Results 31 to 40 of about 429 (97)

Predictive biomarkers for regression in women undergoing active surveillance for cervical intraepithelial neoplasia grade 2: A prospective multicenter study in Italy

International Journal of Cancer, Volume 158, Issue 3, Page 587-596, 1 February 2026.
What's new? Cervical intraepithelial neoplasia grade 2 (CIN2) lesions can spontaneously regress, especially in women aged under 30. Better predictive biomarkers are needed to improve risk stratification for active surveillance. This prospective multicenter cohort study evaluated HPV genotyping, p16/ki67 expression, and FAM19A4/miR124‐2 methylation ...
Helena Frayle, Silvia Gori, Alessio Pagan, Marika Soldà, Cesare Romagnolo, Egle Insacco, Licia Laurino, Mario Matteucci, Giuseppe Sordi, Enrico Busato, Manuel Zorzi, Tiziano Maggino, Annarosa Del Mistro, CIN2 Study Working Group, Annarosa Del Mistro, Helena Frayle, Silvia Gori, Rossana Trevisan, Alessio Pagan, Justyna Wojciechowska, Enrico Busato, Tiziano Maggino, Marika Soldà, Cesare Romagnolo, Licia Laurino, Pamela Zambenedetti, Egle Insacco, Mario Matteucci, Maria Teresa Gervasi, Giuseppe Sordi, Marco Torrazzina, Manuel Zorzi, Daria Minucci   +32 more
wiley   +1 more source

CURRENT APPROACHES FOR HPV-ASSOCIATED CIN

Мать и дитя в Кузбассе, 2020
The aim of the study was to determine the frequency of expression of р16/Ki-67 in the cervical epithelium of patients with HPV-associated CIN of various degrees according to immunocytochemical studies in comparison with patients without cervical ...
Татьяна Владимировна Клинышкова, Ольга Николаевна Миронова   +1 more
doaj  

Prognostic impact of p16 and high‐risk HPV DNA in ~1300 patients with vulvar cancer

International Journal of Cancer, Volume 157, Issue 7, Page 1354-1362, 1 October 2025.
What's New? Vulvar cancer (VSCC) is rare, and little is known about early prognostic factors that could contribute to an individualized treatment plan. About 30%–40% of VSCCs are associated with human papillomavirus (HPV). Here, the authors investigated the prognostic influence of p16 status in VSCC in a large cohort of 1300 patients.
Susanne K. Kjær, Kirsten Frederiksen, Christina L. Rasmussen, Louise T. Thomsen, Else M. Madsen, Maria B. Franzmann, Alexander K. Kjær, Lise G. Larsen, Nadia V. Salinas, Doris Schledermann, Birgitte H. Winberg, Pernille T. Jensen, Dorthe Ørnskov, Marianne Waldstrøm, Louise Baandrup   +14 more
wiley   +1 more source

Do Science and Technology Parks Work as Drivers of Firm Innovation? Empirical Evidence From Portugal

Creativity and Innovation Management, Volume 34, Issue 3, Page 721-739, September 2025.
ABSTRACT Science and technology parks were conceived to promote firm performance and innovation, and they have become increasingly important in local and regional development policies. However, there are few empirical studies on their effectiveness as drivers of firm innovation, and existing studies have also reported mixed results, which could be due ...
Júlio Paulo da Silva Martins, María Jesús Rodríguez‐Gulías, Raul Rios‐Rodríguez, David Rodeiro‐Pazos   +3 more
wiley   +1 more source

Optimizing Prognostic Assessment in High‐Risk Head and Neck Squamous Cell Carcinomas: The Impact of Tumor Budding and a Novel Histomorphological Scoring System

Cancer Medicine, Volume 14, Issue 4, February 2025.
ABSTRACT Background Head and neck squamous cell carcinomas (HNSCC) pose significant clinical challenges, particularly in high‐risk cases with positive lymph node status. Current prognostic biomarkers are often costly and methodologically demanding. In this regard, histomorphological biomarkers such as tumor buds (TB) and poorly differentiated clusters (
Moritz Knebel, Jan Philipp Kühn, Sandrina Körner, Felix Braun, Lukas Brust, Silke Wemmert, Sigrun Smola, Martin Ertz, Mathias Wagner, Bernhard Schick, Luc G. T. Morris, Maximilian Linxweiler, Gilbert Georg Klamminger   +12 more
wiley   +1 more source

High rate of persistent HPV detection after diagnostic cervical excision in older screen‐positive women

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 2, Page 342-349, February 2025.
Among older women monitored for 2.9 years after a diagnostic cervical excision, 70% tested negative for HPV. Consequently, 30% continued to test positive and remained in follow‐up. The optimal surveillance frequency and methods for these women remain uncertain.
Line Winther Gustafson, Louise Krog, Bayan Sardini, Mette Tranberg, Lone Kjeld Petersen, Berit Andersen, Pinar Bor, Anne Hammer   +7 more
wiley   +1 more source

Cost‐effectiveness analysis of alternative screening strategies for the detection of cervical cancer among women in rural areas of Western Kenya

International Journal of Cancer, Volume 155, Issue 7, Page 1257-1267, 1 October 2024.
What's new? In its updated screening recommendations for cervical cancer, the World Health Organization has urged existing programs to use visual inspection with acetic acid (VIA) as a primary screening tool to transition to human papillomavirus (HPV) DNA testing.
Christopher Lobin, Elkanah Omenge Orang'o, Edwin Were, Kapten Muthoka, Kavita Singh, Manuela De Allegri, Konrad Obermann, Magnus von Knebel Doeberitz, Hermann Bussmann   +8 more
wiley   +1 more source

p16INK4a and Ki-67 immunostaining - an alternative to rescreening of cervical samples with normal cytology and positive HPV test

Bioingeniøren, 2015
Background: Double immunostaining with CINtec® PLUS can be used to detect the proteins p16INK4a and Ki-67 in cytological cervix preparations. Detection of both proteins in the same cell is an indication of deregulated cell cycle and possible precancerous
Ann-Kristin Kolås Granberg, Randi B. Dannemark, Marte Halstadtrø, Maj Liv Eide   +3 more
doaj  

Dual Sec62/Ki67 immunocytochemistry of liquid‐based cytological preparations represents a highly valid biomarker for non‐invasive detection of head and neck squamous cell carcinomas

Cytopathology, Volume 35, Issue 1, Page 113-121, January 2024.
Simultaneous immunocytochemical detection of Sec62/Ki67 by LBC represents a highly valid and easy‐to‐use tool for non‐invasive detection of head and neck squamous cell carcinomas. This novel technique may help avoid incisional biopsies and reduce the frequency with which general anaesthesia is used in diagnostic procedures in patients with suspicious ...
Jan Philipp Kühn, Stefanie Speicher, Barbara Linxweiler, Sandrina Körner, Hugo Rimbach, Mathias Wagner, Erich Franz Solomayer, Bernhard Schick, Maximilian Linxweiler   +8 more
wiley   +1 more source

Estandarización de la doble biomarcación inmunocitoquímica P16/KI-67 en citología convencional para la detección de lesión intraepitelial escamosa de alto grado del cuello uterino

Revista Ciencias Biomédicas
Introducción: el ensayo inmunocitoquímico p16/Ki-67 revela la expresión simultánea de estos dos biomarcadores que aparece sólo durante la transformación neoplásica y aumenta el rendimiento de la citología cervical para detectar carcinoma o lesión ...
Ines Benedetti Padron, Alejandra Pineda Castilla, Lía Barrios García   +2 more
doaj   +1 more source