo C Mauad, Adhemar Longatto-Filho, Cristovam Scapulatempo-Neto   +5 more
doaj   +1 more source

Time trends in prevalence of p16 positivity and combined HPV/p16 positivity in a large cohort of Danish vulvar cancer patients

International Journal of Cancer, Volume 152, Issue 11, Page 2424-2432, 1 June 2023., 2023
What's new? A subset of vulvar cancers is caused by high‐risk human papillomavirus (HPV), which primarily exerts its oncogenic effect through upregulation of tumor suppressor protein p16. How the proportion of HPV‐driven vulvar cancers has changed over time remains largely unexplored.
Christina Louise Rasmussen, Louise T. Thomsen, Louise Baandrup, Maria Benedicte Franzmann, Alexander K. Kjær, Lise Grupe Larsen, Else Mejlgaard Madsen, Nadia Margeth Villena Salinas, Doris Schledermann, Birgitte Hjelm Winberg, Dorthe Ørnskov, Marianne Waldstrøm, Susanne K. Kjær   +12 more
wiley   +1 more source

Clinical utility of p16/Ki67 dual‐stain cytology for detection of cervical intraepithelial neoplasia grade two or worse in women with a transformation zone type 3: A cross‐sectional study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 130, Issue 2, Page 202-209, January 2023., 2023
Abstract Objective To evaluate the clinical utility of p16/Ki67 dual‐stain (DS) compared with cytology for detecting cervical intraepithelial lesion grade two or worse (CIN2+) in women with a transformation zone type 3 (TZ3). Design Cross‐sectional study. Setting Colposcopy clinics in Central Denmark Region.
Line Winther Gustafson, Mette Tranberg, Pia Nørgaard Christensen, Rikke Brøndum, Nicolas Wentzensen, Megan A. Clarke, Berit Andersen, Lone Kjeld Petersen, Pinar Bor, Anne Hammer   +9 more
wiley   +1 more source

Implementation of p16/Ki67 dual stain cytology in a Danish routine screening laboratory: Importance of adequate training and experience

Cancer Medicine, 2020
Background Immunocytochemical staining with p16/Ki67 has been suggested as a promising triage biomarker in cervical cancer screening. As dual staining is a subjective method, proper training may be required to ensure safe implementation in routine ...
Anne Hammer, Line W. Gustafson, Pia N. Christensen, Rikke Brøndum, Berit Andersen, Rikke H. Andersen, Mette Tranberg   +6 more
doaj   +1 more source

Performance of p16/Ki67 immunostaining, HPV E6/E7 mRNA testing, and HPV DNA assay to detect high-grade cervical dysplasia in women with ASCUS

BMC Cancer, 2019
Background Atypical squamous cell of undetermined significance (ASCUS) is a common cervical cytological diagnosis. At present, HPV DNA assay is used to triage these patients, but its lower specificity brings a series of problems.
Yuanhang Zhu, Chenchen Ren, Li Yang, Xiaoan Zhang, Ling Liu, Zhaoxin Wang   +5 more
doaj   +1 more source

Evaluation of p16/Ki-67 dual staining compared with HPV genotyping in anal cytology with diagnosis of ASC-US for detection of high-grade anal intraepithelial lesions

Journal of Cytology, 2019
Introduction: Human Papillomavirus (HPV) infection is the main risk factor for anogenital cancer. The objective of this study was to compare p16/Ki-67 dual staining to HPV genotyping in anal cytology samples with an atypical squamous cell of undetermined
Maxime Pichon, Marie Joly, Frédérique Lebreton, Medhi Benchaïb, Yahia Mekki, Mojgan Devouassoux-Shisheboran   +5 more
doaj   +1 more source

p16/Ki-67 dual staining has a better accuracy than human papillomavirus (HPV) testing in women with abnormal cytology under 30 years old

Biomolecules & Biomedicine, 2019
Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has a low specificity for high-grade cervical lesions, especially in young women.
Laurențiu Pirtea, Cristina Secosan, Madalin Margan, Lavinia Moleriu, Oana Balint, Dorin Grigoras, Ioan Sas, Florin Horhat, Adelina Jianu, Răzvan Ilina   +9 more
doaj   +1 more source

Prognostic and diagnostic validity of p16/Ki-67, HPV E6/E7 mRNA, and HPV DNA in women with ASCUS: a follow-up study

Virology Journal, 2019
Background We evaluated the prognostic and diagnostic ability of p16/Ki-67 immunocytochemistry, HPV E6/E7 mRNA testing and HPV DNA assay in triaging ASCUS to find a way to manage cervical lesions more effectively. Methods We conducted a prospective study
Chenchen Ren, Yuanhang Zhu, Li Yang, Xiaoan Zhang, Ling Liu, Zhaoxin Wang, Dongyuan Jiang   +6 more
doaj   +1 more source

DNA‐Methylation for Risk‐Stratification of Women Without a Fully Visible Transformation Zone at Colposcopy: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the performance of DNA methylation markers for the detection of cervical precancer among screening‐positive older women without a fully visible transformation zone at colposcopy (TZ3). Design Cross‐sectional study. Setting Colposcopy clinics, Central Denmark Region, 2019–2021.
Karen Omann Binderup, Joachim Boers, Line Winther Gustafson, Berit Andersen, Lone Kjeld Petersen, Pinar Bor, Joost Gribnau, Wim G. V. Quint, Henk Van Den Munckhof, Mette Tranberg, Anne Hammer   +10 more
wiley   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source