Results 41 to 50 of about 515,053 (332)

Voluntary exercise can strengthen the circadian system in aged mice [PDF]

, 2013
Consistent daily rhythms are important to healthy aging according to studies linking disrupted circadian rhythms with negative health impacts. We studied the effects of age and exercise on baseline circadian rhythms and on the circadian system's ability ...
A Davidson, A Power, A Watanabe, AA Kondratova, AC King, AJ Davidson, AJ Davidson, B Rusak, C Castillo, CJ Guenthner, DE Kolker, DF Swaab, DJ Buysse, DJ Dijk, DJ Foley, DJ Foley, E Satinoff, E. Zimmerman, EK Baehr, F Aujard, G. S. Lall, GJ Tranah, GS Passos, H Albus, H Li, H. Queenan, HT vanderLeest, I. Song, IN Karatsoreos, J Schaap, K Cho, KJ Reid, M Asai, M Harrington, M Münch, M Nagano, M Palomba, M. E. Harrington, MA Grandner, MJ Duncan, MJ Duncan, MU Gillette, MW Greene, MW Marlatt, N Mrosovsky, O Castanon-Cervantes, P. C. Molyneux, PC Yannielli, RD Nebes, S Ancoli-Israel, S Benloucif, S Farajnia, S Kiessling, S Yamazaki, S Yamazaki, S Yamazaki, S. M. Biello, SH Yoo, SJ Aton, SM Biello, T Deboer, T Yoshikawa, T. L. Leise, TA Bedrosian, TA Martino, TA Martino, TJ Nakamura, TL Leise, U Abraham, U Albrecht, VS Valentinuzzi, W Nakamura, Y Tahara, Y Zhang, Y Zhang   +74 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Analysis of Saccharomyces cerevisiae Circadian Rhythms in Continuous Culture [PDF]

, 2012
The circadian rhythm is a roughly 24-hour cycle in the physiological processes of organisms. There have been many studies on the circadian rhythms in other model organisms, but not in Saccharomyces cerevisiae. To study the rhythm in S.
Kohner, Melissa, Lyons, Carlton, Zager, Lauren   +2 more
core   +2 more sources

Rhythms of Locomotion Expressed by Limulus polyphemus, the American Horseshoe Crab: II. Relationship to Circadian Rhythms of Visual Sensitivity [PDF]

, 2008
In the laboratory, horseshoe crabs express a circadian rhythm of visual sensitivity as well as daily and circatidal rhythms of locomotion. The major goal of this investigation was to determine whether the circadian clock underlying changes in visual ...
Bedford, Lisa, Chabot, Christopher C., Watson, Winsor H., III   +2 more
core   +3 more sources

Genomics of circadian rhythms in health and disease

Genome Medicine, 2019
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral processes. The central circadian clock exerts control over myriad aspects of mammalian physiology, including the regulation of sleep, metabolism, and the immune ...
Filipa Rijo-Ferreira, J. Takahashi
semanticscholar   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Accurate timekeeping is controlled by a cycling activator in Arabidopsis. [PDF]

, 2013
Transcriptional feedback loops are key to circadian clock function in many organisms. Current models of the Arabidopsis circadian network consist of several coupled feedback loops composed almost exclusively of transcriptional repressors.
Devisetty, Upendra K, Harmer, Stacey L, Hsu, Polly Yingshan   +2 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]

, 2017
The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana, Leinweber, Brinja, Oster, Henrik, Tsang, Anthony H.   +3 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source