Results 11 to 20 of about 469 (131)

Comparative study of ciprofol vs. propofol in carotid endarterectomy: focusing on mean arterial pressure, vasoactive drug use, and postoperative complications [PDF]

Frontiers in Medicine
AimThe aim of this study was to compare the effects of ciprofol and propofol on mean arterial pressure (MAP) management, vasoactive drug usage, and postoperative complications after carotid endarterectomy.MethodsA total of 103 patients were included in ...
Xinxin Zheng, Shiyun Deng, Lu Tian, Yanqing Zhang, Lin Bai   +4 more
doaj   +2 more sources

Ciprofol in Children Undergoing Adenoidectomy and Adenotonsillectomy: A Retrospective Cohort Study

Drug Design, Development and Therapy
Chao Zeng,1,* Lu Li,1,* Mengrui Wang,2,* Jun Xiong,1 Wenjuan Pang,1 Haiyan Yu,1 Jiadi He,1 Xuguang Wang,1 Yingying Chen,1 Yanyan Sun1 1Department of Anesthesiology, Shenzhen University General Hospital, Shenzhen University, Shenzhen ...
Zeng C, Li L, Wang M, Xiong J, Pang W, Yu H, He J, Wang X, Chen Y, Sun Y   +9 more
doaj   +3 more sources

A chronopharmacological comparison of ciprofol and propofol: focus on sedation and side effects

Frontiers in Molecular Neuroscience
Propofol is a commonly used intravenous anesthetic in clinical practice, while ciprofol, a propofol derivative, also targets GABAA receptors with enhanced anesthetic potency.
Xuehan Li, Xinqing Yang, Chen Chen, Ziqing Yu, Houping Wang, Ruixue Liu, Jianrong He, Bin Shu, Guangyou Duan, Erquan Zhang, Dapeng Ju, He Huang   +11 more
doaj   +3 more sources

Ciprofol suppresses glycolysis and EMT in colorectal cancer cells by activating APC to modulate the Wnt/β-catenin signaling pathway [PDF]

Scientific Reports
Ciprofol, an innovative anesthetic derived from propofol, has not yet been studied in detail regarding its effects in colorectal cancer (CRC). This study mainly explored the effects of Ciprofol on the epithelial-mesenchymal transition (EMT) process ...
Han Wu, Jiening Gao, Yong Wang, Yao Zhang, Li Jia, Weijing Li   +5 more
doaj   +2 more sources

A Common Neuronal Ensemble in the Lateral Habenula Regulates Ciprofol Anesthesia in Mice

Pharmaceuticals
General anesthetics were first used over 170 years ago; however, the mechanisms of how general anesthetics induce loss of consciousness (LOC) remain unclear.
Kang Zhou, Lin-Chen Zhang, He Zhu, Bei Wen, Jia-Li Tang, Ping-Chuan Yuan, A-Fang Zhu, Yu-Guang Huang   +7 more
doaj   +3 more sources

Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients

BMC Anesthesiology
Background Ciprofol, a novel intravenous anesthetic, which has primarily been used for the induction and maintenance of general anesthesia in adults, is characterized by rapid onset, short duration of action, and quick and smooth recovery.
Xiaowen Guo, Yang Qiao, Sijie Yin, Fengqin Luo, Lingmei Yi, Jiajia Chen, Man Lu   +6 more
doaj   +3 more sources

Optimal dosing of ciprofol for gastrointestinal endoscopy: a systematic review and network meta-analysis [PDF]

BMC Gastroenterology
Background The use of ciprofol for endoscopic sedation is relatively recent; however, no definitive conclusions have been drawn regarding its optimal dose. This study evaluated the optimal ciprofol dose for sedated endoscopy using a network meta-analysis.
Yating Yang, Danyang Pan, Guanzhu Li, Jinfeng Li, Jie Li   +4 more
doaj   +2 more sources

Association between preoperative anxiety and ciprofol requirements in women undergoing surgical abortion: a prospective observational study [PDF]

Frontiers in Medicine
ObjectiveTo investigate the association between preoperative anxiety level and ciprofol consumption in patients undergoing surgical abortion.MethodsA total of 144 patients scheduled for surgical abortion were enrolled and completed both the State–Trait ...
Baozhu Cha, Zhonghao Shao, Junchao Lv, Jiafei Cao, Qianwen Qin   +4 more
doaj   +2 more sources

Comparison of Ciprofol-Based and Propofol-Based Total Intravenous Anesthesia on Postoperative Recovery Quality in Patients Undergoing Hysteroscopic Surgery: A Randomized Non-Inferiority Trial [PDF]

Drug Design, Development and Therapy
Huan Yang, Yan Yang, Yihao Huang, Tao Liu, Yiheng Wang Department of Anesthesiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People’s Republic of ChinaCorrespondence: Yiheng Wang ...
Yang H, Yang Y, Huang Y, Liu T, Wang Y
doaj   +2 more sources

A bibliometric analysis of the published studies in ciprofol research. [PDF]

Medicine (Baltimore)
Objective: Ciprofol (HSK-3486), a novel intravenous anesthetic with structural similarities to propofol, has shown promising pharmacokinetic (PK) and pharmacodynamic (PD) profiles; however, clinical data regarding its efficacy and safety remain limited.
Wu W, Sun Y, Li Z, Yao Y, Evidence in Cardiovascular Anesthesia (EICA) Group.   +4 more
europepmc   +2 more sources