Results 31 to 40 of about 920 (164)

Predictive biomarkers for regression in women undergoing active surveillance for cervical intraepithelial neoplasia grade 2: A prospective multicenter study in Italy. [PDF]

Int J Cancer
What's new? Cervical intraepithelial neoplasia grade 2 (CIN2) lesions can spontaneously regress, especially in women aged under 30. Better predictive biomarkers are needed to improve risk stratification for active surveillance. This prospective multicenter cohort study evaluated HPV genotyping, p16/ki67 expression, and FAM19A4/miR124‐2 methylation ...
Frayle H, Gori S, Pagan A, Soldà M, Romagnolo C, Insacco E, Laurino L, Matteucci M, Sordi G, Busato E, Zorzi M, Maggino T, Del Mistro A, CIN2 Study Working Group.   +13 more
europepmc   +2 more sources

Triaging borderline/mild dyskaryotic Pap cytology with p16/Ki-67 dual-stained cytology testing: Cross-sectional and longitudinal outcome study [PDF]

, 2014
Background: Women with borderline/mildly dyskaryotic (BMD) cytology smears are currently followed up with repeat testing at 6 and 18 months. The objective of this study is to analyse the cross-sectional and longitudinal performance of p16/Ki-67 dual ...
Balfoort-Van Der Meij, G.A.M.A. (G. A M A), Berkhof, J. (Johannes), Bleeker, M.C.G. (Maaike), Kemenade, F.J. (Folkert) van, Meijer, C.J.L.M. (Chris J. L.), Ridder, R. (Rogier) de, Rijkaart, D.C. (Dorien), Snijders, P.J.F. (Peter), Uijterwaal, M.H. (Margot), Witte, B.I. (Birgit)   +9 more
core   +2 more sources

MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia [PDF]

, 2018
OBJECTIVE: To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers ...
Bordi, G, Carico, E, Caserta, D, DE VITIS, C, DI PROPERZIO, M, Giglio, S, Lukic, A, Mancini, R.   +7 more
core   +1 more source

p16INK4a/Ki-67 dual stain cytology for cervical cancer screening in Thika district, Kenya [PDF]

, 2015
Background: The identification of suited early detection tests is one among the multiple requirements to reduce cervical cancer incidence in developing countries.
Boga, Hamadi, Mbithi, John, Muigai, Anne, Reuschenbach, Miriam, Schmidt, Dietmar, von Knebel-Doeberitz, Magnus, Wangari Ngugi, Caroline, Wanyoro, Karanja, Wanzala, Peter   +8 more
core   +1 more source

Experimental behavior of masonry wall-to-timber elements connections strengthened with injection anchors [PDF]

, 2014
Out-of-plane failure mechanisms observed in stone masonry buildings subjected to seismic action are often a direct result of poor connections between structural elements.
Algeri, Appleton, Bento, Brignola, Cook, Daniel V. Oliveira, Eligehausen, Frocht, Lin, Luís F. Ramos, Mascarenhas, Mendes, Milosevic, Oliveira, Parisi, Park, Paulo B. Lourenço, Pinho, Ramos, Silva, Susana Moreira, Tomaževič, Vasconcelos, Yi, Zamora   +24 more
core   +1 more source

Multicenter research into the quality of life of patients with advanced oropharyngeal carcinoma with long-term survival associated with human papilloma virus [PDF]

, 2017
The treatment of advanced-stage oropharyngeal squamous cell carcinoma may utilize various modes, including combining surgery with chemoradiotherapy (CTRT), or primary CTRT followed by rescue surgery.
Ausoni, Simonetta, Azzarello, Giuseppe, Baboci, Lorena, Bonazza, Deborah, Cocuzza, Salvatore, Costantini, Giulio, Da Mosto, Maria Cristina, Del Mistro, Annarosa, Di Mauro, Paola, Maiolino, Luigi, Politi, Doriano, Serra, Agostino, Spinato, Giacomo, Spinato, Roberto, Stellin, Marco, Tirelli, Gian Carlo, Tonoli, Giovanni, Zanconati, Fabrizio   +17 more
core   +1 more source

Diagnostic performance of p16/Ki-67 dual immunostaining at different number of positive cells in cervical smears in women referred for colposcopy [PDF]

, 2021
. The aim of the study was to evaluate the diagnostic accuracy of p16/Ki-67 dual immunostaining (p16/ Ki-67 DS) in cervical cytology and the number of positive p16/Ki-67 cells to diagnose high grade cervical intraepithelial neoplasia (CIN2+) in ...
Dovnik, Andraž, Ivanuš, Urška, Jerman, Tine, Repše-Fokter, Alenka, Salobir Gajšek, Uršula, Takač, Iztok, Šramek Zatler, Simona   +6 more
core   +2 more sources

RAD51C – a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC) [PDF]

, 2014
INTRODUCTION: Head and neck squamous cell carcinomas (HNSSCs) are one of the leading causes of cancer-associated death worldwide. Although certain behavioral risk factors are well recognized as tumor promoting, there is very little known about the ...
Baldus, Stephan E., Balz, Vera, Freund, Marcel, Hanenberg, Helmut, Pakropa, Petra, Scheckenbach, Kathrin, Schipper, Jörg, Schäfer, Karl-Ludwig, Sproll, Christoph, Wagenmann, Martin   +9 more
core   +1 more source

Performance of p16/Ki67 immunostaining, HPV E6/E7 mRNA testing, and HPV DNA assay to detect high-grade cervical dysplasia in women with ASCUS

BMC Cancer, 2019
Background Atypical squamous cell of undetermined significance (ASCUS) is a common cervical cytological diagnosis. At present, HPV DNA assay is used to triage these patients, but its lower specificity brings a series of problems.
Yuanhang Zhu, Chenchen Ren, Li Yang, Xiaoan Zhang, Ling Liu, Zhaoxin Wang   +5 more
doaj   +1 more source

Implementation of p16/Ki67 dual stain cytology in a Danish routine screening laboratory: Importance of adequate training and experience

Cancer Medicine, 2020
Background Immunocytochemical staining with p16/Ki67 has been suggested as a promising triage biomarker in cervical cancer screening. As dual staining is a subjective method, proper training may be required to ensure safe implementation in routine ...
Anne Hammer, Line W. Gustafson, Pia N. Christensen, Rikke Brøndum, Berit Andersen, Rikke H. Andersen, Mette Tranberg   +6 more
doaj   +1 more source