Emerging roles for microRNA in the regulation of Drosophila circadian clock
BMC Neuroscience, 2018 Background The circadian clock, which operates within an approximately 24-h period, is closely linked to the survival and fitness of almost all living organisms. The circadian clock is generated through a negative transcription-translation feedback loop.
Yongbo Xue, Yong Zhang
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Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. [PDF]
PLoS ONE, 2012 Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this
Hagoon Jang +5 more
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Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice
Current Issues in Molecular Biology, 2022 Lack of sleep time is a menace to modern people, and it leads to chronic diseases and mental illnesses. Circadian processes control sleep, but little is known about how sleep affects the circadian system.
Weitian Li +4 more
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Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
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Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions
Frontiers in Molecular Neuroscience, 2021 The zebrafish represents a powerful model for exploring how light regulates the circadian clock due to the direct light sensitivity of its peripheral clocks, a property that is retained even in organ cultures as well as zebrafish-derived cell lines ...
Gennaro Ruggiero +8 more
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Seeing inside the Body Using Wearable Sensing and Imaging Technologies
Advanced Healthcare Materials, EarlyView.This review explores wearable technologies for noninvasive internal health monitoring. It categorizes approaches into indirect sensing (e.g., bioelectrical and biochemical signals) and direct imaging (e.g., wearable ultrasound and EIT), highlighting multimodal integration and system‐level innovation toward personalized, continuous healthcare.
Sumin Kim +3 more
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Coordinated transcriptional regulation between a reactive oxygen species-responsive gene network and the circadian clock in Arabidopsis thaliana : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Plant Biology at Massey University, Plant Biology, New Zealand [PDF]
, 2012 Most organisms have evolved endogenous biological clocks as internal timekeepers to fine-tune physiological processes to the external environment. Energetic cycles such as photosynthesis and glycolytic cycles are physiological processes that have ...
Lai, Alvina Grace
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The Circadian Clock, Reward, and Memory [PDF]
Frontiers in Molecular Neuroscience, 2011 During our daily activities, we experience variations in our cognitive performance, which is often accompanied by cravings for small rewards, such as consuming coffee or chocolate. This indicates that the time of day, cognitive performance, and reward may be related to one another.
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The Circadian Clocks of Mice and Men [PDF]
Neuron, 2001 Major strides have been made toward understanding the molecular mechanism of rodent clocks. But how far do those steps carry us toward understanding circadian clock function in humans? Practical advances in human genetics, not the least of which is the availability of a virtually complete genome sequence, now allow animal research to be complemented by
Chang, Dennis C., Reppert, Steven M.
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Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans
Communications BiologyAnimals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate approximately 24-h biological rhythms. In C. elegans, the clock gene homologs constitute the “developmental clock”,
Shingo Hiroki, Hikari Yoshitane
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