Results 1 to 10 of about 469 (131)

Population pharmacokinetics of a single bolus of ciprofol in Chinese pediatric patients [PDF]

BMC Anesthesiology
Background Ciprofol is a recently developed sedative similar to propofol, but there is a lack of bolus pharmacokinetic data for ciprofol in children.
Sicong Wang, Yan Li, Zhiyan Hu, Longzhi Du, Ying Wang, Xiaoya Jiang, Lujin Li, Wangning Shangguan   +7 more
doaj   +3 more sources

Drug–drug interaction study of ciprofol and sodium divalproex: Pharmacokinetics, pharmacodynamics, and safety in healthy Chinese subjects

Clinical and Translational Science, 2023
Ciprofol (also known as HSK3486) is a promising intravenous anesthetic candidate derived from propofol and independently developed by Haisco Pharmaceutical Group Co., Ltd. (Chengdu, China). Compared with propofol, ciprofol has the potential to reduce the
Dandan Yang, Wei Zhang, Zourong Ruan, Bo Jiang, Siqi Huang, Jiaying Wang, Pengfei Zhao, Mengyue Hu, Min Yan, Honggang Lou   +9 more
doaj   +2 more sources

Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?

BioMed Research International, Volume 2023, Issue 1, 2023., 2023
Ciprofol is a novel compound that was independently developed in China. According to the Chinese product instructions approved by the China National Medical Products Administration and the information of official website, indications for ciprofol include sedation and anesthesia during the surgical/procedure of nontracheal intubation, induction and ...
Ming Lu, Jian Liu, Xikun Wu, Zhiqing Zhang, Joho Tokumine   +4 more
wiley   +4 more sources

Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis

Frontiers in Pharmacology, 2022
Background and Purpose: Ciprofol (HSK3486), a novel 2,6-disubstituted phenol derivative, is a new intravenous anesthetic compound with a similar chemical structure to propofol.
Yunzhao Yang, Zhongyuan Xia, Cheng Xu, Chunchun Zhai, Xi Yu, Siqi Li   +5 more
doaj   +3 more sources

Ciprofol injection in patients receiving non-invasive positive pressure ventilation: a retrospective study [PDF]

Frontiers in Pharmacology
ObjectThis study aims to compare the efficacy and safety of ciprofol versus propofol in sedation for patients undergoing non-invasive positive pressure ventilation (NPPV), with a focus on evaluating sedative efficiency and systematically comparing the ...
DaLong Zhang, Lan Xiao, Xue Lv, ChenXi Ma, XiaoHan Zhang, XingGuo Niu   +5 more
doaj   +2 more sources

Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial

Pharmacology Research & Perspectives, 2023
Ciprofol is a newly developed intravenous anesthetic agent with improved pharmacokinetic properties. Compared to propofol, ciprofol exhibits stronger binding to the GABAA receptor and elicits a greater enhancement of GABAA receptor‐mediated neuronal ...
Gongchen Duan, Haiyan Lan, Weifeng Shan, Yini Wu, Qiaomin Xu, Xiaoli Dong, Peiyi Mei, Minji You, Linfei Jin, Jimin Wu   +9 more
doaj   +2 more sources

Incidence of injection pain between ciprofol and propofol after induction of general anesthesia: a systematic review and meta-analysis of randomized controlled trials [PDF]

Frontiers in Medicine
BackgroundPropofol and ciprofol are commonly used agents for inducing general anesthesia. Although propofol is preferred for its potent sedative effects and quick recovery, it is associated with a higher incidence of injection-related pain.
Jinfang Zeng, Guowei Zhu, Jinjin Jian, Minmin Zhu   +3 more
doaj   +2 more sources

Efficacy and Safety of Ciprofol Alone versus Ciprofol with Fentanyl for Upper Gastrointestinal Endoscopy: A Randomized, Double-Blind, Controlled Trial

Drug Design, Development and Therapy
Lu Liu,1 Feng Li,1 Yanxia Wei,2 Li Luo,1 Li Shen,1 Jie Li,1 Ninglin Sun,1 Bin Qian,1 Dawei Sun3 1Department of Anesthesiology, The First People’s Hospital of Yancheng, Yancheng, Jiangsu, People’s Republic of China; 2Department of Cardiology, The Second ...
Liu L, Li F, Wei Y, Luo L, Shen L, Li J, Sun N, Qian B, Sun D   +8 more
doaj   +2 more sources

The effects of CYP2B6 inactivators on the metabolism of ciprofol.

PLoS ONE
Ciprofol is a novel short-acting intravenous anaesthetic developed in China that is mainly metabolized by cytochrome P450 2B6 (CYP2B6) and uridine diphosphate glucuronosyltransferase 1A9 (UGT1A9).
Ming Lu, Xiaorui Zhang, Wenli Li, Xiangchen Li, Shan Li, Xiaoyu Yin, Zhiqing Zhang   +6 more
doaj   +3 more sources

Ciprofol versus propofol for sedation in colonoscopy: a systematic review and meta-analysis of randomized controlled trials [PDF]

Brazilian Journal of Anesthesiology
Background: Ciprofol has emerged as a potential alternative sedative with improved safety and efficacy. However, comparative data for colonoscopy sedation remain limited.
Saul Dominici, Italo C. Martins, Breno Dias L. Ribeiro, Victor Arthur Ohannesian, Brunno Braga Sauaia, Abdias Rocha Santos, Caio Márcio Barros de Oliveira, Plínio da Cunha Leal   +7 more
doaj   +2 more sources