Results 181 to 190 of about 113,418 (363)

A companion to the preclinical common data elements for rigor, reproducibility and transparency in basic and translational epilepsy research. A report of the TASK3‐WG1A: Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

open access: yesEpilepsia Open, EarlyView.
Abstract Rigorous and transparent procedures in preclinical epilepsy research studies are important to permit assessing the reproducibility of their findings and derisk their translation into the clinic. The General Pharmacology Working Group of the ILAE/AES Task Force (TASK3‐WG1A) developed common data elements (CDEs) addressing rigor and transparency
Brian D. Klein   +11 more
wiley   +1 more source

Rest‐activity rhythm phenotypes in adults with epilepsy and intellectual disability

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Rest‐activity rhythms (RARs) are perturbed in many forms of neuropsychiatric illness. In this study, we applied wrist actigraphy to describe RAR perturbations in intellectually disabled adults with epilepsy (“E + ID”), using a cross‐sectional case–control design.
Nandani Adhyapak   +3 more
wiley   +1 more source

Circadian biology: Clocks for the real world [PDF]

open access: bronze, 1999
Harriet G. McWatters   +2 more
openalex   +1 more source

Chronic thalamic recordings for idiopathic generalized epilepsy and Lennox–Gastaut syndrome: Ictal and interictal electrophysiological findings

open access: yesEpilepsia Open, EarlyView.
Abstract Objective To leverage RNS® System chronic thalamic EEG recordings to compare ictal and interictal thalamic electrophysiology in idiopathic generalized epilepsy (IGE) and Lennox–Gastaut Syndrome (LGS). Methods As part of ongoing clinical trials in IGE and LGS, intracranial EEG data were acquired from the centromedian nucleus (CM) bilaterally ...
Katie L. Bullinger   +3 more
wiley   +1 more source

THE MAMMALIAN CIRCADIAN CLOCK: GENE REGULATORY NETWORK AND THEIR COMPUTER ANALYSIS

open access: yesВавиловский журнал генетики и селекции, 2015
This paper presents the results of the reconstruction and analysis of gene regulatory network of the circadian clock in mammals. Application of graph theory methods makes it possible to analyze the structure of the gene network and identify the central ...
O. A. Podkolodnaya   +2 more
doaj  

Altered along‐the‐perivascular space index in functional (psychogenic non‐epileptic) seizures: A diffusion tensor imaging study of glymphatic system function

open access: yesEpilepsia Open, EarlyView.
Abstract Objective The glymphatic system is a critical brain waste‐clearance mechanism that facilitates the removal of metabolic byproducts and maintains neural homeostasis. Its dysfunction has been implicated in various neurological disorders; however, its role in functional (psychogenic nonepileptic) seizures (FS/PNES), a functional neurological ...
Mehrdad Roozbeh   +5 more
wiley   +1 more source

Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock [PDF]

open access: bronze, 1997
Chen Liu   +6 more
openalex   +1 more source

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