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Circadian rhythms are a ubiquitous adaptation of eukaryotic organisms to the most reliable and predictable of environmental changes, the daily cycles of light and temperature. Prominent daily rhythms in behavior, physiology, hormone levels and biochemistry (including gene expression) are not merely responses to these environmental cycles, however, but ...
Aronson, B. D. +20 more
openaire +5 more sources
Metabolic Effects of Bariatric Surgery in Mouse Models of Circadian Disruption [PDF]
Background/Objectives: Mounting evidence supports a link between circadian disruption and metabolic disease. Humans with circadian disruption (for example, night-shift workers) have an increased risk of obesity and cardiometabolic diseases compared with ...
Arble, Deanna M. +4 more
core +3 more sources
Circadian clocks and breast cancer [PDF]
Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V +3 more
core +2 more sources
Abstract Daily rhythms of light/darkness, activity/rest and feeding/fasting are important in human physiology and their disruption (for example by frequent changes between day and night shifts) increases the risk of disease. Many of the diseases found to be associated with such disrupted circadian lifestyles, including cancer ...
Jensen Lasse Dahl +2 more
openaire +3 more sources
Objective To determine whether long weekly work hours and shifts of extended duration (≥24 hours) are associated with adverse patient and physician safety outcomes in more senior resident physicians (postgraduate year 2 and above; PGY2+).Design ...
Christopher P Landrigan +5 more
doaj +1 more source
FLOWERING LOCUS C -dependent and -independent regulation of the circadian clock by the autonomous and vernalization pathways [PDF]
Background The circadian system drives pervasive biological rhythms in plants. Circadian clocks integrate endogenous timing information with environmental signals, in order to match rhythmic outputs to the local day/night cycle.
Amasino, Richard M. +5 more
core +4 more sources
Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao +8 more
core +1 more source
Environmental Circadian Disruption Elevates the IL-6 Response to Lipopolysaccharide in Blood [PDF]
The immune system is regulated by circadian clocks within the brain and immune cells. Environmental circadian disruption (ECD), consisting of a 6-h phase advance of the light:dark cycle once a week for 4 weeks, elevates the inflammatory response to ...
Adams, Kandis L. +3 more
core +2 more sources
It has been elucidated that the responses to light by the human eye influence not only color and brightness recognition but also physiological aspects such as hormones. Melatonin, which affects human circadian rhythms, is sensitive to the blue wavelength
Changwook Kim +3 more
doaj +1 more source
Background Melatonin is a hormone secreted by the pineal gland in a circadian rhythmic manner with peak synthesis at night. Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.
Cynthia Tchio +3 more
doaj +1 more source

